Patents by Inventor Ajit Varki

Ajit Varki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210062171
    Abstract: The present disclosure relates to novel sialidase enzymes having a preference for cleaving N-glycolylneuraminic acid (Neu5Gc) from glycoconjugates over cleaving N-acetylneuraminic acid (Neu5Ac). The present disclosure further provides the polypeptide of such novel sialidase and its catalytic pockets; the recombinant host cells expressing the same, as well as the enzymatic, pharmaceutical, and consumable compositions comprising such novel sialidases. Probiotic compositions comprising a bacterium that expresses the sialidase having a preference for Neu5Gc over Neu5Ac, and methods for removing Neu5Gc from consumable products are also provided. Also disclosed are methods for treating or preventing various diseases, disorders, and inflammatory conditions in a subject using the novel sialidases.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 4, 2021
    Applicant: The Regents of the University of California
    Inventors: Karsten Zengler, Ajit Varki, Frederico Da Silva, Sandra Diaz, Cameron Martino, Geoffrey Chang, Steven Rees, Livia Soares Zaramela
  • Publication number: 20200003779
    Abstract: The present application is in the field of sialic acid biochemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of Siglec-XII in a human biological sample for risk prediction, prognostication and diagnosis of disease. Also provided are devices configured to perform the methods disclosed herein.
    Type: Application
    Filed: August 27, 2019
    Publication date: January 2, 2020
    Inventors: Ajit Varki, Nissi Varki, Andrea Verhagen, Shoib Siddiqui
  • Publication number: 20190367548
    Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
    Type: Application
    Filed: May 21, 2019
    Publication date: December 5, 2019
    Inventors: Xi CHEN, An XIAO, Anoopjit KOONER, Abhishek SANTRA, Ajit VARKI, Hai YU, Lee-Ping WANG, Wanqing LI
  • Patent number: 9423401
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 23, 2016
    Assignees: The Regents of the University of California, Siamab Therapeutics, Inc.
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
  • Publication number: 20160106799
    Abstract: Embodiments of the present invention provide compositions and methods for the modulation of sialic acid levels. In some embodiments, compositions disclosed herein comprise nutraceuticals as functional agents.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 21, 2016
    Applicant: SIAMAB THERAPEUTICS, INC.
    Inventors: Mai Zhang, Darius Ghaderi, Jeffrey Behrens, Julie DeSander, Ajit Varki
  • Publication number: 20140315829
    Abstract: The invention relates to compositions and methods for increasing sialic acid uptake and/or incorporation into tissue following gastrointestinal ingestion of compositions that contain sialic acid.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Inventors: Ajit Varki, Kalyan Banda, Christopher J. Gregg
  • Patent number: 8828652
    Abstract: The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: September 9, 2014
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Publication number: 20140113979
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: The Regents of the University of California
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
  • Publication number: 20140057856
    Abstract: The invention relates to compositions and methods for increasing sialic acid uptake and/or incorporation into tissue following gastrointestinal ingestion of compositions that contain sialic acid.
    Type: Application
    Filed: August 22, 2013
    Publication date: February 27, 2014
    Applicant: The Regents of The Universtiy of California
    Inventors: Ajit Varki, Kalyan Banda, Christopher J. Gregg
  • Publication number: 20140044798
    Abstract: The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans.
    Type: Application
    Filed: August 13, 2013
    Publication date: February 13, 2014
    Applicant: The Regents of The University of California
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Patent number: 8541231
    Abstract: The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: September 24, 2013
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Publication number: 20130039991
    Abstract: The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans.
    Type: Application
    Filed: June 20, 2012
    Publication date: February 14, 2013
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Patent number: 8232448
    Abstract: This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: July 31, 2012
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Publication number: 20120142903
    Abstract: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies.
    Type: Application
    Filed: November 28, 2011
    Publication date: June 7, 2012
    Inventors: Ajit Varki, Pam Tangvoranuntakul, Nissi Varki, Elaine Muchmore
  • Publication number: 20120045816
    Abstract: Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human animal sources fed a diet supplemented with Neu5Gc competitor. Also provided herein are methods of treating a human subject with said compositions.
    Type: Application
    Filed: July 14, 2011
    Publication date: February 23, 2012
    Inventors: Darius Ghaderi, Ajit Varki
  • Patent number: 8084219
    Abstract: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: December 27, 2011
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Pam Tangvoranuntakul, Nissi Varki, Elaine Muchmore
  • Publication number: 20110195921
    Abstract: The disclosure provides a method of reducing or eliminating Neu5Gc in a cell culture or in a human subject. The method includes flooding the system with the human sialic acid i\7-acetylneuraminic acid (Neu5Ac) in glycosidically-bound or free form, or its precursor N-acetylmannosamine (ManNAc) in an amount sufficient to metabolically compete out the Neu5Gc, either as it enters the cells for the first time or when it recycles from break-down of preexisting cellular molecules. Additionally, Neu5Ac feeding results in reduction of Neu5Gc expression even in some animal cells capable of Neu5Gc production.
    Type: Application
    Filed: September 9, 2009
    Publication date: August 11, 2011
    Inventors: Ajit Varki, Sandra Diaz, Rachel Taylor
  • Publication number: 20110177614
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 21, 2011
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
  • Publication number: 20100293624
    Abstract: This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use.
    Type: Application
    Filed: June 8, 2006
    Publication date: November 18, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Publication number: 20100249383
    Abstract: The present invention provides methods and compositions involved in the inflammatory response, as well as various pathological processes. In particular, the present invention provides novel antibodies directed against novel glycans that are enriched on endothelial cell surfaces. In addition, the present invention provides methods and compositions involved in a previously unrecognized pathway of the inflammatory response and various pathological processes. In addition the present invention provides methods and compositions suitable to mediate the inflammatory response in various settings, as well as methods and compositions for the identification of other inflammatory response mediators.
    Type: Application
    Filed: July 13, 2009
    Publication date: September 30, 2010
    Inventors: Hudson Freeze, Geetha Srikrishna, Ajit Varki, Nissi Varki