Patents by Inventor Ajit Yoganathan
Ajit Yoganathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826503Abstract: Systems relate to a reusable console system that can be used with a plurality of different types of disposable cassettes. The cassettes may be structured for different therapies, different fluid volumes, among others, or a combination thereof. The disposable cassette may include a plurality of fluid circuits. Each circuit may include a pump chamber disposed along the path. The disposable cassette and the panel of a console may be configured to mate so that each of the one or more actuators of the console align with a pump chamber of the disposable cassette. The console may be configured to control a flow of the fluid in the path in the cassette when the disposable cassette is mated on the panel. Because the console can be mated with different cassettes, the system can efficiently and accurately deliver different medical fluid therapies and/or different patient populations (e.g., pediatric and adult).Type: GrantFiled: November 13, 2018Date of Patent: November 28, 2023Assignees: Children's Healthcare of Atlanta, Inc., Emory UniversityInventors: Matthew Paden, Sivakkumar Arjunon, Ajit Yoganathan, Brian Walsh
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Publication number: 20220233309Abstract: Systems and methods for replacing defective heart valves are disclosed. The systems and methods include providing a valve with a tubular frame, a plurality of valve leaflets, and an expanding member. The expanding member has a collapsed and an expanded configuration. In a collapsed configuration, the expanding member can be disposed within a catheter so that the valve can be percutaneously positioned at the defective heart valve. In the expanded configuration, the expanding member can open to exert a force on one or more native valve leaflets. By exerting the force on the native valve leaflets, the expanding member can press the native valve leaflets away from a surface of the tubular frame. Pushing the native valve leaflets from the tubular frame enables blood flow through the tubular frame and decreases the risk of thrombosis between the valve leaflets and the tubular frame.Type: ApplicationFiled: April 7, 2020Publication date: July 28, 2022Inventors: Ajit Yoganathan, Vahid Sadri, Phillip Michael Trusty
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Publication number: 20210346097Abstract: Methods for determining likelihood of thrombosis based on patient-specific anatomic, valve, and flow parameters are disclosed herein. Such methods are used to select a transcatheter aortic valve that decreases likelihood of thrombosis after TAVR procedures. The methods correlate a number of fluid flow and geometric parameters such as stasis volume, neo-sinus volume, kinematic viscosity, dynamic viscosity, heart rate, the circulation, ejection time, velocity of the main jet, wall shear stress, total kinetic energy in the neo sinus volume, width of the neo-sinus, height or depth of the neo-sinus, the angle between the velocity direction and the stent of the transcatheter valve, the distance from the tip of the leaflet perpendicular to the leaflet edge and intersecting the sinotubular junction, and the cross-sectional area of the neo-sinus taken from a longitudinal or axial perspective. Such parameters are used to derive empirical or semi-empirical mathematical models to determine the likelihood of thrombosis.Type: ApplicationFiled: July 22, 2021Publication date: November 11, 2021Applicants: Ohio State Innovation Foundation, Georgia Tech Research CorporationInventors: Lakshmi Prasad Dasi, Amirsepehr Azimian, Hoda Hatoum, Shelly Singh-Gryzbon, Vinod Thourani, Ajit Yoganathan
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Patent number: 11027103Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: March 13, 2018Date of Patent: June 8, 2021Assignees: Emory University, Georgia Tech Research CorporationInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Heman Jimenez
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Publication number: 20200297910Abstract: Systems relate to a reusable console system that can be used with a plurality of different types of disposable cassettes. The cassettes may be structured for different therapies, different fluid volumes, among others, or a combination thereof. The disposable cassette may include a plurality of fluid circuits. Each circuit may include a pump chamber disposed along the path. The disposable cassette and the panel of a console may be configured to mate so that each of the one or more actuators of the console align with a pump chamber of the disposable cassette. The console may be configured to control a flow of the fluid in the path in the cassette when the disposable cassette is mated on the panel. Because the console can be mated with different cassettes, the system can efficiently and accurately deliver different medical fluid therapies and/or different patient populations (e.g., pediatric and adult).Type: ApplicationFiled: November 13, 2018Publication date: September 24, 2020Inventors: Matthew PADEN, Sivakkumar ARJUNON, Ajit YOGANATHAN, Brian WALSH
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Patent number: 10674993Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a mitral valve. A flow quantification processor (34) in the ultrasound system produces a mathematical model of a flow velocity field proximal to a regurgitant orifice. The velocity field model produces values of velocity vectors directed toward the regurgitant orifice. These modeled values are modified for the effects of ultrasound physics and ultrasound system operation to produce expected velocity values. The expected velocity values are compared with actual Doppler velocities measured by the ultrasound system, and the differences accumulated to a mean square error which is used to adjust parameters of the model such as the orifice location and flow velocities. When this iterative processing converges with a desired comparison, parameters derived from the finally adjusted model are used to calculate the true orifice location, flow rate, and volume flow.Type: GrantFiled: December 16, 2011Date of Patent: June 9, 2020Assignees: KONINKLIJKE PHILIPS N.V., GEORGIA TECH RESEARCHInventors: Qifeng Wei, Karl Thiele, Ajit Yoganathan, Choon-Hwai Yap
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Patent number: 10231693Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a mitral valve, including the automatic indication of the location of a regurgitant orifice in an ultrasound image. A clinician images the regurgitant valve and indicates in the image the presumed location of the regurgitant orifice (130). A flow quantification processor is responsive to this initial location estimate by the clinician to calculate a refined estimation of the orifice location. The refined location is indicated on the ultrasound image by the imaging system, either by relocating an icon placed by the clinician, or displaying a second icon (132) on the image at the refined location.Type: GrantFiled: December 16, 2011Date of Patent: March 19, 2019Assignee: Koninklijke Philips N.V.Inventors: Qifeng Wei, Karl Erhard Thiele, Ajit Yoganathan, Choon-Hwai Yap
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Publication number: 20180200492Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: ApplicationFiled: March 13, 2018Publication date: July 19, 2018Inventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Heman Jimenez
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Patent number: 9950146Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: March 2, 2016Date of Patent: April 24, 2018Assignees: EMORY UNIVERISTY, GEORGIA TECH RESEARCH CORPORATIONInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Publication number: 20170173306Abstract: Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's vessels. The splittable needles are provided with a clamp, which has radially protruding handles and alignment and locking mechanisms. The splittable needles precisely split and separate into respective individual parts following pressing of clamp handles together.Type: ApplicationFiled: March 24, 2015Publication date: June 22, 2017Inventors: Gautam Kumar, Sivakkumar Arjunon, Yegor Podgorsky, Ajit Yoganathan
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Publication number: 20160317793Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: ApplicationFiled: March 2, 2016Publication date: November 3, 2016Inventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Patent number: 9308015Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: September 2, 2014Date of Patent: April 12, 2016Assignees: Emory University, Georgia Tech Research CorporationInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Publication number: 20160051800Abstract: The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue wall. The present invention further provides a system for implanting such a vascular conduit device in a tissue wall. More specifically, the present invention provides a system including a coring device for defining an aperture in a tissue wall (such as a ventricle and/or a blood vessel) and securely implanting a vascular conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the vascular conduit device.Type: ApplicationFiled: August 21, 2015Publication date: February 25, 2016Inventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Patent number: 9138228Abstract: The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue wall. The present invention further provides a system for implanting such a vascular conduit device in a tissue wall. More specifically, the present invention provides a system including a coring device for defining an aperture in a tissue wall (such as a ventricle and/or a blood vessel) and securely implanting a vascular conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the vascular conduit device.Type: GrantFiled: October 14, 2005Date of Patent: September 22, 2015Assignees: Emory University, Georgia Tech Research InstituteInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Publication number: 20140371518Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: ApplicationFiled: September 2, 2014Publication date: December 18, 2014Inventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Patent number: 8858489Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: March 18, 2013Date of Patent: October 14, 2014Assignees: Emory University, Georgia Tech Research CorporationInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Patent number: 8821135Abstract: The devices and systems are medical fluid treatment therapies. The device and systems are configured and capable of operating based on small volumes of fluids. The devices and systems include a pump configured for small volume of a fluid. The pump may include a first conduit configured for inflow of the fluid; a second conduit configured for outflow of the fluid; a fluid chamber configured to move the fluid through the pump; a diaphragm configured to force the fluid through the fluid chamber by indirectly exerting force on the fluid chamber; and a connector configured to removably attach the pump to a motor.Type: GrantFiled: August 25, 2011Date of Patent: September 2, 2014Assignees: Emory University, Georgia Tech Research CorporationInventors: Matthew L. Paden, Ajit Yoganathan, Lakshmi Prasad Dasi
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Publication number: 20130274606Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a mitral valve. A flow quantification processor (34) in the ultrasound system produces a mathematical model of a flow velocity field proximal to a regurgitant orifice. The velocity field model produces values of velocity vectors directed toward the regurgitant orifice. These modeled values are modified for the effects of ultrasound physics and ultrasound system operation to produce expected velocity values. The expected velocity values are compared with actual Doppler velocities measured by the ultrasound system, and the differences accumulated to a mean square error which is used to adjust parameters of the model such as the orifice location and flow velocities. When this iterative processing converges with a desired comparison, parameters derived from the finally adjusted model are used to calculate the true orifice location, flow rate, and volume flow.Type: ApplicationFiled: December 16, 2011Publication date: October 17, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Qifeng Wei, Karl Thiele, Ajit Yoganathan, Choon-Hwai Yap
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Publication number: 20130261457Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a mitral valve, including the automatic indication of the location of a regurgitant orifice in an ultrasound image. A clinician images the regurgitant valve and indicates in the image the presumed location of the regurgitant orifice (130). A flow quantification processor is responsive to this initial location estimate by the clinician to calculate a refined estimation of the orifice location. The refined location is indicated on the ultrasound image by the imaging system, either by relocating an icon placed by the clinician, or displaying a second icon (132) on the image at the refined location.Type: ApplicationFiled: December 16, 2011Publication date: October 3, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Qifeng Wei, Karl Erhard Thiele, Ajit Yoganathan, Choon-Hwai Yap
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Patent number: 8430836Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: October 11, 2010Date of Patent: April 30, 2013Assignees: Emory University, Georgia Tech Research CorporationInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez