Patents by Inventor Ake P. Elhammer

Ake P. Elhammer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aureobasidium derivatives and methods of synthesis
    Patent number: 11066447
    Abstract: In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various fungal infections.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: July 20, 2021
    Assignee: AueroGen Biosciences, Inc.
    Inventors: Peter Wuts, Ake P. Elhammer
  • AUREOBASIDIUM DERIVATIVES AND METHODS OF SYNTHESIS
    Publication number: 20190292225
    Abstract: In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various fungal infections.
    Type: Application
    Filed: August 8, 2017
    Publication date: September 26, 2019
    Inventors: Peter Wuts, Ake P. Elhammer
  • Aureobasidin derivatives and methods of synthesis
    Patent number: 8906848
    Abstract: In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable for industrial production and employ safer, simpler, and more efficient process conditions. Furthermore, the invention also provides novel compounds and intermediates useful for implementing the methods described herein and/or for the treatment of infection.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: December 9, 2014
    Assignee: AureoGen Biosciences, inc.
    Inventors: Peter Wuts, Ake P. Elhammer
  • AUREOBASIDIN DERIVATIVES AND METHODS OF SYNTHESIS
    Publication number: 20140024578
    Abstract: In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable for industrial production and employ safer, simpler, and more efficient process conditions. Furthermore, the invention also provides novel compounds and intermediates useful for implementing the methods described herein and/or for the treatment of infection.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 23, 2014
    Applicant: AureoGen Biosciences ,Inc.
    Inventors: Peter Wuts, Ake P. Elhammer
  • Aureobasin a synthetase
    Publication number: 20090325155
    Abstract: Disclosed are polynucleotides encoding polypeptides having Aureobasidin A synthetase activity and Aureobasidin A synthetase-like activity. The invention also provides methods for detecting AbA synthetase proteins and nucleic acids and AbA synthetase-like proteins and nucleic acids in cells, and method for producing AbA synthetase polypeptides.
    Type: Application
    Filed: August 25, 2006
    Publication date: December 31, 2009
    Inventors: Ake P. Elhammer, Jerry L. Slightom, Brian P. Metzger
  • Methods of treating infection
    Publication number: 20090124539
    Abstract: The present invention relates to methods of inhibiting the proliferation of bacteria for either ex vivo or in vivo use. The invention also relates to methods of treating a patient infected with an antibiotic resistant bacteria by administering a pharmaceutical composition comprising an Empedopeptin; methods of sanitizing surfaces and instruments; and methods of assaying bacteria for Empedopeptin resistance.
    Type: Application
    Filed: September 26, 2008
    Publication date: May 14, 2009
    Inventors: Ake P. Elhammer, Torsten Stachelhaus
  • High-efficiency assay for protein mannosyl transferases
    Publication number: 20030017520
    Abstract: The present invention provides novel procedures to assay the activity of protein mannosyl transferases ability to catalyze the transfer of mannose from the donor sugar lipid dolichyl phosphoryl mannose to the acceptor peptide and agents or compounds that inhibit the activity of protein mannosyl transferases.
    Type: Application
    Filed: May 13, 2002
    Publication date: January 23, 2003
    Inventors: Ake P. Elhammer, Ference J. Kezdy
  • Cloned DNA encoding a UDP-GalNAc: Polypeptide, N-acetylgalactosaminyltransferase
    Patent number: 6096512
    Abstract: The present invention relates to a method for the isolation and expression of a glycosyltransferase enzyme for use in the synthesis of oligosaccharide or polysaccharide structures on glycoproteins, glycolipids, or as free molecules. The gene coding for the enzyme N-acetylgalactosaminyltransferase and the polypeptide sequence of the acceptor peptide for the enzyme N-acetylgalactosaminyltransferase have been isolated and used for the control of glycosylation of a protein.
    Type: Grant
    Filed: November 11, 1997
    Date of Patent: August 1, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ake P. Elhammer, Fred L. Homa
  • Cloned DNA encoding a UDP-GalNAc: polypeptide N-acetylgalactosaminy-ltransferase
    Patent number: 5910570
    Abstract: The present invention relates to a method for the isolation and expression of a glycosyltransferase enzyme for use in the synthesis of oligosaccharide or polysaccharide structures on glycoproteins, glycolipids, or as free molecules. The gene coding for the enzyme N-acetylgalactosaminyltransferase and the polypeptide sequence of the acceptor peptide for the enzyme N-acetylgalactosaminyltransferase have been isolated and used for the control of glycosylation of a protein.
    Type: Grant
    Filed: November 11, 1997
    Date of Patent: June 8, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ake P. Elhammer, Fred L. Homa
  • Scintillation proximity assay for N-acetylgalactosaminyltransferase activity
    Patent number: 5861318
    Abstract: This invention comprises a scintillation proximity assay designed to assay for the presence of N-acetylgalactosaminyltransferase, also known as GalNAc-transferase. The assay is most conveniently carried out on 96-well microtiterplates. The assay is especially suitable for large volume screens for compounds affecting GalNAc-transferase activity.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: January 19, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventor: Ake P. Elhammer