Patents by Inventor Akemi SHONO

Akemi SHONO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic drug for Alport's syndrome
    Patent number: 11230709
    Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).
    Type: Grant
    Filed: December 25, 2017
    Date of Patent: January 25, 2022
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, DAIICHI SANKYO COMPANY LIMITED
    Inventors: Kazumoto Iijima, Kandai Nozu, Akemi Shono, Makoto Koizumi, Yoshiyuki Onishi, Kiyosumi Takaishi, Tomomi Adachi
  • THERAPEUTIC DRUG FOR ALPORT'S SYNDROME
    Publication number: 20200080080
    Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).
    Type: Application
    Filed: December 25, 2017
    Publication date: March 12, 2020
    Applicants: DAIICHI SANKYO COMPANY, LIMITED, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Kazumoto IIJIMA, Kandai NOZU, Akemi SHONO, Makoto KOIZUMI, Yoshiyuki ONISHI, Kiyosumi TAKAISHI, Tomomi ADACHI