Abstract: The present disclosure relates to a CD47-SIRP? blocking agent of formula (I) stereoisomers thereof, and pharmaceutically acceptable salts, solvates, amides and esters of the compound of formula (I) and stereoisomer thereof and Azacitidine for use in combination with Azacitidine in a method of treating or delaying progression of a disease or a disorder mediated by CD47-SIRP? pathway in a human subject suffering from said disease, such as hematological cancer.

Abstract: A computer implemented method is disclosed herein for monitoring and determining a quality level of incoming raw material from one or more sources. The method includes (1) receiving visual data associated with the incoming raw material; (2) determining an indication of quality level associated with the incoming raw material; and (3) transmitting, to at least one of a graphical user interface (GUI) and a computer log, the indication of quality level and at least one timestamp associated with the visual data. The visual data may include a plurality of images received from one or more cameras configured for monitoring the incoming raw material. A related system is also disclosed herein.

Abstract: The present invention provides a combination of a substituted heterocyclyl derivative of formula (I) or a pharmaceutically acceptable salt thereof which is a CDK7 inhibitor along with an anti-cancer agent or a prodrug thereof, and a method of treating and/or preventing cancer in a subject, comprising administering to the subject a compound of formula (I) conjointly with the anti-cancer agent.

Abstract: The present invention provides a combination of a substituted heterocyclyl derivative of formula (I) or a pharmaceutically acceptable salt thereof which is a CDK7 inhibitor along with an anti-microtubule agent or prodrug thereof, and a method of treating or preventing cancer in a subject, comprising administering to the subject a compound of formula (I) conjointly with the anti-microtubule agent.

Abstract: A computer implemented method is disclosed herein for monitoring and determining a quality level of incoming raw material from one or more sources. The method includes (1) receiving visual data associated with the incoming raw material; (2) determining an indication of quality level associated with the incoming raw material; and (3) transmitting, to at least one of a graphical user interface (GUI) and a computer log, the indication of quality level and at least one timestamp associated with the visual data. The visual data may include a plurality of images received from one or more cameras configured for monitoring the incoming raw material. A related system is also disclosed herein.

Abstract: Examples of the present disclosure may include methods, systems, and computer readable media with executable instructions. An example method for providing a patient information interface can include accessing patient health record (PHR) information for a particular patient, and referencing medical care guideline information. A medical process associated with the particular patient is determined based on the PHR information and medical care guideline information, and context information associated with the particular patient and/or a healthcare system is received in a medical process-aware manner to a context model implemented on a computing system, including clinical, logistical and operational information. Context aware information is presented, via an output device of the computing system based on the determined medical process and context information.