Patents by Inventor Akifumi Hagi
Akifumi Hagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11229615Abstract: An object of the present invention is to provide a composition that can be used as a novel anti-inflammatory agent. An inflammation such as stomatitis, oral mucositis, gingivitis, or pneumonia can be ameliorated and/or prevented by using a composition comprising olanexidine or a pharmacologically acceptable salt thereof. The composition of the present invention preferably further comprises a poloxamer which is a block copolymer consisting of a chain of polyoxypropylene (POP) and two chains of polyoxyethylene (POE) flanking the POP.Type: GrantFiled: April 10, 2018Date of Patent: January 25, 2022Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Takuya Nii, Akifumi Hagi, Yoshie Tsubotani
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Publication number: 20210121417Abstract: An object of the present invention is to provide a composition that can be used as a novel anti-inflammatory agent. An inflammation such as stomatitis, oral mucositis, gingivitis, or pneumonia can be ameliorated and/or prevented by using a composition comprising olanexidine or a pharmacologically acceptable salt thereof. The composition of the present invention preferably further comprises a poloxamer which is a block copolymer consisting of a chain of polyoxypropylene (POP) and two chains of polyoxyethylene (POE) flanking the POP.Type: ApplicationFiled: April 10, 2018Publication date: April 29, 2021Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Takuya NII, Akifumi HAGI, Yoshie TSUBOTANI
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Patent number: 10888535Abstract: It is to provide a disinfectant liquid which enables easy identification of the application sites in preoperative skin disinfection and the like, where the liquid is obtained by coloring an aqueous solution of olanexidine gluconate which is a colorless and transparent liquid. A disinfectant liquid comprises olanexidine gluconate, a coloring agent such as Sunset Yellow FCF, an alkyl dimethylamine oxide such as lauryl dimethylamine oxide, and optionally one or more surfactants other than alkyl dimethylamine oxide such as polyoxyethylene alkyl ether including lauromacrogol and polyoxyethylene polyoxypropylene alkyl ether including polyoxyethylene(20) polyoxypropylene(4) cetyl ether. The disinfectant liquid enables easy identification of the application sites in preoperative skin disinfection and the like.Type: GrantFiled: November 30, 2016Date of Patent: January 12, 2021Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Mari Shiozaki, Ryohei Tsubakiyama, Motoya Kikuchi, Kaoru Imai, Akifumi Hagi
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Publication number: 20190000783Abstract: It is to provide a disinfectant liquid which enables easy identification of the application sites in preoperative skin disinfection and the like, where the liquid is obtained by coloring an aqueous solution of olanexidine gluconate which is a colorless and transparent liquid. A disinfectant liquid comprises olanexidine gluconate, a coloring agent such as Sunset Yellow FCF, an alkyl dimethylamine oxide such as lauryl dimethylamine oxide, and optionally one or more surfactants other than alkyl dimethylamine oxide such as polyoxyethylene alkyl ether including lauromacrogol and polyoxyethylene polyoxypropylene alkyl ether including polyoxyethylene(20) polyoxypropylene(4) cetyl ether. The disinfectant liquid enables easy identification of the application sites in preoperative skin disinfection and the like.Type: ApplicationFiled: November 30, 2016Publication date: January 3, 2019Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Mari SHIOZAKI, Ryohei TSUBAKIYAMA, Motoya KIKUCHI, Kaoru IMAI, Akifumi HAGI
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Patent number: 8334248Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: GrantFiled: September 10, 2010Date of Patent: December 18, 2012Assignees: Otsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc.Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Publication number: 20100331423Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: ApplicationFiled: September 10, 2010Publication date: December 30, 2010Applicants: Otsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc.Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Patent number: 7829518Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: GrantFiled: May 25, 2004Date of Patent: November 9, 2010Assignees: Otsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc,Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Patent number: 7825080Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: GrantFiled: October 27, 2006Date of Patent: November 2, 2010Assignees: Otsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc.Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Patent number: 7259155Abstract: The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1–3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.Type: GrantFiled: May 5, 2004Date of Patent: August 21, 2007Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Yasuhiro Sakai, Kazuyoshi Miyata, Takahiro Tomoyasu, Akiyoshi Kuroda, Yasuhide Inoue, Akifumi Hagi, Shinya Miki, Norihiro Yoshinaga, Masako Doi, Yoshihiko Tsuda, Seiichirou Kanou
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Publication number: 20070041866Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: ApplicationFiled: October 27, 2006Publication date: February 22, 2007Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Publication number: 20060189500Abstract: The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.Type: ApplicationFiled: May 25, 2004Publication date: August 24, 2006Inventors: Kazuyoshi Miyata, Yasuhide Inoue, Akifumi Hagi, Motoya Kikuchi, Hitoshi Ohno, Kinji Hashimoto, Kinue Ohguro, Tetsuya Sato, Hidetsugu Tsubouchi, Hiroshi Ishikawa, Takashi Okamura, Koushi Iwata
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Publication number: 20050256087Abstract: The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1-3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.Type: ApplicationFiled: May 5, 2004Publication date: November 17, 2005Inventors: Yasuhiro Sakai, Kazuyoshi Miyata, Takahiro Tomoyasu, Akiyoshi Kuroda, Yasuhide Inoue, Akifumi Hagi, Shinya Miki, Norihiro Yoshinaga, Masako Doi, Yoshihiko Tsuda, Seiichirou Kanou