Patents by Inventor Akifumi Ootani

Akifumi Ootani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ex vivo culture, proliferation and expansion of intestinal epithelium
    Patent number: 10704026
    Abstract: Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: July 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Calvin Jay Kuo, Akifumi Ootani
  • Ex vivo culture, proliferation and expansion of intestinal epithelium
    Patent number: 9464275
    Abstract: Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: October 11, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Calvin Jay Kuo, Akifumi Ootani
  • EX VIVO CULTURE, PROLIFERATION AND EXPANSION OF INTESTINAL EPITHELIUM
    Publication number: 20150344849
    Abstract: Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.
    Type: Application
    Filed: August 10, 2015
    Publication date: December 3, 2015
    Inventors: Calvin Jay Kuo, Akifumi Ootani
  • Ex Vivo Culture, Proliferation and Expansion of Intestinal Epithelium
    Publication number: 20100047853
    Abstract: Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Inventors: Calvin Jay Kuo, Akifumi Ootani
  • Suppression of inflammation associated with transplantation using an epsilon PKC inhibitor
    Publication number: 20090124553
    Abstract: The described compositions and methods relate to the suppression of inflammatory responses following allograft transplantation by administering an inhibitor of epsilon protein kinases c (?PKC) following transplantation.
    Type: Application
    Filed: May 2, 2008
    Publication date: May 14, 2009
    Inventors: Daria D. Mochly-Rosen, Tomoyoshi Koyanagi, Koichi Inagaki, Akifumi Ootani