Patents by Inventor Akiharu Kubo

Akiharu Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allergic disease model animals
    Patent number: 8350118
    Abstract: The object of the present invention is to provide a mouse model for allergic diseases such as atopic dermatitis, and a dermatitis mouse model with impaired skin-barrier function. The present inventors found out that a mouse that has been caused to completely lose the function of expressing profilaggrin protein and filaggrin protein by entirely or partially disrupting the endogenous gene encoding filaggrin by a genetic mutation such as deletion or replacement, can be used as a mouse model for allergic diseases or atopic dermatitis wherein the skin-barrier function has been impaired.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: January 8, 2013
    Assignee: Keio University
    Inventors: Masayuki Amagai, Akiharu Kubo, Keisuke Nagao
  • ALLERGIC DISEASE MODEL ANIMALS
    Publication number: 20110088103
    Abstract: The object of the present invention is to provide a mouse model for allergic diseases such as atopic dermatitis, and a dermatitis mouse model with impaired skin-barrier function. The present inventors found out that a mouse that has been caused to completely lose the function of expressing profilaggrin protein and filaggrin protein by entirely or partially disrupting the endogenous gene encoding filaggrin by a genetic mutation such as deletion or replacement, can be used as a mouse model for allergic diseases or atopic dermatitis wherein the skin-barrier function has been impaired.
    Type: Application
    Filed: May 15, 2009
    Publication date: April 14, 2011
    Inventors: Masayuki Amagai, Akiharu Kubo, Keisuke Nagao