Abstract: A highly safe and highly heat-resistant L-rhamnose isomerase usable in the food industry and the production thereof are disclosed. The L-rhamnose isomerase is derived from a microorganism belonging to the genus Enterobacter, has a subunit molecular mass of 47 kDa as measured by SDS-PAGE, and has the following substrate specificities (A) isomerase activity that recognizes and reacts with a CHO group at C1 and an OH group at C2 of an aldose to convert the CHO group at C1 into an OH group and the OH group at C2 into a CO group, or recognizes and reacts with an OH group at C1 and a CO group at C2 of a ketose to convert the OH group at C1 into a CHO group and the CO group at C2 into an OH group; and (B) reactivity with L-rhamnose, L-lyxose, L-mannose, D-allose, D-ribose, and L-talose.

Abstract: The present invention provides a composition for treating or preventing renal cell cancer, the composition comprising, as an active ingredient, D-allose and/or a derivative thereof and/or a mixture thereof, and being characterized by being administered through the intestinal tract (for example, oral administration). Moreover, the present invention provides a method for treating or preventing renal cell cancer in a subject, the method comprising administering a composition, which is for treating or preventing renal cell cancer and contains D-allose as an active ingredient, to a subject in need thereof through the intestinal tract (for example, oral administration).

Abstract: Provided is a pharmaceutical composition that is for prevention or treatment of urinary tract organ cancer, causes no adverse side effects, can be continuously used for a long time, and is administered to the urinary tract organ by injection into the urinary tract organ cavity. A solution for injection into the urinary tract organ cavity contains D-allose. The inside of the urinary tract organ cavity is the inside of the upper urinary tract and the inside of the bladder. The solution is for injection therapy into the urinary tract organ cavity. The solution uses enhancement of sugar uptake into cancer cells of the urinary tract organ (for example, RT112, 253J, J82) by D-allose. The solution contains D-allose together with a pharmaceutically acceptable diluent or carrier. The solution is a pharmaceutical composition for prevention or treatment of urinary tract organ cancer.

Abstract: Provided is an improved glucose-containing peritoneal dialysate, an ophthalmic composition, or an infusion that can suppress a blood glucose level increase even when used in a long-term treatment and can also suppress an infectious disease, by only addition. A D-glucose-containing osmotic pressure regulator includes D-allose and/or D-allulose as an additive for suppressing a blood glucose level increase by continuous absorption of glucose into the body and for suppressing an infectious disease. The osmotic pressure regulator is used as a mixture with a peritoneal dialysate, an ophthalmic composition, or an infusion. A peritoneal dialysis method for suppressing a blood glucose level increase by continuous absorption of glucose into the body through peritoneal dialysis and for suppressing an infectious disease uses a dialysate containing D-allose and/or D-allulose in an effective amount.

Abstract: To provide a composition for the treatment of renal cell carcinoma and a composition or a method for enhancing the uptake of a drug into renal cell carcinoma cells. Provided are a D-allose-containing composition for the treatment of renal cell carcinoma, and a D-allose-containing composition or method for enhancing the uptake of a drug into renal cell carcinoma cells. The composition is a pharmaceutical composition to be administered in an effective amount to patients requiring the treatment of renal cell carcinoma in humans or animals other than humans.

Abstract: To provide a ketose 3-epimerase that can be used in the food industry and is highly safe, highly active, and heat resistant, a microorganism that produces this enzyme, and a method of producing a ketose. The present invention provides a ketose 3-epimerase that can be obtained from a microorganism belonging to the genus Arthrobacter, has a molecular mass of about 36 kDa as measured by SDS-PAGE, and has the following substrate specificities (A) and (B): (A) having an activity of epimerizing position 3 of a D- or L-ketose and preparing a D- or L-ketose corresponding thereto, and (B) having the highest epimerization activity on position 3 of D-allulose, among D- or L-ketohexoses.

Abstract: To provide a brown and beige adipocyte activating agent and a brown and beige adipocyte activating food, each containing D-allulose as an active ingredient. Provided are a brown and beige adipocyte activating agent containing D-allulose as an active ingredient; a brown and beige adipocyte activating agent containing at least D-allulose and having a UCP-1 expression promoting action; a brown and beige adipocyte activating agent which enhances UCP-1 expression and thereby activates brown and beige adipocytes; an energy consumption promoting agent containing D-allulose as an active ingredient; an energy consumption promoting agent which activates brown and beige adipocytes and thereby promotes energy consumption; a UCP-1 expression enhancing agent containing D-allulose as an active ingredient; and a composition or food composition containing these agents.

Abstract: An object of the present invention is to provide a rare sugar-containing composition having improved properties as a sweetener while maintaining the excellent functionality of D-psicose. The invention relates to a method of producing a rare-sugar containing composition with D-fructose as a raw material. An intended product having a novel composition of D-glucose, D-fructose, and D-psicose is obtained by preparing a mixture of D-fructose and D-psicose by using ketose 3-epimerase in the first stage and converting D-fructose into D-glucose by using D-xylose isomerase inert to D-psicose in the second stage. The first-stage product is a mixture of D-fructose and rare sugar D-psicose. The resulting mixture is a sweetener having a taste quality equal to that of sugar.