Patents by Inventor Akihiko Kishimoto

Akihiko Kishimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8975066
    Abstract: Accurate and sensitive sequencing in pyrosequencing is achieved by allowing complementary strand synthesis reaction to proceed homogeneously and completely in a short time while performing luminescence reaction for a sufficiently long time. DNA as a sequencing target is immobilized on the surface of a solid support. Nucleic acid substrates are injected from a dispenser to the support site where complementary strand synthesis is in turn performed rapidly and completely in a short time under a small reaction volume. Next, the support together with the product thereon is moved into a luminescence reaction solution where luminescence reaction is in turn performed. Thus, a DNA complementary strand synthesis reaction site and a luminescence reaction site are completely separated. The support surface is also washed by dipping the support in the luminescence reaction solution that contains a luminescence reagent and an enzyme that degrades redundant nucleic acid substrates.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: March 10, 2015
    Assignee: Hitachi, Ltd.
    Inventors: Hideki Kambara, Akihiko Kishimoto
  • Publication number: 20090253194
    Abstract: Accurate and sensitive sequencing in pyrosequencing is achieved by allowing complementary strand synthesis reaction to proceed homogeneously and completely in a short time while performing luminescence reaction for a sufficiently long time. DNA as a sequencing target is immobilized on the surface of a solid supporter. Nucleic acid substrates are injected from a dispenser to the supporter site where complementary strand synthesis is in turn performed rapidly and completely in a short time under a small reaction volume. Next, the supporter together with the product thereon is moved into a luminescence reaction solution where luminescence reaction is in turn performed. Thus, a DNA complementary strand synthesis reaction site and a luminescence reaction site are completely separated. The-supporter surface is also washed by dipping the supporter in the luminescence reaction solution that contains a luminescence reagent and an enzyme that degrades redundant nucleic acid substrates.
    Type: Application
    Filed: April 7, 2009
    Publication date: October 8, 2009
    Applicant: HITACHI, LTD.
    Inventors: Hideki KAMBARA, Akihiko KISHIMOTO
  • Publication number: 20070054283
    Abstract: The present invention provides an inexpensive DNA sequencing method with high-sensitivity. The method of the present invention comprising the steps of, adding an given amount of dATP for step by step complementary strand synthesis and subtracting the background luminescence intensity caused by dATP from the measured luminescence intensity to obtain the luminescence intensity involved in complementary strand synthesis.
    Type: Application
    Filed: February 17, 2006
    Publication date: March 8, 2007
    Inventors: Akihiko Kishimoto, Hideki Kambara, Tomoharu Kajiyama, Guohua Zhou
  • Patent number: 5886097
    Abstract: Thermoplastic resin compositions consisting of 1 to 40 wt % a polyether ester amide (A) and 99 to 60 wt % of at least one thermoplastic resin (B) selected from styrene based resins, further containing (C) 0.1-10% of a modified vinyl polymer containing carboxyl groups, are permanently antistatic, excellent in mechanical properties represented by impact resistance, heat resistance moldability and also in the appearance and gloss of the moldings, and suitable for housings of optical or magnetic recording media.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: March 23, 1999
    Assignee: Toray Industries, Inc.
    Inventors: Tadao Fukumoto, Masatoshi Iwamoto, Akihiko Kishimoto
  • Patent number: 5834561
    Abstract: Thermoplastic resin compositions consisting of 1 to 40 wt % a polyether ester amide (A) and 99 to 60 wt % of at least one thermoplastic resin (B) selected from styrene based resins, further containing (C) 0.1-10% of a modified vinyl polymer containing carboxyl groups, area permanently antistatic, excellent in mechanical properties represented by impact resistance, heat resistance moldability and also in the appearance and gloss of the moldings, and suitable for housings of optical or magnetic recording media.
    Type: Grant
    Filed: November 20, 1995
    Date of Patent: November 10, 1998
    Assignee: Toray Industries, Inc.
    Inventors: Tadao Fukumoto, Masatoshi Iwamoto, Akihiko Kishimoto
  • Patent number: 5500478
    Abstract: Thermoplastic resin compositions consisting of 1 to 40 wt % a polyether ester amide (A) and 99 to 60 wt % of at least one thermoplastic resin (B) selected from styrene based resins, further containing (C) 0.1-10% of a modified vinyl polymer containing carboxyl groups, are permanently antistatic, excellent in mechanical properties represented by impact resistance, heat resistance moldability and also in the appearance and gloss of the moldings, and suitable for housings of optical or magnetic recording media.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: March 19, 1996
    Assignee: Toray Industries, Inc.
    Inventors: Tadao Fukumoto, Masatoshi Iwamoto, Akihiko Kishimoto
  • Patent number: 5338795
    Abstract: Thermoplastic resin compositions consisting of 1 to 40 wt % a polyether ester amide (A) and 99 to 60 wt % of at least one thermoplastic resin (B) selected from styrene based resins, further containing (C) 0.1-10% of a modified vinyl polymer containing carboxyl groups, are permanently antistatic, excellent in mechanical properties represented by impact resistance, heat resistance moldability and also in the appearance and gloss of the moldings, and suitable for housings of optical or magnetic recording media.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: August 16, 1994
    Assignee: Toray Industries, Inc.
    Inventors: Tadao Fukumoto, Masatoshi Iwamoto, Akihiko Kishimoto
  • Patent number: 5115456
    Abstract: A mask for exposing a wafer with radiation and its exposition method in which the radiation exposure mask is provided with at least two radiation exposure windows which each include a mask pattern of a smaller pattern area obtained by dividing a pattern area constituting an integrating circuit chip into a plurality of the areas, and a semiconductor wafer is exposed with radiation while the radiation exposure mask is intermittently moved by a distance of the size of the small pattern area.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: May 19, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Takeshi Kimura, Shinji Kuniyoshi, Akihiko Kishimoto, Takashi Soga
  • Patent number: 4889893
    Abstract: A polyphenylene sulfide resin composition having excellent impact properties is provided which comprises:(A) a polyphenylene sulfide resin and(B) an olefinic copolymer containing 60 to 99.5% by weight of an .alpha.-olefin and 0.5 to 40% by weight of a glycidyl ester of an .alpha.,.beta.-unsaturated carboxylic acid,and which is characterized in that the polyphenylene sulfide resin (A) is contacted to improve its affinity with the olefinic copolymer (B).
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: December 26, 1989
    Assignee: Toray Industries
    Inventors: Hirokazu Kobayashi, Akihiko Kishimoto
  • Patent number: 4543390
    Abstract: An antistatic resinours composition comprising (A) graft copolymers prepared by emulsion polymerization of (a) monomer mixture consisting of (i) from 50 to 100 percents by weight of monomers having polyalkylene oxide chains and (ii) from 50 to 0 percents by weight of vinyl monomers in the presence of rubbers and (B) thermoplastic resins compatible with the graft copolymers, has permanent antistatic performances, superior mechanical properties and high flowability.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: September 24, 1985
    Assignee: Toray Industries, Inc.
    Inventors: Masayuki Tanaka, Katsuharu Morioka, Akihiko Kishimoto
  • Patent number: 3981944
    Abstract: A method is provided for continuously manufacturing high impact strength thermoplastic resins comprised of the sequential steps of (a) bulk-polymerizing a monomer solution, which contains a diene type rubber polymer or a graft polymer obtained by extracting the rubber polymer particle or vinyl monomer grafted polymer particle in latex with vinyl monomers which contain 5-20 percent by weight of water at a temperature of 85.degree.-135.degree.C, while continuously stirring the solution, vaporizing the volatile components, condensing the volatile component and recycling them back to reaction mixture, until the solid content in the reaction mixture reaches 40-75 percent by weight, and thereafter (b) bulk polymerizing the resulting prepolymer solution under the condition that plug-flowing can be attained with a temperature gradient 100.degree.-170.degree.C at the top of the reaction vessel and 170.degree.-270.degree.
    Type: Grant
    Filed: June 12, 1974
    Date of Patent: September 21, 1976
    Assignee: Toray Industries, Inc.
    Inventors: Takehiko Okamoto, Akihiko Kishimoto, Ikuo Nagai, Hiroshi Sato, Hotsuma Okasaka, Masakazu Inoue
  • Patent number: 3950455
    Abstract: High impact resistant thermoplastic resins are produced in three steps: (a) graft polymerizing a minor amount of unsaturated monomer onto a major amount of diene type rubber polymer in latex form, (b) mixing the grafted diene type rubber latex with a monomer or monomers, extracting the grafted rubber polymer particles into the monomer phase and separating and discarding the water phase to obtain a grafted rubber polymer particle dispersed monomer solution, and (c) bulk polymerizing the resulting rubber polymer particle dispersed monomer solution.
    Type: Grant
    Filed: June 26, 1974
    Date of Patent: April 13, 1976
    Assignee: Toray Industries, Inc.
    Inventors: Takehiko Okamoto, Akihiko Kishimoto, Masakazu Inoue, Ikuo Nagai, Mitsunobu Otani