Abstract: A polynucleotide synthesizing apparatus comprising a storing section for storing fluid chemicals, including nucleotide reagents, solvents and the like, necessary for polynucleotide synthesis, a reactor in which the fluid chemicals react to effect the polynucleotide synthesis, a fluid supply and discharge arrangement for supplying the fluid chemicals in the storing section to the reactor and for discharging fluid chemicals from the reactor, and a control device for controlling the fluid supply and discharge arrangement. The control device comprises a programmable controller including a storage unit in which supply amount and supply/discharge sequence information for the fluid chemicals is stored. The apparatus also comprises a memory pack comprising semiconductor memory devices in which a control program and/or maintenance program is stored. The memory pack is replaceable with the storage unit of the programmable controller.

Abstract: In an apparatus for synthesizing polynucleotide including a plurality of reactors, bottles charged with reagents and solvents, and change valve means for switching passages between respective bottles and the reactors, the improvement comprises mode selector means between a pressure source and the reactors for switching liquid supply or discharge operation and distributor means for closing or opening passages connected with the reactors to selectively operate the reactors.

Abstract: A method of manufacturing a hollow fiber in which a spinning solution of cellulose ester dissolved into an organic solvent is extruded from an annular slit, and simultaneously a core liquid is introduced into the inside hollow portion of the extruded spinning solution, the core liquid being selected from the group of hydroxycarboxylic acid, derivative of hydroxycarboxylic acid, monoterpene or these mixture, or consisting of a solution of the above-described compound or mixture.