Patents by Inventor Akihiko Okumura
Akihiko Okumura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7851743Abstract: The present invention achieves an ion mobility spectrometer which is small-sized but has higher selectivity. In an interior of a drift tube, air flow moving from a detector side to an ion source side is generated, and there are arranged, in order from an upstream side of the air flow to a downstream side thereof, a first region where a flow rate increases in a flow direction, a second region where the flow rate is constant, and a third region where the flow rate decreases. Light irradiation mechanisms for dissociating an ion are provided in the second region.Type: GrantFiled: December 12, 2008Date of Patent: December 14, 2010Assignee: Hitachi, Ltd.Inventor: Akihiko Okumura
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Patent number: 7663098Abstract: A gas monitoring apparatus capable of real-time detection of a kind of chemical warfare agent, namely diphenylcyanoarsine (DC) and/or diphenylchloroarsine (DA). Atmospheric pressure chemical ionization mass spectrometry is carried out in the positive ionization mode, the total amount of DC and DA is determined from the intensity of an ion common to DC and DA, the DC concentration is determined from the intensity of an ion specific to DC, and the difference between them is regarded as the DA concentration.Type: GrantFiled: February 9, 2007Date of Patent: February 16, 2010Assignee: Hitachi, Ltd.Inventors: Yasuo Seto, Isaac Ohsawa, Hiroshi Sekiguchi, Hisashi Maruko, Yasuaki Takada, Akihiko Okumura, Hidehiro Okada, Hisashi Nagano, Izumi Waki
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Publication number: 20090184241Abstract: The present invention achieves an ion mobility spectrometer which is small-sized but has higher selectivity. In an interior of a drift tube, air flow moving from a detector side to an ion source side is generated, and there are arranged, in order from an upstream side of the air flow to a downstream side thereof, a first region where a flow rate increases in a flow direction, a second region where the flow rate is constant, and a third region where the flow rate decreases. Light irradiation mechanisms for dissociating an ion are provided in the second region.Type: ApplicationFiled: December 12, 2008Publication date: July 23, 2009Inventor: Akihiko Okumura
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Publication number: 20080054172Abstract: A gas monitoring apparatus capable of real-time detection of a kind of chemical warfare agent, namely diphenylcyanoarsine (DC) and/or diphenylchloroarsine (DA). Atmospheric pressure chemical ionization mass spectrometry is carried out in the positive ionization mode, the total amount of DC and DA is determined from the intensity of an ion common to DC and DA, the DC concentration is determined from the intensity of an ion specific to DC, and the difference between them is regarded as the DA concentration.Type: ApplicationFiled: February 9, 2007Publication date: March 6, 2008Inventors: Yasuo Seto, Isaac Ohsawa, Hiroshi Sekiguchi, Hisashi Maruko, Yasuaki Takada, Akihiko Okumura, Hidehiro Okada, Hisashi Nagano, Izumi Waki
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Patent number: 7034287Abstract: Disclosed is a mass spectrometer combining an ion trap and a TOFMS non-coaxially, wherein ion trapping efficiency, mass resolution, and CID efficiency can be maximized. The present invention relates to the mass spectrometer combining the ion trap and the TOFMS non-coaxially, having a mass filter disposed between an ion source and an ion trap and a controller for controlling the gas pressure inside the ion trap and the gas pressure inside the mass filter independently, wherein the gas pressure inside the ion trap is set to the level higher than that inside the mass filter.Type: GrantFiled: January 5, 2004Date of Patent: April 25, 2006Assignee: Hitachi, Ltd.Inventors: Akihiko Okumura, Izumi Waki
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Patent number: 6900430Abstract: A practical mass spectrometer for proteome analysis is provided. In an ion trap-connected, orthogonal acceleration type time-of-flight mass spectrometer, the mass-to-charge ratio range that may be analyzed by one procedure is increased by providing means for reducing the velocity of ions ejected from an ion trap. The efficiency in protein identification in proteome analysis is thereby improved.Type: GrantFiled: May 24, 2002Date of Patent: May 31, 2005Assignee: Hitachi, Ltd.Inventors: Akihiko Okumura, Atsumu Hirabayashi, Izumi Waki
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Patent number: 6797949Abstract: There is provided a tandem mass spectrometry that, in a quadrupole ion trap, allows small mass-number product ions to be detected without lowering the sensitivity and the resolution. In the quadrupole ion trap, ions are produced by an ion source. Next, the ions are accumulated within a 3-dimensional quadrupole electric field formed by a pair of endcap electrodes and a ring electrode. Finally, the accumulated ions are isolated and dissociated, then being detected. In this quadrupole ion trap, there are provided a mechanism for introducing a laser light, and a mechanism for generating a supplemental alternating-current electric field at the time of the ion dissociation. Moreover, the direction of the supplemental alternating-current electric field and the introduction direction of the laser light are made identical to each other.Type: GrantFiled: November 6, 2002Date of Patent: September 28, 2004Assignee: Hitachi High-Technologies CorporationInventors: Yuichiro Hashimoto, Hideki Hasegawa, Takashi Baba, Akihiko Okumura, Izumi Waki
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Patent number: 6787017Abstract: The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to removably hold and to move the wafer-shaped part. The body includes first and second electrodes for applying a voltage across both ends of passages of the wafer-shaped part to separate and remove the sample solution. The body also includes first and second buffer reservoirs conductive to passages of the wafer-shaped part at specific positions for filling buffer solution around the first and second electrodes. The system according to the present invention facilitates washing of electrophoresis passages and reduces the time and labor costs required for replacement of the fused-silica wafers and simplifies operation by allowing a plurality of sample solutions to be analyzed more quickly.Type: GrantFiled: April 6, 2001Date of Patent: September 7, 2004Assignee: Hitachi, Ltd.Inventors: Atsumu Hirabayashi, Yukiko Hirabayashi, Akihiko Okumura, Hideaki Koizumi
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Publication number: 20040164240Abstract: Disclosed is a mass spectrometer combining an ion trap and a TOFMS non-coaxially, wherein ion trapping efficiency, mass resolution, and CID efficiency can be maximized. The present invention relates to the mass spectrometer combining the ion trap and the TOFMS non-coaxially, having a mass filter disposed between an ion source and an ion trap and a controller for controlling the gas pressure inside the ion trap and the gas pressure inside the mass filter independently, wherein the gas pressure inside the ion trap is set to the level higher than that inside the mass filter.Type: ApplicationFiled: January 5, 2004Publication date: August 26, 2004Applicant: Hitachi, Ltd.Inventors: Akihiko Okumura, Izumi Waki
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Patent number: 6774359Abstract: In a sample-introduction tool in which an end of a passage is connected to a reservoir for storing a mobile phase solution, a sample-dropping orifice is provided at the passage and the mobile phase solution and a sample running off from the other end of the passage are introduced into a mass spectrometer by generating a high-speed gas stream around the other end of the passage. The mobile phase solution and the sample are nebulized by the high-speed gas stream, and the injected sample is ionized.Type: GrantFiled: February 6, 2001Date of Patent: August 10, 2004Assignee: Hitachi, Ltd.Inventors: Yukiko Hirabayashi, Atsumu Hirabayashi, Akihiko Okumura, Hideaki Koizumi
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Patent number: 6707033Abstract: In the time-of-flight mass spectrometer, after ions are accumulated in a quadrupole ion trap in a low vacuum chamber, the ions are ejected and transferred to a high vacuum chamber and are accelerated by an acceleration electrode in a direction orthogonal to the traveling direction of ions, and time of flight for the accelerated ions is measured. Total content of detected ions is calculated with a data processing unit. An ion introduction time for the next operation is determined on the basis of the obtained total ion content, the time for introduction of ions into the ion trap and a preset threshold value of the total ion content. The threshold value of total ion content is set such that the ions ejected out of the ion trap can pass through a slit formed in a partition wall for portioning the low vacuum chamber and the high vacuum chamber.Type: GrantFiled: May 28, 2003Date of Patent: March 16, 2004Assignee: Hitachi-High Technologies CorporationInventors: Akihiko Okumura, Izumi Waki
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Patent number: 6673547Abstract: A genome DNA analysis method and a genome DNA analysis system of the present invention generates multiply-charged ions with 5 or more electric charges by an ionization process using air atomization. Also, a mass spectrometric spectrum thereof is detected and compared with predicted mass spectrum patterns in the presence or absence of polymorphism to determine a base at a polymorphic point.Type: GrantFiled: August 30, 2001Date of Patent: January 6, 2004Assignee: Hitachi, Ltd.Inventors: Atsumu Hirabayashi, Min Huang, Yukiko Hirabayashi, Akihiko Okumura
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Publication number: 20030222211Abstract: In the time-of-flight mass spectrometer, after ions are accumulated in a quadrupole ion trap in a low vacuum chamber, the ions are ejected and transferred to a high vacuum chamber and are accelerated by an acceleration electrode in a direction orthogonal to the traveling direction of ions, and time of flight for the accelerated ions is measured. Total content of detected ions is calculated with a data processing unit. An ion introduction time for the next operation is determined on the basis of the obtained total ion content, the time for introduction of ions into the ion trap and a preset threshold value of the total ion content. The threshold value of total ion content is set such that the ions ejected out of the ion trap can pass through a slit formed in a partition wall for portioning the low vacuum chamber and the high vacuum chamber.Type: ApplicationFiled: May 28, 2003Publication date: December 4, 2003Inventors: Akihiko Okumura, Izumi Waki
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Publication number: 20030155507Abstract: There is provided a tandem mass spectrometry that, in a quadrupole ion trap, allows small mass-number product ions to be detected without lowering the sensitivity and the resolution. In the quadrupole ion trap, ions are produced by an ion source. Next, the ions are accumulated within a 3-dimensional quadrupole electric field formed by a pair of endcap electrodes and a ring electrode. Finally, the accumulated ions are isolated and dissociated, then being detected. In this quadrupole ion trap, there are provided a mechanism for introducing a laser light, and a mechanism for generating a supplemental alternating-current electric field at the time of the ion dissociation. Moreover, the direction of the supplemental alternating-current electric field and the introduction direction of the laser light are made identical to each other.Type: ApplicationFiled: November 6, 2002Publication date: August 21, 2003Inventors: Yuichiro Hashimoto, Hideki Hasegawa, Takashi Baba, Akihiko Okumura, Izumi Waki
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Publication number: 20030066958Abstract: A practical mass spectrometer for proteome analysis is provided. In an ion trap-connected, orthogonal acceleration type time-of-flight mass spectrometer, the mass-to-charge ratio range that may be analyzed by one procedure is increased by providing means for reducing the velocity of ions ejected from an ion trap. The efficiency in protein identification in proteome analysis is thereby improved.Type: ApplicationFiled: May 24, 2002Publication date: April 10, 2003Inventors: Akihiko Okumura, Atsumu Hirabayashi, Izumi Waki
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Publication number: 20020127566Abstract: A genome DNA analysis method and a genome DNA analysis system of the present invention generates multiply-charged ions with 5 or more electric charges by an ionization process using air atomization. Also, a mass spectrometric spectrum thereof is detected and compared with predicted mass spectrum patterns in the presence or absence of polymorphism to determine a base at a polymorphic point.Type: ApplicationFiled: August 30, 2001Publication date: September 12, 2002Inventors: Atsumu Hirabayashi, Min Huang, Yukiko Hirabayashi, Akihiko Okumura
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Patent number: 5844881Abstract: An objective lens driving device includes drive coils mounted on one of a lens holder bearing an objective lens and a stationary member; magnets mounted on the other in such a manner that said drive coils are confronted with the magnets, and the lens holder is moved in a focusing direction and a tracking direction by application of current to the drive coils; and magnetic pieces arranged in magnetic circuits including the magnets, so that magnetic attraction forces acting on the magnetic pieces produce restoring forces two-dimensionally in the focusing direction and in the tracking direction to hold the objective lens at a neutral point. The magnetic pieces are so arranged that, at the neutral point, the drive coils are confronted straightly with the magnets.Type: GrantFiled: June 23, 1995Date of Patent: December 1, 1998Assignee: Kabushiki Kaisha Sankyo Seiki SeisakushoInventors: Ikuo Kasuga, Fumio Kobayashi, Toru Kamada, Akihiko Okumura
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Patent number: D850668Type: GrantFiled: January 18, 2018Date of Patent: June 4, 2019Assignee: IRIS OHYAMA INC.Inventors: Akihiko Okumura, Hisashi Sato
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Patent number: D1013987Type: GrantFiled: April 16, 2021Date of Patent: February 6, 2024Assignee: Iris Ohyama Inc.Inventors: Kanako Tsutsumi, Akihiko Okumura
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Patent number: D1014878Type: GrantFiled: April 13, 2021Date of Patent: February 13, 2024Assignee: Iris Ohyama Inc.Inventors: Yuki Yamamoto, Kanako Tsutsumi, Akihiko Okumura