Abstract: The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

Abstract: The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

Abstract: The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

Abstract: A display system includes a projector configured to project image light and a reflector including a gripper and a reflection surface over which a reflective material having light scattering capability is uniformly disposed.

Abstract: The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

Abstract: A moving image in which a therapy target part repeatedly moves is displayed on a screen member along with a black background.

Abstract: A first expansion valve is provided in a first refrigerant circulation passage through which the refrigerant discharged from a compressor is able to circulate by passing sequentially through an external heat exchanger and an evaporator and returning to the compressor. A second expansion valve is provided in a second refrigerant circulation passage through which the refrigerant discharged from the compressor is able to circulate by passing sequentially through an auxiliary condenser and the external heat exchanger and returning to the compressor. The second expansion valve regulates the valve opening degree such that the refrigerant state at an inlet side of the compressor during a heating operation is in a range where the dryness of refrigerant is greater than or equal to 0.9 and the superheat of refrigerant is less than or equal to 5° C.

Abstract: A first expansion valve is provided in a first refrigerant circulation passage through which the refrigerant discharged from a compressor is able to circulate by passing sequentially through an external heat exchanger and an evaporator and returning to the compressor. A second expansion valve is provided in a second refrigerant circulation passage through which the refrigerant discharged from the compressor is able to circulate by passing sequentially through an auxiliary condenser and the external heat exchanger and returning to the compressor. The second expansion valve regulates the valve opening degree such that the refrigerant state at an inlet side of the compressor during a heating operation is in a range where the dryness of refrigerant is greater than or equal to 0.9 and the superheat of refrigerant is less than or equal to 5° C.

Abstract: An image display apparatus for displaying an image of an object on a screen by using a projector includes a three-dimensional image display unit having a plurality of screens overlaid but spaced apart from one another, each of the screens diffusing and reflecting part of the light incident thereon and transmitting the remainder of the light, and an image projection unit having a plurality of projectors, each of the projectors is assigned to the corresponding one of the screens and projects an image of the object on the screen. The image projection unit displays a three-dimensional image of the object in the three-dimensional image display unit by projecting on the screens the shapes of the object in sectioning positions corresponding to the positions of the screens.

Abstract: Provided are an industrial product production facility and a production method suitable for manufacturing a wide variety of products in small quantities. A production facility (P) is provided with an injection molding machine (2), a first mold exchanging machine (3), and a device (4) for automatically opening and closing molds. The injection molding machine (2) molds a synthetic resin product by using a pair of molds (1a, 1b). The first mold exchanging machine (3) moves the pair of molds (1a, 1b) in an X direction. The first mold exchanging machine (3) is moveable in a Y direction. The device (4) for automatically opening and closing molds is disposed adjacent to the first mold exchanging machine (3) and opposite to the injection molding machine (2). The device (4) for automatically opening and closing molds separates at least the pair of molds (1a, 1b) so that rust-preventive oil on molding surfaces of the molds (1a, 1b) can be either removed or applied while gripping the pair of molds.

Abstract: An image display system that includes: a projector; and a screen device that displays a projection image being a projection result from the projector. In the image display system, the screen device includes a plurality of light diffusion units each having characteristics of light transmission and characteristics of light diffusion, and among the plurality of light diffusion units, the projection image is diffused by a second light diffusion unit after passing through a first light diffusion unit.

Abstract: Provided are industrial product production facility and production method suitable for manufacturing a wide variety of products in small quantities. A production facility (P) is provided with an injection molding machine (2), a first mold exchanging machine (3), and a device (4) for automatically opening and closing molds. The injection molding machine (2) molds a synthetic resin product by using a pair of molds (1a, 1b). The first mold exchanging machine (3) moves the pair of molds (1a, 1b) in an X direction. The first mold exchanging machine (3) is moveable in a Y direction. The device (4) for automatically opening and closing molds is disposed adjacent to the first mold exchanging machine (3) and opposite to the injection molding machine (2).

Abstract: An image display apparatus for displaying an image of an object on a screen by using a projector includes a three-dimensional image display unit having a plurality of screens overlaid but spaced apart from one another, each of the screens diffusing and reflecting part of the light incident thereon and transmitting the remainder of the light, and an image projection unit having a plurality of projectors, each of the projectors is assigned to the corresponding one of the screens and projects an image of the object on the screen. The image projection unit displays a three-dimensional image of the object in the three-dimensional image display unit by projecting on the screens the shapes of the object in sectioning positions corresponding to the positions of the screens.

Abstract: An image display system that includes: a projector; and a screen device that displays a projection image being a projection result from the projector. In the image display system, the screen device includes a plurality of light diffusion units each having characteristics of light transmission and characteristics of light diffusion, and among the plurality of light diffusion units, the projection image is diffused by a second light diffusion unit after passing through a first light diffusion unit.

Abstract: A control technique is capable of adjusting a weight of a pile fabric by adjusting consumption of a pile warp at a proper range with a more simplified system. In a pile loom, a tolerance relative to a value associated with consumption of the pile warp is set, and the value associated with consumption of the pile warp is measured during a pile weaving period. If the value associated with consumption of the pile warp exceeds the tolerance, the weaving condition parameter associated with the weight of the pile is corrected in a direction to approach a target value of the weight of a pile fabric.

Abstract: A cloth-shifting-type pile loom includes a first driving mechanism for driving a first terry motion member disposed at a feeding side of the pile loom, and a second driving mechanism for driving a second terry motion member disposed at a take-up side of the pile loom. Each of the driving mechanisms includes a rocking lever that is driven in a rocking motion in a displacement direction of the corresponding terry motion member by a corresponding one of driving means. The rocking lever of the first driving mechanism and the rocking lever of the second driving mechanism have a connection member disposed therebetween such that the connection member connects the two rocking levers.

Abstract: This reed for weaving is characterized in that a plurality of reed dents each having a hollow portion in a front edge section are arranged such that the hollow portions are communicated with each other so as to form guide grooves for the weft, the depths of the hollow portions of the reed dents located at least at one end portion are made larger than the depths of the hollow portions of the other reed dents, and that the nearer the central side in the weft insert direction, the smaller the depths of the hollow portions of the reed dents are made so as to become approximate to the depths of said hollow portions of the other reed dents, and further, areas including portions corresponding to the hollow portions in the rear edge section of the reed dents are projected backward.

Abstract: An approval request communication terminal carried by a child, etc. has a program processor for performing the execution processing of various kinds of function programs. When a predetermined condition is satisfied, the approval request communication terminal makes an approval request message of the execution processing of a function program, and transmits this approval request message to an approval processing communication terminal carried by a parent, etc. When the approval processing terminal receives the approval request message, the approval processing terminal displays contents based on this message, and receives the input of a reply to this message, and makes an approval message based on the reply, and transmits this approval message to the approval request terminal.