Abstract: The present invention provides a therapeutic agent for an immune/inflammatory disease comprising an anti-human TIGIT antibody, which activates a suppressive immune checkpoint molecule (TIGIT), as an active ingredient. Also, provided is an antibody having the following characteristics a) and b): a) the third CDR of heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 4 b) the third CDR of light chain variable region comprises the amino acid sequence of SEQ ID NO: 6.

Abstract: A condition information generation device includes an acquisition unit configured to acquire physiological information of a patient, a storage unit in which a determination method for determining a condition of the patient is stored, and a generation unit configured to generate condition information on the condition of the patient based on the acquired physiological information and the determination method. The generation unit determines whether there is missing physiological information in the acquired physiological information with respect to physiological information normally used when the determination method is executed, and generates missing information indicating that there is missing physiological information in a case where there is missing.

Abstract: A metal titanium production apparatus includes: a reductor that subjects titanium tetrachloride to a reduction process in presence of bismuth and magnesium to obtain a liquid alloy containing titanium and the bismuth; a segregator that subjects the liquid alloy to a segregation process to obtain a precipitate; and a distillator that subjects the precipitate to a distillation process to obtain metal titanium, and the distillator sets an atmosphere so as to preferentially vaporize the bismuth attached to the precipitate and then sets the atmosphere so as to vaporize the bismuth forming the precipitate.

Abstract: The present invention aims to solve a problem in T-cell transfer therapy and the like, which is T-cell exhaustion, and to provide a technique to enhance T cell activity. T cells having cell surface markers of CD45RA+ and CCR7+ can be produced by culturing activated T cells in the presence of (a) a conditioned medium derived from stromal cells or (b) CXCL12.

Abstract: A carbon fiber complex material for a carbon fiber reinforced plastic composite material includes a carbon fiber material formed from a continuous carbon fiber, and carbon nanowalls formed on a surface of the continuous carbon fiber.

Abstract: A device of executing vacuum processing is provided with: a chamber including a single main chamber executing the vacuum processing and being capable of keeping the chamber in a depressurized state; a feeding roller so disposed as to hang down a reinforcement fiber in the main chamber; a winding bobbin winding the reinforcement fiber, the winding bobbin disposed in the chamber horizontally apart from the reinforcement fiber vertically hung down; and a swing body pivotally supported in the chamber to swing about a pivot and including a suspension arm capable of capturing and suspending the reinforcement fiber according to a swing motion of the swing body, the suspension arm is capable of swinging from a first position horizontally apart from the reinforcement fiber vertically hung down, via a second position for capturing the reinforcement fiber, to a third position to suspend the reinforcement fiber above the winding bobbin.

Abstract: A device of executing vacuum processing is provided with: a chamber including a single main chamber executing the vacuum processing and being capable of keeping the chamber as a whole in a depressurized state; a plurality of feeding rollers so arranged as to hang down a plurality of threads in the main chamber with keeping the threads from each other; a plurality of winding bobbins respectively winding the plurality of threads independently, the winding bobbins arranged in the chamber horizontally apart from the plurality of threads vertically hung down; and a plurality of movable arms being respectively movable in the chamber from a first position horizontally apart from the plurality of threads vertically hung down, via a second position in contact with any of the plurality of threads, to a third position to make the threads in contact be in contact with corresponding winding bobbins.

Abstract: A condition information generation device includes: an acquisition unit configured to acquire physiological information of a subject; and a generator configured to generate condition information of the subject based on the physiological information. The generator is configured to generate the condition information based on the physiological information acquired at a target time that is set arbitrarily, the target time being a time that is earlier than a time when the condition information generation device generates the condition information.

Abstract: A metal titanium production apparatus includes: a reductor that subjects titanium tetrachloride to a reduction process in presence of bismuth and magnesium to obtain a liquid alloy containing titanium and the bismuth; a segregator that subjects the liquid alloy to a segregation process to obtain a precipitate; and a distillator that subjects the precipitate to a distillation process to obtain metal titanium, and the distillator sets an atmosphere so as to preferentially vaporize the bismuth attached to the precipitate and then sets the atmosphere so as to vaporize the bismuth forming the precipitate.

Abstract: A cell culture device includes an isolator and an incubator. A connection unit is used to connect the isolator and the incubator, and is provided with: a flexible cell supply tube extending from the incubator to the isolator; and a tube support unit having a holding part holding the cell supply tube and a connection end part attached to the incubator. The tube support unit can be switched between a first configuration in which the tube support unit supports the cell supply tube such that the cell supply tube extends in a first direction and a second configuration in which the tube support unit holds the cell supply tube such that the cell supply tube extends in a second direction. The second configuration is switched to the first configuration by means of the restoring force of the tube support unit.

Abstract: A carbon fiber complex material for a carbon fiber reinforced plastic composite material includes a carbon fiber material formed from a continuous carbon fiber, and carbon nanowalls formed on a surface of the continuous carbon fiber.

Abstract: A condition change determination method and condition change determination apparatus that, when a medical person uses a method for determining a condition change of a patient, such as NEWS, can accurately determine the condition of the patient, and a program and computer readable medium that are to be used in the apparatus or the method are provided. A non-transitory computer readable medium including a program causes a computer to realize the functions of: acquiring at least one of apnea and hypopnea rates of a patient; acquiring vital signs information of the patient other than the apnea and hypopnea rates; and determining a condition change of the patient by a determination method for determining a condition change of a patient based on at least one of the apnea and hypopnea rates, and the vital signs information other than the apnea and hypopnea rates.

Abstract: In a state where a culture unit is contained in a container of an automatic cell culture device, the circulation of a culture solution in the culture unit is controlled by a control unit, and cell culture is performed in a culture tank. The culture solution is supplied from a culture solution tank, and the cell cultured by a cell collection vial, is collected. In a state where the culture unit is contained in a container of a cell culture device for transport, the circulation of the culture solution in the culture unit is controlled by the control unit, and the cell culture is performed in the culture tank. For this reason, even in a state where the culture unit is attached to the cell culture device for transport, the circulation of the culture solution is controlled, and thus, the culture of the cell is continued.

Abstract: A cell culture device includes: a culture tank of culturing a cell in a culture solution, the culture tank being in a shape in which a horizontal sectional area upwardly increases; a pump and a culture solution supply pipe, as a supply unit supplying the culture solution to the culture tank; and a control unit controlling the supply of the culture solution of the supply unit, in which the culture solution is intermittently supplied to the culture tank from the supply unit, according to the control of the control unit, and a circulation upward flow is formed in the culture solution, and thus, a plug flow of the culture solution is formed in a culture region in which the cell is retained in the culture tank.

Abstract: The disclosure relates to an oxygen reduction catalyst, an oxygen reduction electrode, and a fuel cell each of which has a carbon nanowall doped with nitrogen. According to the disclosure, the oxygen reduction catalyst, the oxygen reduction electrode and the fuel cell can be provided at low cost.

Abstract: To fabricate a metal-supported nano-graphite with easy processing. The invention includes the steps of: using carbon nanowalls formed on a substrate to produce carbon nanowall pieces which are each composed of one or plural nano-graphite domains smaller than the carbon nanowalls; mixing metal to be supported with a liquid in which the produced carbon nanowall pieces are dispersed; and injecting a reducing agent into the liquid containing the carbon nanowall pieces and metal to cause the metal to be supported on the carbon nanowall pieces.

Abstract: The present invention relates to methods for treating inflammatory diseases accompanied by bone destruction, comprising the step of administering a viral vector comprising a gene which inhibits signal transduction mediated by fibroblast growth factor-2 (FGF2)-FGF receptor 1-Ras-Raf-MAP kinase to a diseased region. Furthermore, the present invention relates to therapeutic compositions for inflammatory diseases accompanied by bone destruction, which comprise these vectors. By inhibiting FGF2 signal transduction through local administration of viral vectors, both inflammation and bone destruction in inflammatory bone destruction were simultaneously suppressed. The present invention provides disease-specific and effective therapeutic methods, and therapeutic compositions for inflammatory diseases such as osteoarthritis, for which therapy has so far been difficult.

Abstract: A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.

Abstract: A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.

Abstract: A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.