Abstract: The present invention relates to a method for producing a radioactive zirconium-labeled complex that can realize a high labeling index in a reaction between a radioactive zirconium ion and a ligand compound. The production method of the present invention includes a step of reacting a radioactive zirconium ion with a ligand compound in a reaction solution containing water to coordinate the radioactive zirconium ion. This step is performed in a state where the pH of the reaction solution is in an acidic region. The reaction solution does not contain an organic solvent but contains a water-soluble organic compound having one or two sulfo groups or carboxy groups in its structure, separately from the ligand compound.

Abstract: A method for producing a radioactive zirconium complex of the present invention includes a step of reacting a radioactive zirconium ion, a ligand compound containing DOTA or a DOTA derivative, and an additive such as hydroxybenzoic acid and a derivative thereof with one another in a reaction solution to form a radioactive zirconium complex. As the reaction solution, a reaction solution is used in which the amount of radioactivity of the radioactive zirconium ion is 60 MBq or more at the start of the reaction and the amount of radioactivity of the radioactive zirconium ion is 5 MBq or more per 1 nmol of the ligand compound at the start of the reaction.

Abstract: The production method of a radioactive metal-labeled antibody of the present invention includes a step of conducting a click reaction of a radioactive metal complex and an antibody site-specifically modified with a peptide to produce a radioactive metal-labeled antibody. The click reaction is performed between a first atomic group of the radioactive metal complex and a second atomic group directly or indirectly linked to the peptide. The second atomic group is an atomic group containing an azide group, or an atomic group containing trans-cyclooctene.

Abstract: A method for producing a radioactive metal complex includes a step of allowing a radioactive metal to react with DOTA or a derivative thereof as a ligand in a reaction liquid to form a radioactive metal complex. The reaction liquid contains water, a buffer, and a water-soluble organic solvent. The radioactive metal is 89Zr or 225Ac. The ligand may have, in the structure thereof, a group to which a peptide is linked. The content of the water-soluble organic solvent in the reaction liquid is preferably 2% by volume or more and 50% by volume or less. The radioactive metal is preferably allowed to react with the ligand in the reaction liquid at 30° C. or higher and 80° C. or lower.

Abstract: Provided are a compound represented by the following formula (1): wherein X1 represents a hydrogen atom or a halogen atom, X2 represents a fluorine atom or a nitrile group, and X3 represents a radioactive halogen atom, or a salt thereof, and a medicament including the same.

Abstract: A human-powered vehicle drive unit that reduces loss of human driving force includes an electric motor, a crankshaft, an output portion, a speed reducer, and a clutch. The electric motor is configured to assist in propulsion of a human-powered vehicle. The output portion is coupled to the crankshaft. The speed reducer reduces a rotational speed of the electric motor in multiple steps. The clutch is provided between the output portion and the speed reducer. In a case in which the crankshaft rotates in a first rotational direction, the output portion is configured to rotate in the first rotational direction. In a case in which the crankshaft rotates in a second rotational direction, the output portion is configured to rotate in the second rotational direction. The clutch is configured to transmit a rotational force of the electric motor to the output portion from the speed reducer.

Abstract: A human-powered vehicle component includes a housing and a joint provided on the housing and configured to be attached to a support of the human-powered vehicle by a fastener. The joint includes a metal base, a metal coupling portion provided on the base and coupled to the fastener, and an intermediate portion provided between the coupling portion and the base. The base includes a first material having a first standard electrode potential. The coupling portion includes a second material having a second standard electrode potential. The intermediate portion is formed by a third material having a third standard electrode potential or a fourth material having an electric insulating property. A difference of the third and first standard electric potentials and a difference of the third and second standard electrode potentials are each smaller than a difference of the first and second standard electrode potentials.

Abstract: Provided are a compound represented by the following formula (1): wherein X1 represents a hydrogen atom or a halogen atom, X2 represents a fluorine atom or a nitrile group, and X3 represents a radioactive halogen atom, or a salt thereof, and a medicament including the same.

Abstract: A human-powered vehicle drive unit that reduces loss of human driving force includes an electric motor, a crankshaft, an output portion, a speed reducer, and a clutch. The electric motor is configured to assist in propulsion of a human-powered vehicle. The output portion is coupled to the crankshaft. The speed reducer reduces a rotational speed of the electric motor in multiple steps. The clutch is provided between the output portion and the speed reducer. In a case in which the crankshaft rotates in a first rotational direction, the output portion is configured to rotate in the first rotational direction. In a case in which the crankshaft rotates in a second rotational direction, the output portion is configured to rotate in the second rotational direction. The clutch is configured to transmit a rotational force of the electric motor to the output portion from the speed reducer.

Abstract: Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.

Abstract: Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.

Abstract: Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.

Abstract: Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.

Abstract: An electrically heatable catalytic converter for internal combustion engines is provided. This catalytic converter includes a honeycomb multi-layered core member wound around an electrode. The multi-layered core member consists of a plurality of flat metal foil sheets and a plurality of corrugated metal foil sheets arranged alternately and bonded to each other for preventing the core member from telescoping in the direction of exhaust gas flow, especially, during high-load engine operation.

Abstract: An electrically heating catalytic apparatus that quickly heats catalyst to an activation temperature even when the engine is started at a low temperature below the catalyst activation temperature. The apparatus employs an electrically conductive catalyst carrier that is electrically heated. The carrier is provided with local hot spots to be energized. Since the heat is locally generated, the heat capacity of the catalyst carrier is small to shorten a temperature increasing time.

Abstract: An electrically heating catalytic apparatus that quickly heats catalyst to an activation temperature even when the engine is started at a low temperature below the catalyst activation temperature. The apparatus employs an electrically conductive catalyst carrier that is electrically heated. The carrier is provided with local hot spots to be energized. Since the heat is locally generated, the heat capacity of the catalyst carrier is small to shorten a temperature increasing time.

Abstract: An electrostrictive actuator which can be used, e.g., in a distributor type fuel injection device of a diesel engine has an electrostrictive actuator for generating an electric charge upon reception of a load and an electric circuit unit connected to the electrostrictive actuator. The electric circuit unit has an electric charge changing means for changing the electric charge of the electrostrictive actuator in the state of generation of electric charge due to a load exerted on the electrostrictive actuator and thereby constricting the electrostrictive actuator, and an electrical charging means for charging the electrostrictive actuator in the state of constriction due to the operation of the electric charge changing means when the load exerted on the electrostrictive actuator is reduced and thereby extending the electrostrictive actuator.

Abstract: An electrostrictive actuator which can be used, e.g., in a distributor type fuel injection device of a diesel engine has an electrostrictive actuator for generating an electric charge upon reception of a load and an electric circuit unit connected to the electrostrictive actuator. The electric circuit unit has an electric charge changing means for changing the electric charge of the electrostrictive actuator in the state of generation of electric charge due to a load exerted on the electrostrictive actuator and thereby constricting the electrostrictive actuator, and an electrical charging means for charging the electrostrictive actuator in the state of constriction due to the operation of the electric charge changing means when the load exerted on the electrostrictive actuator is reduced and thereby extending the electrostrictive actuator.

Abstract: A fuel injection system comprising a fuel injection pump, at least one fuel injection nozzle connected thereto, and a control device for varying the rate of injection of the system according to varying engine parameters. The control device has a variable volume chamber, the volume of which is varied by a piston located by a piezoelectric actuator. The variable volume chamber and a pumping chamber of the pump is intermittently connected by a passage which is specifically designed in such a manner that the fluid communication between the chambers, during the delivery stroke of a pump plunger, is provided only for an initial stage of the delivery stroke. A rate of injection is controlled in the initial stage to perform a pilot injection.

Abstract: A piezoelectric fuel injector for use in fuel injection systems of spark-ignition engines is provided with a normally closed valve assembly in the form of a reed valve. The valve assembly includes a valve plate having one or more outlet ports having an overall cross-sectional flow area sufficient to ensure an unobstructed flow path therethrough. The valve assembly also includes a generally flat, thin, resilient closure member cooperating with the valve set of the valve plate. The pressure wave created in the fuel in the pumping chamber upon excitation of the piezoelectric actuator propagates into the outlet ports to directly reach the thin closure member, which readily resiliently yields to permit a desired amount of fuel to be injected into the engine cylinders. The fuel injector is particularly suitable to be operated by a high-frequency drive signal in order to ensure precise metering of fuel quantity over a wide range of engine operating conditions.