Abstract: In one aspect, this invention relates to a bioactive implant comprising an electrode array; and a source of neurotrophins coupled with the electrode array for generating a neurotrophin concentration gradient that facilitates a neuro-regenerative nexus (NRN) for survival, neuronal differentiation toward spiral ganglion neurons (SGNs), and directed neurite extension of human pluripotent stem cell (hPSC)-derived SGNs. The invention in another aspect also relates to a method for realization of the NRN in conjunction with an implant, comprising coupling a source of neurotrophins with the electrode array to generate a neurotrophin concentration gradient that facilitates the NRN for survival, neuronal differentiation toward SGNs, and directed neurite extension of hPSC-derived SGNs.