Patents by Inventor Akihiro Kishimura

Akihiro Kishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10322092
    Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 18, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
  • Publication number: 20180015036
    Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
    Type: Application
    Filed: July 26, 2017
    Publication date: January 18, 2018
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Kanjiro Miyata, Sayan Chuanoi, Tomoya Suma, Makoto Oba
  • Publication number: 20180008550
    Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 11, 2018
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
  • Publication number: 20180008549
    Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 11, 2018
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
  • Patent number: 9801958
    Abstract: The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: October 31, 2017
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Kazunori Kataoka, Nobuhiro Nishiyama, Horacio Cabral, Peng Mi, Akihiro Kishimura, Yutaka Miura, Ichio Aoki, Daisuke Kokuryo, Tsuneo Saga
  • Patent number: 9782358
    Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: October 10, 2017
    Assignee: Japan Science And Technology Agency
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
  • Patent number: 9750687
    Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: September 5, 2017
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Kanjiro Miyata, Sayan Chuanoi, Tomoya Suma, Makoto Oba
  • Publication number: 20160206759
    Abstract: The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.
    Type: Application
    Filed: August 22, 2014
    Publication date: July 21, 2016
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Kazunori KATAOKA, Nobuhiro NISHIYAMA, Horacio CABRAL, Peng MI, Akihiro KISHIMURA, Yutaka MIURA, Ichio AOKI, Daisuke KOKURYO, Tsuneo SAGA
  • Publication number: 20160051484
    Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
    Type: Application
    Filed: August 28, 2015
    Publication date: February 25, 2016
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
  • Publication number: 20150258219
    Abstract: A vesicle comprising fine metal particles, which has a membrane formed from both a first polymer of (a) or (b) shown below and a second polymer of (c) or (d) shown below (with the proviso that a combination of (b) and (d) is excepted), wherein partial crosslinking occurs between a cationic segment and an anionic segment in the above polymers: First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment (b) an amino acid polymer (I) having a cationic segment Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment (d) an amino acid polymer (II) having an anionic segment.
    Type: Application
    Filed: October 11, 2013
    Publication date: September 17, 2015
    Applicants: THE UNIVERSITY OF TOKYO, TEIJIN LIMITED
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Mitsuru Sakai, Hideo Ota, Shiro Kondo, Miho Momose
  • Patent number: 9051437
    Abstract: The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 9, 2015
    Assignees: THE UNIVERSITY OF TOKYO, TEIJIN LIMITED
    Inventors: Akihiro Kishimura, Kazunori Kataoka, Stephanie Lee, Yasutaka Anraku, Aya Koide, Mitsuru Sakai, QiuMing Yu
  • Publication number: 20130202711
    Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
    Type: Application
    Filed: May 23, 2011
    Publication date: August 8, 2013
    Applicant: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Kanjiro Miyata, Sayan Chuanoi, Tomoya Suma, Makoto Oba
  • Publication number: 20130122103
    Abstract: The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.
    Type: Application
    Filed: July 27, 2011
    Publication date: May 16, 2013
    Applicants: TEIJIN LIMITED, THE UNIVERSITY OF TOKYO
    Inventors: Akihiro Kishimura, Kazunori Kataoka, Stephanie Lee, Yasutaka Anraku, Aya Koide, Mitsuru Sakai, QiuMing Yu