Abstract: The present disclosure relates to the treatment of cancer using a combination therapy comprising Compound 1 and/or tautomers thereof or a pharmaceutically acceptable salt or hydrate thereof, and a second therapy.

Abstract: The present invention relates to a method of predicting the likelihood that a patient will respond therapeutically to a pancreatic cancer treatment comprising the administration of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one (Compound 1) and/or tautomers thereof or a pharmaceutically acceptable salt or hydrate thereof, comprising the steps of: STEP (1): determining a KRAS gene mutation status of a sample from a patient, and STEP (2): predicting an increased likelihood that the patient will respond therapeutically to the pancreatic cancer treatment if the patient has the presence of KRAS gene mutation(s), and to methods of treating pancreatic cancer.

Abstract: The present disclosure relates to methods useful for determining whether to treat cancer in a patient, and treating cancer in a patient, by administering a therapeutically effective amount of Compound 1 and/or tautomers thereof or a pharmaceutically acceptable salt or hydrate thereof.

Abstract: The present invention relates to a method of predicting the likelihood that a patient will respond therapeutically to a pancreatic cancer treatment comprising the administration of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one (Compound 1) and/or tautomers thereof or a pharmaceutically acceptable salt or hydrate thereof, comprising the steps of: STEP (1): determining a KRAS gene mutation status of a sample from a patient, and STEP (2): predicting an increased likelihood that the patient will respond therapeutically to the pancreatic cancer treatment if the patient has the presence of KRAS gene mutation(s), and to methods of treating pancreatic cancer.

Abstract: A multi unit controller has a plurality of base units each of which includes a control unit connector, a base unit connector through which the base units juxtaposed to each other are connected to each other, and a plurality of control units connected to the base units respectively through the respective control unit connector, wherein the base units juxtaposed vertically.

Abstract: A processing unit is connected to another processing unit through a system bus composed of serial signal communication line and synchronization signal communication line to be able to communicate therewith. When an operation unit detects abnormal state in the processing unit, the operation unit supplies notification of detection of the abnormal state to synchronization unit. The synchronization unit transmits the received detection notification of abnormal state to the other processing unit through the synchronization signal communication line. Conversion unit receives parallel communication data from the operation unit through important signal line instead of general signal line and converts the received parallel signal into serial signal to be transmitted to the other processing unit through the serial signal communication line, thereby soundness among processing units connected to the system bus is ensured when the system bus is configured to attain serial communication.

Abstract: To obtain injection molded objects having biodegradability and excellent flame retardance and mechanical strength, the injection molded object includes a lactic acid based resin; and a metal hydroxide in a ratio of 5 to 40 mass parts per 100 mass parts of the lactic acid based resin. The metal hydroxide is surface-treated, and Na2O (w-Na2O) present on a surface of grains of the metal hydroxide is 0.1 mass % or less based on the total mass of the metal hydroxide. Preferably, the injection molded object contains an aliphatic polyester other than the lactic acid based resin or an aromatic-aliphatic polyester in a ratio of 20 to 80 mass parts per 100 mass parts of the lactic acid based resin.

Abstract: A multi unit controller has a plurality of base units each of which includes a control unit connector, a base unit connector through which the base units juxtaposed to each other are connected to each other, and a plurality of control units connected to the base units respectively through the respective control unit connector, wherein the base units juxtaposed vertically.

Abstract: When executing sequential processing such as a ladder logic, converting a program formed of an instruction set of another processor to a program executable by an own processor in software and then conducting processing lowers the real time property. In a control system, a storage unit stores a program for the own processor and a program for another processor. A processor reads data from the storage unit, executes processing described as a program, and gives an instruction to change over a method for acquiring data from the storage unit, to a conversion instruction unit according to data contents. A changeover unit is connected to the storage unit directly or via the conversion unit to change over the data acquiring method according to an instruction from the conversion instruction unit. The conversion unit converts data read from the storage unit to data executable by the processor, according to a conversion scheme.

Abstract: A processing unit is connected to another processing unit through a system bus composed of serial signal communication line and synchronization signal communication line to be able to communicate therewith. When an operation unit detects abnormal state in the processing unit, the operation unit supplies notification of detection of the abnormal state to synchronization unit. The synchronization unit transmits the received detection notification of abnormal state to the other processing unit through the synchronization signal communication line. Conversion unit receives parallel communication data from the operation unit through important signal line instead of general signal line and converts the received parallel signal into serial signal to be transmitted to the other processing unit through the serial signal communication line, thereby soundness among processing units connected to the system bus is ensured when the system bus is configured to attain serial communication.

Abstract: To obtain injection molded objects having biodegradability and excellent flame retardance and mechanical strength, the injection molded object includes a lactic acid based resin; and a metal hydroxide in a ratio of 5 to 40 mass parts per 100 mass parts of the lactic acid based resin. The metal hydroxide is surface-treated, and Na2O (w-Na2O) present on a surface of grains of the metal hydroxide is 0.1 mass % or less based on the total mass of the metal hydroxide. Preferably, the injection molded object contains an aliphatic polyester other than the lactic acid based resin or an aromatic-aliphatic polyester in a ratio of 20 to 80 mass parts per 100 mass parts of the lactic acid based resin.

Abstract: Disclosed is a resin composition that has excellent impact resistance and excellent heat resistance without substantially deteriorating biodegradability that the lactic acid based resin has inherently. The resin composition includes (A) a lactic acid based resin; (B) an aromatic aliphatic polyester having a glass transition temperature (Tg) of 0° C. or less and a heat of crystal melting (AHm) of 5 J/g to 30 J/g, and/or an aliphatic polyester other than the lactic acid based resin, having a glass transition temperature (Tg) of 0° C. or less and a heat of crystal melting (?Hm) of 5 J/g to 30 J/g, and (B) an aromatic aliphatic polyester having a glass transition temperature (Tg) of 0° C. or less and a heat of crystal melting (?Hm) of 5 J/g to 30 J/g, and/or an aliphatic polyester other than the lactic acid based resin, having a glass transition temperature (Tg) of 0C or less and a heat of crystal melting (?Hm) of 5 J/g to 30 J/g, has a content of 5 mass % to 25 mass %.

Abstract: There is provided an input/output device having of not exerting any adverse influence on other expansion devices connected to a system bus at the time of insertion or removal. An expansion device 800 comprises an electronic circuit 400 and a MOS switch 300, and is connected to a system bus (BUS) via a connector having long and short pins. The expansion device 800 two power supply systems, namely a stable power supply 250 and an unstable power supply 260. At the time of insertion or removal of the expansion device 800, power is provided to the MOS switch 300 and a high impedance maintaining circuit from the stable power supply via a pair of long pins, so as to reliably place the MOS switch 300 in a high impedance state, inside the expansion device the high impedance maintaining circuit 350 drives an open/close control terminal, and power is provided to the electronic circuit 400 from the unstable power supply 260.

Abstract: There is provided an input/output device having of not exerting any adverse influence on other expansion devices connected to a system bus at the time of insertion or removal.

Abstract: There is provided an input/output device having of not exerting any adverse influence on other expansion devices connected to a system bus at the time of insertion or removal. An expansion device 800 comprises an electronic circuit 400 and a MOS switch 300, and is connected to a system bus (BUS) via a connector having long and short pins. The expansion device 800 two power supply systems, namely a stable power supply 250 and an unstable power supply 260. At the time of insertion or removal of the expansion device 800, power is provided to the MOS switch 300 and a high impedance maintaining circuit from the stable power supply via a pair of long pins, so as to reliably place the MOS switch 300 in a high impedance state, inside the expansion device the high impedance maintaining circuit 350 drives an open/close control terminal, and power is provided to the electronic circuit 400 from the unstable power supply 260.

Abstract: There is provided an input/output device having of not exerting any adverse influence on other expansion devices connected to a system bus at the time of insertion or removal. An expansion device 800 comprises an electronic circuit 400 and a MOS switch 300, and is connected to a system bus (BUS) via a connector having long and short pins. The expansion device 800 two power supply systems, namely a stable power supply 250 and an unstable power supply 260. At the time of insertion or removal of the expansion device 800, power is provided to the MOS switch 300 and a high impedance maintaining circuit from the stable power supply via a pair of long pins, so as to reliably place the MOS switch 300 in a high impedance state, inside the expansion device the high impedance maintaining circuit 350 drives an open/close control terminal, and power is provided to the electronic circuit 400 from the unstable power supply 260.

Abstract: There is provided an input/output device which is capable of not exerting any adverse influence on other expansion devices connected to a system bus at the time of insertion or removal thereof. An expansion device 800 includes an electronic circuit 400 and a MOS switch 300 and is connected to a system bus (BUS) via a connector having long and short pins. The expansion device 800 is coupled to two power supply systems, namely a stable power supply 250 and an unstable power supply 260. At the time of insertion or removal of the expansion device 800, power is provided to the MOS switch 300 and a high impedance maintaining circuit from the stable power supply via a pair of long pins, so as to reliably place the MOS switch 300 in a high impedance state; and, inside the expansion device, the high impedance maintaining circuit 350 drives an open/close control terminal, and power is provided to the electronic circuit 400 from the unstable power supply 260.