Patents by Inventor Akihiro Tobe

Akihiro Tobe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4883822
    Abstract: An agent for regulating the motional function of the gastrointestinal tract, which contains as an active ingredient a 41-metyl-4,4a,9,10-tetrahydro-2(3H)-phenanthrenone derivative represented by the following formula I; ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group or an alkoxy group and R.sup.2 represents a hydrogen atom or an alkyl group.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: November 28, 1989
    Assignees: Arakawa Chemical Industries, Ltd., Mistubishi Kasei Corporation
    Inventors: Kohtaro Matsuo, Youichirou Ezaki, Akihiro Tobe, Satoshi Yamazaki, Kozue Enda, Mariko Kitsukawa
  • Patent number: 4880819
    Abstract: Novel 4-aminopyridine derivatives represented by the general formula (I): ##STR1## wherein A and B independently represent ##STR2## and n is an integer of 1 or 2; as well as their pharmaceutically acceptable acid addition salts are disclosed herein. The novel compounds are useful as the agent for improving impaired brain function.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: November 14, 1989
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Kunihiro Ninomiya, Ken-Ichi Saito, Shuji Morita, Akihiro Tobe, Issei Nitta
  • Patent number: 4814507
    Abstract: A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylkene; Y is -(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: March 21, 1989
    Assignee: Mitsubishi Chemical Industries, Limited
    Inventors: Akihiro Tobe, Shinichiro Fujimori, Tomoshi Yamazaki, Mamoru Sugano, Ryoji Kikumoto, Issei Nitta
  • Patent number: 4734500
    Abstract: A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylene; Y is --(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: March 29, 1988
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Akihiro Tobe, Shinichiro Fujimori, Tomoshi Yamazaki, Mamoru Sugano, Ryoji Kikumoto, Issei Nitta
  • Patent number: 4695568
    Abstract: This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): ##STR1## or salts thereof; wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R.sup.1 and R.sup.2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R.sup.3 and R.sup.4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R.sup.5 represents a member selected from(1) hydrogen or alkyl having 1 to 6 carbon atoms,(2) ##STR2## in which m is an integer of from 1 to 3 and X represents halogen, or (3) ##STR3## in which R.sup.6 represents alkyl group having 1 to 6 carbon atoms; Ar represents substituted or unsubstituted phenyl, or 2- or 3-thienyl group; and n is 2 or 3. The derivatives of the invention can be used in the treatment of the various depression disease or the higher dysfunction of the brain.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: September 22, 1987
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Kunihiro Ninomiya, Issei Nitta, Akihiro Tobe, Mitsuo Egawa, Ryoji Kikumoto
  • Patent number: 4562211
    Abstract: 2-Substituted-1-(omega-aminoalkoxy)benzenes are prepared and found useful as pharmaceutical agents, particularly as antidepressants.
    Type: Grant
    Filed: November 16, 1979
    Date of Patent: December 31, 1985
    Assignee: Mitsubishi Chemical Industries, Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Patent number: 4339580
    Abstract: Piperazinylalkoxyindanes and their pharmaceutically acceptable acid addition salts which have anti-anxiety activity and are effective as sedatives.
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: July 13, 1982
    Assignee: Mitsubishi Chemical Industries, Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Mitsuo Egawa
  • Patent number: 4310534
    Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.
    Type: Grant
    Filed: July 30, 1980
    Date of Patent: January 12, 1982
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Mitsuo Egawa, Kunihiro Ninomiya
  • Patent number: 4284637
    Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: August 18, 1981
    Assignee: Mitsubishi Chemical Ind., Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Kunihiro Ninomiya, Mitsuo Egawa
  • Patent number: 4217366
    Abstract: 2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.
    Type: Grant
    Filed: February 14, 1979
    Date of Patent: August 12, 1980
    Assignee: Mitsubishi Chemical Industries, Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Kunihiro Ninomiya, Mitsuo Egawa
  • Patent number: 4100299
    Abstract: 2-Omega-aminoalkoxydiphenylmethylmethanes have been found useful for palliating conditions of depression in warm blooded animals.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: July 11, 1978
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Patent number: 4091114
    Abstract: 2-Omega-aminoalkoxydiphenylmethanes are prepared and shown to be useful antidepressants.
    Type: Grant
    Filed: July 9, 1976
    Date of Patent: May 23, 1978
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Patent number: 4071559
    Abstract: 2-Omega-aminoalkoxydiphenyls are prepared and found useful as pharmaceutical agents, particularly as antidepressants.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: January 31, 1978
    Assignee: Mitsubishi Chemical Industries Limited
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma, Kazuo Honda
  • Patent number: 4061776
    Abstract: This invention relates to 2-omega-aminoalkoxydiphenylethers and derivatives thereof which are pharmocologically active as antidepressants.
    Type: Grant
    Filed: November 18, 1976
    Date of Patent: December 6, 1977
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Hidenobu Ikoma
  • Patent number: 4060612
    Abstract: 2-Omega-aminoalkoxydiphenyl sulfides are prepared and found useful as pharmaceutical agents, particularly as antidepressants.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: November 29, 1977
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Patent number: 4060641
    Abstract: 2-(3-Alkylaminopropoxy) diphenylmethanes have been produced and have been found to possess antidepressant activity.
    Type: Grant
    Filed: October 21, 1976
    Date of Patent: November 29, 1977
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Patent number: 4024282
    Abstract: 2-(3-Alkylaminopropoxy) diphenylmethanes have been produced and have been found to possess antidepressant activity.
    Type: Grant
    Filed: November 25, 1975
    Date of Patent: May 17, 1977
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma