Abstract: A fixing device includes a fixing belt formed in a cylindrical shape, with a lubricant applied to an inner circumferential surface, and set such that a circumferential surface rotates in a circumferential direction, a heater retention member that retains the heater, inside of the fixing belt, and a pressure member that defines a nip region, through which a recording medium is transported in a nipped state, between the pressure member and a portion of the fixing belt heated from inside by the heater, and drives the fixing belt to rotate. The heater retention member includes a first opposing face extending in a rotation axis direction of the fixing belt, and opposed to the inner circumferential surface of the fixing belt. The first opposing face includes slits aligned in the rotation axis direction of the fixing belt, and a lubricant is applied in advance inside the slits.

Abstract: An image forming apparatus includes an image forming device, a fixing belt, a heater including a main heater and two sub heaters, a pressure member, a drive device, a main temperature sensor that detects a temperature of the main heater, a sub temperature sensor that detects a temperature of only one of the two sub heaters, a controller, and an abnormality decision device that decides whether a duty ratio adopted by the controller, to control the power amount to be supplied to the two sub heaters, is an appropriate value corresponding to a transport status of the recording medium in a regular transport mode. The controller executes, when the abnormality decision device decides that the duty ratio adopted to control the power amount to be supplied to the two sub heaters is not the appropriate value, a predetermined preventive operation for suppressing an excessive temperature increase of the heater.

Abstract: An image forming apparatus includes an image forming device, a fixing device, and a controller. The fixing device includes a fixing belt, a heater, a pressure roller, a drive device, and a pressure adjustment mechanism that adjusts pressure to the nip region from the pressure roller, by switching between a normal level and a low level. When executing a print job, the controller causes the drive device to rotate the pressure roller, thereby causing the fixing belt to start to rotate, after causing the pressure adjustment mechanism to switch the pressure to the nip region to the low level, causes the pressure adjustment mechanism to switch the pressure to the nip region from the low level to the normal level, when a predetermined time has elapsed after the fixing belt started to rotate, and causes the image forming device to form an image according to the print job.

Abstract: The present invention provides a method for treating a tumor comprising administering an effective amount of an antibody which specifically binds to human CC chemokine receptor 4, human epidermal growth factor receptor 2, human CD20, or epidermal growth factor receptor, and an indoleamine 2,3-dioxygenase inhibitor to a human in need thereof, and the like.

Abstract: The present invention provides a method for treating a tumor comprising administering an effective amount of an antibody which specifically binds to human CC chemokine receptor 4, human epidermal growth factor receptor 2, human CD20, or epidermal growth factor receptor, and an indoleamine 2,3-dioxygenase inhibitor to a human in need thereof, and the like.

Abstract: The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and a cationic lipid represented by the following formula (I): wherein R1 and R2, which are the same or different, are each linear or branched alkyl, alkenyl or alkynyl having a carbon number of from 12 to 24; L1 and L2, which are the same or different, are each —CO—O— or —O—CO—; a and b, which are the same or different, are each 1 to 3; and R3 is a hydrogen atom, alkyl having a carbon number of from 1 to 6, or alkenyl having a carbon number of from 3 to 6, and the like.

Abstract: The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and a cationic lipid represented by the following formula (I): wherein R1 and R2, which are the same or different, are each linear or branched alkyl, alkenyl or alkynyl having a carbon number of from 12 to 24; L1 and L2, which are the same or different, are each —CO—O— or —O—CO—; a and b, which are the same or different, are each 1 to 3; and R3 is a hydrogen atom, alkyl having a carbon number of from 1 to 6, or alkenyl having a carbon number of from 3 to 6, and the like.