Patents by Inventor Akihiro Yoshimoto

Akihiro Yoshimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing daunomycin
    Patent number: 4592999
    Abstract: This invention is to provide a new microbial process for producing daunomycin by a mutant strain belonging to the genus Streptomyces.
    Type: Grant
    Filed: July 18, 1983
    Date of Patent: June 3, 1986
    Assignee: Sanraku Incorporated
    Inventors: Hamao Umezawa, Tomio Takeuchi, Kageaki Kouno, Tomoyuki Ishikura, Akihiro Yoshimoto, Yukio Takatsuki, Hiroyasu Tobe
  • Anthracycline antibiotics
    Patent number: 4474945
    Abstract: New anthracycline compounds, 2-hydroxyaclacinomycin B having potent antitumor activity and lower toxicity, and a process for producing 2-hydroxyaclacinomycins A, B, and N by fermentation.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: October 2, 1984
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Akihiro Yoshimoto, Hiroyasu Tobe, Tomoyuki Ishikura, Hamao Umezawa, Tomio Takeuchi
  • Anthracycline derivatives of .beta.-rhodomycinone glycosides
    Patent number: 4439603
    Abstract: New anthracycline derivatives, .beta.-rhodomycinone-RDA, .beta.-rhodomycinone-RDRs and .beta.-rhodomycinone-RD having potent anticancer activities and lower toxicities and a process for the production thereof by reduction or hydrolysis of .beta.-rhodomycinone-RDC are disclosed.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: March 27, 1984
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Hamao Umezawa, Tomio Takeuchi, Tomoyuki Ishikura, Akihiro Yoshimoto, Yasue Matsuzawa, Yukio Takatsuki
  • Anthracycline antibiotic compounds
    Patent number: 4424342
    Abstract: Disclosed are an antitumor compound having the chemical structure ##STR1## or its acid addition salts; and its preparation method which consists of treating a compound represented by the chemical structure ##STR2## whereinR is a COCH.sub.3 or CH(OH)CH.sub.3 group,by a streptomycetes strain or its mutants.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: January 3, 1984
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Yasue Matsuzawa, Tomoyuki Ishikura, Hamao Umezawa, Tomio Takeuchi
  • 2-Hydroxyaclacinomycin A and 2-hydroxyaklavinone and process for preparing same
    Patent number: 4386198
    Abstract: New anthracycline compounds, 2-hydroxyaclacinomycin A having potent antitumor activity and lower toxicity, 2-hydroxyaklavinone as an useful precursor for producing anthracycline glycosides, and a process for the production thereof by microbial conversion method are disclosed.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: May 31, 1983
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
  • Process for producing anthracycline glycosides
    Patent number: 4337312
    Abstract: The invention is to provide a new process for producing daunomycin and baumycins having potent antitumor activity and low toxicity by microbial conversion of anthracyclinones such as aklavinone and .epsilon.-rhodomycinone.
    Type: Grant
    Filed: August 26, 1980
    Date of Patent: June 29, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
  • Rhodomycin antibiotics
    Patent number: 4316011
    Abstract: New anthracycline glycoside derivatives of rhodomycin-group, .epsilon.-rhodomycin RDC, .epsilon.-isorhodomycin RDC, .beta.-rhodomycin RDC, .gamma.-rhodomycin RDC, .gamma.-rhodomycin RDRs and .beta.-pyrromycin RDC having potent anticancer activities and lower toxicities and a process for the production thereof by microbiological conversion method are disclosed.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: February 16, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Yasue Matsuzawa, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
  • Anthracycline derivatives and process for preparing the same
    Patent number: 4267312
    Abstract: New anthracycline derivatives, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin are produced by microbial transformation of .epsilon.-pyrromycinone and .epsilon.-isorhodomycinone with daunomycin-producing streptomyces and their mutants. The derivatives herein are useful as cancer chemotherapeutic agents.
    Type: Grant
    Filed: September 12, 1979
    Date of Patent: May 12, 1981
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Taiji Inui, Tomio Takeuchi, Hamao Umezawa