Patents by Inventor Akihisa Makino
Akihisa Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12186758Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.Type: GrantFiled: September 29, 2023Date of Patent: January 7, 2025Assignee: Hitachi High-Tech CorporationInventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
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Publication number: 20240272186Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: ApplicationFiled: April 25, 2024Publication date: August 15, 2024Inventors: Akihisa MAKINO, Hajime YAMAZAKI, Keiko YOSHIKAWA, Manabu ANDO, Masahiko IIJIMA
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Publication number: 20240192234Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.Type: ApplicationFiled: February 26, 2024Publication date: June 13, 2024Inventors: Chie YABUTANI, Naoto SUZUKI, Akihisa MAKINO
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Patent number: 12000849Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: GrantFiled: November 19, 2021Date of Patent: June 4, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihisa Makino, Hajime Yamazaki, Keiko Yoshikawa, Manabu Ando, Masahiko Iijima
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Patent number: 11946941Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.Type: GrantFiled: June 26, 2020Date of Patent: April 2, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Chie Yabutani, Naoto Suzuki, Akihisa Makino
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Publication number: 20240017263Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.Type: ApplicationFiled: September 29, 2023Publication date: January 18, 2024Applicant: Hitachi High-Tech CorporationInventors: Akihiro YASUI, Akihisa MAKINO, Masashi AKUTSU, Hiroyuki MISHIMA, Yoshihiro SUZUKI
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Patent number: 11826759Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.Type: GrantFiled: December 20, 2021Date of Patent: November 28, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
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Patent number: 11808671Abstract: It is necessary to efficiently agitate a small amount of sample (such as blood) and reagent (such as diluted solution) in a short time with a dispensing probe having a constant tube inner diameter. An automatic analysis device, by a dispensing probe, executes an aspiration step of aspirating a reagent from a reagent vessel; a first dispensing and aspiration step of dispensing a first liquid amount of the aspirated reagent to a reaction vessel and aspirating, from the reaction vessel, a second liquid amount of a mixed liquid obtained by mixing the reagent and the sample in the reaction vessel; and a final dispensing step of dispensing the aspirated mixed liquid and the reagent in a predetermined dispensing amount. A first liquid amount Va is less than a predetermined dispensing amount Vdil.Type: GrantFiled: March 11, 2019Date of Patent: November 7, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Sakuichiro Adachi, Kyoko Yamamoto, Chie Yabutani, Rei Konishi, Akihisa Makino
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Publication number: 20230236056Abstract: An object of the present invention is to provide a dispensing device capable of preventing bubbles from jumping out of a nozzle and realizing highly accurate dispensing even though the nozzle is moved at a high speed toward a liquid level and is decelerated and stopped at a high acceleration. The dispensing device according to the present invention starts suction of a liquid in a period from when a nozzle starts to be lowered toward a liquid level of the liquid to when an end portion of the nozzle comes into contact with the liquid level of the liquid and the lowering of the nozzle is stopped (see FIG. 6).Type: ApplicationFiled: February 2, 2021Publication date: July 27, 2023Inventors: Masaaki HIRANO, Masafumi SHIMADA, Eiichiro TAKADA, Akihisa MAKINO
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Patent number: 11579159Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.Type: GrantFiled: January 27, 2021Date of Patent: February 14, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Rei Konishi, Akihisa Makino
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Patent number: 11486887Abstract: The present invention is provided with a sample rack insertion unit 12 that is capable of holding one or more sample racks 5 having mounted therein one or more sample containers 6 accommodating a sample to be analyzed, one or more analysis devices 2, 3 for analyzing the sample accommodated in the sample containers 6, a sample rack conveyance unit 14 for conveying the sample racks 5 from the sample rack insertion unit 12 to the analysis devices 2, 3, and a control device 4 for acquiring, for each analysis device 2, 3, load information that is information expressing an operating condition of the analysis device 2, 3, and, if there is an analysis device 2, 3 for which the load information is larger than a predetermined conveyance permission value, carrying out control so as to stop the conveyance of the sample racks 5 from the sample rack insertion unit 12 to the analysis device(s) 2, 3.Type: GrantFiled: November 13, 2017Date of Patent: November 1, 2022Assignee: Hitachi High-Tech CorporationInventors: Masashi Akutsu, Akihisa Makino, Hiroyuki Mishima, Akihiro Yasui
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Publication number: 20220111391Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.Type: ApplicationFiled: December 20, 2021Publication date: April 14, 2022Inventors: Akihiro YASUI, Akihisa MAKINO, Masashi AKUTSU, Hiroyuki MISHIMA, Yoshihiro SUZUKI
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Patent number: 11293935Abstract: An automatic analysis device includes a reagent container, a reagent disk for holding the reagent container, a dispensing mechanism for dispensing a solution into the reagent container, an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and a control unit for controlling the dispensing mechanism and the inversion mixing mechanism. The inversion mixing mechanism has a rotating mechanism for rotating the reagent container and a tilting mechanism for tilting a rotating shaft of the reagent container. The reagent container has a lid which can be pierced. The lid has a tubular mechanism having an opening part formed at the tip end and extending inside the reagent container. The control unit controls the dispensing conditions of the dispensing mechanism.Type: GrantFiled: January 12, 2017Date of Patent: April 5, 2022Assignee: Hitachi High-Tech CorporationInventors: Rei Konishi, Akihisa Makino
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Publication number: 20220074959Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: ApplicationFiled: November 19, 2021Publication date: March 10, 2022Inventors: Akihisa MAKINO, Hajime YAMAZAKI, Keiko YOSHIKAWA, Manabu ANDO, Masahiko IIJIMA
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Patent number: 11268971Abstract: An automated analyzer is provided with one or more dispensing lines 109, 209 that are each for loading and unloading, at one end thereof, a sample rack 101 having placed therein one or more sample containers accommodating a sample for analysis and for conveying the sample rack back and forth from a dispensing position for dispensing the sample from the sample containers and sample rack removal parts 111, 211 that are provided adjacent to the other ends of the dispensing lines 109, 209 and provide and receive sample racks to and from the dispensing lines 109, 209. According to this configuration, it is possible to convey an urgent sample while suppressing device complexity, preventing cost from increasing, and also maintaining speed.Type: GrantFiled: January 31, 2018Date of Patent: March 8, 2022Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Akihiro Yasui
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Patent number: 11235334Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.Type: GrantFiled: July 1, 2020Date of Patent: February 1, 2022Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
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Patent number: 11209448Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: GrantFiled: July 24, 2019Date of Patent: December 28, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihisa Makino, Hajime Yamazaki, Keiko Yoshikawa, Manabu Ando, Masahiko Iijima
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Patent number: 11199559Abstract: An automatic analyzer with high processing capacity is capable of immediately measuring an emergency specimen rack. The automatic analyzer includes a conveying line for conveying a specimen rack, and an analysis unit which has a dispensing line in which a plurality of specimen racks are arranged for waiting until sample dispensing, and a sampling area for dispensing the sample to the analysis unit. A rack save area is provided in the dispensing line and at a position adjacent to the upstream side of the sampling area. When a specimen rack exists in the sampling area at the time of measuring an emergency specimen rack, a controller moves the specimen rack to the save area and positions the emergency specimen rack to be moved from a downstream side of the sampling area to the sampling area.Type: GrantFiled: October 29, 2019Date of Patent: December 14, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Akihisa Makino, Mitsuhiro Hishinuma, Toshiyuki Shimamori, Masato Ishizawa
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Patent number: 11067590Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.Type: GrantFiled: May 11, 2018Date of Patent: July 20, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Rei Konishi, Akihisa Makino
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Patent number: 11054433Abstract: An automated analyzer has a reaction disk on which a plurality of reaction vessels capable of holding sample and reagent mixtures can be placed, a first cover for covering at least a portion of the area above the reaction disk, a second cover that can be opened and closed independently from the first cover, at least one sensor for monitoring the opening and closing of the first cover, and a control unit for monitoring a signal from the sensor and carrying out control such that if the first cover has not been opened and closed during the period until a new analysis operation is started, a pre-analysis cleaning operation, blank measurement operation, or both, are skipped.Type: GrantFiled: December 2, 2016Date of Patent: July 6, 2021Assignee: Hitachi High-Tech CorporationInventors: Yuya Matsuoka, Akihisa Makino, Hajime Yamazaki