Patents by Inventor Akihisa Makino

Akihisa Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11946941
    Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: April 2, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Chie Yabutani, Naoto Suzuki, Akihisa Makino
  • Publication number: 20240017263
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Application
    Filed: September 29, 2023
    Publication date: January 18, 2024
    Applicant: Hitachi High-Tech Corporation
    Inventors: Akihiro YASUI, Akihisa MAKINO, Masashi AKUTSU, Hiroyuki MISHIMA, Yoshihiro SUZUKI
  • Patent number: 11826759
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: November 28, 2023
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
  • Patent number: 11808671
    Abstract: It is necessary to efficiently agitate a small amount of sample (such as blood) and reagent (such as diluted solution) in a short time with a dispensing probe having a constant tube inner diameter. An automatic analysis device, by a dispensing probe, executes an aspiration step of aspirating a reagent from a reagent vessel; a first dispensing and aspiration step of dispensing a first liquid amount of the aspirated reagent to a reaction vessel and aspirating, from the reaction vessel, a second liquid amount of a mixed liquid obtained by mixing the reagent and the sample in the reaction vessel; and a final dispensing step of dispensing the aspirated mixed liquid and the reagent in a predetermined dispensing amount. A first liquid amount Va is less than a predetermined dispensing amount Vdil.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: November 7, 2023
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Sakuichiro Adachi, Kyoko Yamamoto, Chie Yabutani, Rei Konishi, Akihisa Makino
  • Publication number: 20230236056
    Abstract: An object of the present invention is to provide a dispensing device capable of preventing bubbles from jumping out of a nozzle and realizing highly accurate dispensing even though the nozzle is moved at a high speed toward a liquid level and is decelerated and stopped at a high acceleration. The dispensing device according to the present invention starts suction of a liquid in a period from when a nozzle starts to be lowered toward a liquid level of the liquid to when an end portion of the nozzle comes into contact with the liquid level of the liquid and the lowering of the nozzle is stopped (see FIG. 6).
    Type: Application
    Filed: February 2, 2021
    Publication date: July 27, 2023
    Inventors: Masaaki HIRANO, Masafumi SHIMADA, Eiichiro TAKADA, Akihisa MAKINO
  • Patent number: 11579159
    Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: February 14, 2023
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Rei Konishi, Akihisa Makino
  • Patent number: 11486887
    Abstract: The present invention is provided with a sample rack insertion unit 12 that is capable of holding one or more sample racks 5 having mounted therein one or more sample containers 6 accommodating a sample to be analyzed, one or more analysis devices 2, 3 for analyzing the sample accommodated in the sample containers 6, a sample rack conveyance unit 14 for conveying the sample racks 5 from the sample rack insertion unit 12 to the analysis devices 2, 3, and a control device 4 for acquiring, for each analysis device 2, 3, load information that is information expressing an operating condition of the analysis device 2, 3, and, if there is an analysis device 2, 3 for which the load information is larger than a predetermined conveyance permission value, carrying out control so as to stop the conveyance of the sample racks 5 from the sample rack insertion unit 12 to the analysis device(s) 2, 3.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: November 1, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Masashi Akutsu, Akihisa Makino, Hiroyuki Mishima, Akihiro Yasui
  • Publication number: 20220111391
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Inventors: Akihiro YASUI, Akihisa MAKINO, Masashi AKUTSU, Hiroyuki MISHIMA, Yoshihiro SUZUKI
  • Patent number: 11293935
    Abstract: An automatic analysis device includes a reagent container, a reagent disk for holding the reagent container, a dispensing mechanism for dispensing a solution into the reagent container, an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and a control unit for controlling the dispensing mechanism and the inversion mixing mechanism. The inversion mixing mechanism has a rotating mechanism for rotating the reagent container and a tilting mechanism for tilting a rotating shaft of the reagent container. The reagent container has a lid which can be pierced. The lid has a tubular mechanism having an opening part formed at the tip end and extending inside the reagent container. The control unit controls the dispensing conditions of the dispensing mechanism.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: April 5, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Rei Konishi, Akihisa Makino
  • Publication number: 20220074959
    Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 10, 2022
    Inventors: Akihisa MAKINO, Hajime YAMAZAKI, Keiko YOSHIKAWA, Manabu ANDO, Masahiko IIJIMA
  • Patent number: 11268971
    Abstract: An automated analyzer is provided with one or more dispensing lines 109, 209 that are each for loading and unloading, at one end thereof, a sample rack 101 having placed therein one or more sample containers accommodating a sample for analysis and for conveying the sample rack back and forth from a dispensing position for dispensing the sample from the sample containers and sample rack removal parts 111, 211 that are provided adjacent to the other ends of the dispensing lines 109, 209 and provide and receive sample racks to and from the dispensing lines 109, 209. According to this configuration, it is possible to convey an urgent sample while suppressing device complexity, preventing cost from increasing, and also maintaining speed.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: March 8, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Akihiro Yasui
  • Patent number: 11235334
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: February 1, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
  • Patent number: 11209448
    Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: December 28, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihisa Makino, Hajime Yamazaki, Keiko Yoshikawa, Manabu Ando, Masahiko Iijima
  • Patent number: 11199559
    Abstract: An automatic analyzer with high processing capacity is capable of immediately measuring an emergency specimen rack. The automatic analyzer includes a conveying line for conveying a specimen rack, and an analysis unit which has a dispensing line in which a plurality of specimen racks are arranged for waiting until sample dispensing, and a sampling area for dispensing the sample to the analysis unit. A rack save area is provided in the dispensing line and at a position adjacent to the upstream side of the sampling area. When a specimen rack exists in the sampling area at the time of measuring an emergency specimen rack, a controller moves the specimen rack to the save area and positions the emergency specimen rack to be moved from a downstream side of the sampling area to the sampling area.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: December 14, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihisa Makino, Mitsuhiro Hishinuma, Toshiyuki Shimamori, Masato Ishizawa
  • Patent number: 11067590
    Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: July 20, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Rei Konishi, Akihisa Makino
  • Patent number: 11054433
    Abstract: An automated analyzer has a reaction disk on which a plurality of reaction vessels capable of holding sample and reagent mixtures can be placed, a first cover for covering at least a portion of the area above the reaction disk, a second cover that can be opened and closed independently from the first cover, at least one sensor for monitoring the opening and closing of the first cover, and a control unit for monitoring a signal from the sensor and carrying out control such that if the first cover has not been opened and closed during the period until a new analysis operation is started, a pre-analysis cleaning operation, blank measurement operation, or both, are skipped.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: July 6, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yuya Matsuoka, Akihisa Makino, Hajime Yamazaki
  • Publication number: 20210148943
    Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.
    Type: Application
    Filed: January 27, 2021
    Publication date: May 20, 2021
    Inventors: Rei KONISHI, Akihisa MAKINO
  • Patent number: 10989708
    Abstract: An automated analysis device includes: a first measurement unit having a reaction disc for retaining a plurality of reaction cells containing a mixed solution of sample and reagent on a circumference, a light source for irradiating the mixed solution contained in the reaction cells with light, and a light-receiving unit for detecting the irradiated light; a cleaning mechanism for cleaning the reaction cells having undergone measurement; disposable reaction containers for containing the mixed solution of sample and reagent; a second measurement unit that has a plurality of measurement channels for retaining the disposable reaction containers, and includes a light source for irradiating the disposable reaction containers retained in each of the plurality of measurement channels with light; a read unit for reading identification information; and a control unit for controlling an analysis condition for the sample on the basis of the information that has been read.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 27, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Chie Yabutani, Sumiko Murata, Akihisa Makino
  • Publication number: 20210025911
    Abstract: It is necessary to efficiently agitate a small amount of sample (such as blood) and reagent (such as diluted solution) in a short time with a dispensing probe having a constant tube inner diameter. An automatic analysis device, by a dispensing probe, executes an aspiration step of aspirating a reagent from a reagent vessel; a first dispensing and aspiration step of dispensing a first liquid amount of the aspirated reagent to a reaction vessel and aspirating, from the reaction vessel, a second liquid amount of a mixed liquid obtained by mixing the reagent and the sample in the reaction vessel; and a final dispensing step of dispensing the aspirated mixed liquid and the reagent in a predetermined dispensing amount. A first liquid amount Va is less than a predetermined dispensing amount Vdil.
    Type: Application
    Filed: March 11, 2019
    Publication date: January 28, 2021
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Sakuichiro ADACHI, Kyoko YAMAMOTO, Chie YABUTANI, Rei KONISHI, Akihisa MAKINO
  • Publication number: 20200330998
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventors: Akihiro YASUI, Akihisa MAKINO, Masashi AKUTSU, Hiroyuki MISHIMA, Yoshihiro SUZUKI