Abstract: A contact lens excellent in optical property, offering favorable feeling during the use thereof, and capable of continuous uses, which is composed of a hard portion in the central part and a soft portion in the periphery of the central part is provided. The contact lens comprising two kinds of polymers and having a hard portion arranged in the central part thereof and a soft portion arranged in the periphery of the central part, wherein a monomer mixture forming the hard portion contains at least one silicone-containing monomer, and the monomer mixture forming the hard portion and a monomer mixture forming the soft portion each contain at least one common hydrophilic monomer.

Abstract: A contact lens excellent in optical property, offering favorable feeling during the use thereof, and capable of continuous uses, which is composed of a hard portion in the central part and a soft portion in the periphery of the central part is provided. The contact lens comprising two kinds of polymers and having a hard portion arranged in the central part thereof and a soft portion arranged in the periphery of the central part, wherein a monomer mixture forming the hard portion contains at least one silicone-containing monomer, and the monomer mixture forming the hard portion and a monomer mixture forming the soft portion each contain at least one common hydrophilic monomer.

Abstract: A method for adhering and proliferating cell, which comprises the steps of inoculating, culturing and then killing fibroblast derived from a mammal, is provided. A culture vessel manufactured according to the steps of the method which can provide improved adhesion to cell and enhanced cell-proliferation is also provided.

Abstract: A method for adhering and proliferating cell, which comprises the steps of inoculating, culturing and then killing fibroblast derived from a mammal, is provided. A culture vessel manufactured according to the steps of the method which can provide improved adhesion to cell and enhanced cell-proliferation is also provided.

Abstract: A process for preparing a culture skin which comprises the following steps:a) a step in which a culture skin matrix comprising a collagen sponge, a collagen sheet or a collagen gel is prepared in a means having a projection to provide said matrix with a penetrating pore,b) a step in which a skin-derived cell is seeded and cultured on said matrix, andc) a step in which the culture skin is provided with a penetrating pore by the means having the projection before said culture skin covers a skin defect, if necessary, the steps a) and b) are simultaneously carried out; a culture skin matrix and a culture skin obtained thereby.

Abstract: A process for preparing a skin culture which comprises the following steps:a) a step in which a skin culture matrix comprising a collagen sponge, a collagen sheet or a collagen gel is prepared in a means having a projection to provide said matrix with a penetrating pore,b) a step in which a skin-derived cell is seeded and cultured on said matrix, andc) a step in which the skin culture is provided with a penetrating pore by the means having the projection before said skin culture covers a skin defect, if necessary, the steps a) and b) are simultaneously carried out; a skin culture matrix and a skin culture obtained thereby.

Abstract: A weight for a hard contact lens, which can be detachably attached to the peripheral edge of a hard contact lens and which has a groove of a shape corresponding to the peripheral edge of the hard contact lens, formed along the inner periphery of the weight.

Abstract: A process for producing a controlled drug-release contact lens, containing a first member which forms a front fact of the lens and a second member which forms a rear face of the lens, the first and second members defining a space in the contact lens, which entails a) preparing the first and second members from a non-crosslinked polymer; b) bonding the prepared first and second members by melt pressing; and c) crosslinking the bonded members by hydration treatment, wherein the non-crosslinked polymer is obtained from a polymerizable methoxy silicone compound and another monomer copolymerizable therewith.

Abstract: A ring for a hard contact lens, which can be detachably attached to the peripheral edge of a hard contact lens and which has a groove of a shape corresponding to the peripheral edge of the hard contact lens, formed along the inner periphery of the ring.

Abstract: A process for preparing a culture skin which comprises the following steps:a) a step in which a culture skin matrix comprising a collagen sponge, a collagen sheet or a collagen gel is prepared in a means having a projection to provide said matrix with a penetrating pore,b) a step in which a skin-derived cell is seeded and cultured on said matrix, andc) a step in which the culture skin is provided with a penetrating pore by the means having the projection before said culture skin covers a skin defect, if necessary, the steps a) and b) are simultaneously carried out; a culture skin matrix and a culture skin obtained thereby.

Abstract: A method of producing a contact lens provided with an identifying mark is disclosed. According to this method, a printing liquid is first prepared by dissolving a pigment in an organic solvent which is permeable into a lens material for the contact lens. This printing liquid is applied to a predetermined portion of a lens surface of the contact lens, such that the printing liquid permeates into an interior of the lens, thereby to form a colored region on the lens surface. The colored region thus formed consists of a first portion permeating into the interior of the lens, and a second portion protruding from the lens surface. Then, the second portion of the colored region is removed so as to smooth the lens surface, whereby the identifying mark is constituted by the first portion of the colored region.

Abstract: A method for treating the surface of an oxygen permeable hard contact lens, which comprises applying high-frequency glow discharge treatment to an oxygen permeable hard contact lens made of a copolymer consisting essentially of at least one monomer selected from the group consisting of a silicone-containing (meth)acrylate, a fluorine-containing (meth)acrylate, a silicone-containing styrene and a fluorine-containing styrene, in a gas atmosphere of at least one member selected from the group consisting of helium, neon, argon and nitrogen gas, containing substantially no oxygen.

Abstract: A method for treating the surface of an oxygen permeable hard contact lens, which comprises applying high-frequency glow discharge treatment to an oxygen permeable hard contact lens made of a copolymer consisting essentially of a silicone-containing (meth)acrylate and/or a fluorine-containing (meth)acrylate, in a gas atmosphere of at least one member selected from the group consisting of helium, neon, argon and nitrogen gas, containing substantially no oxygen.

Abstract: A contact lens material composed of a copolymer of a monomer mixture comprising, as essential monomers, from 5 to 20 parts by weight, based on 100 parts by weight of the total monomer mixture, of a hydrophilic monomer consisting of from 40 to 60 mol % of N-vinyl-2-pyrrolidone and from 40 to 60 mol % of metharylic acid and from 30 to 95 parts by weight, based on 100 parts by weight of the total monomer mixture, of at least one of a silicon-containing acrylate and a silicon-containing methacrylate.