Abstract: The present invention addresses the problem of providing a fundamental therapeutic method for renal diseases including glomerulonephritis such as IgA nephropathy. To solve this problem, the present invention pertains to an agent for increasing CD25-positive regulatory T cells in kidney, said agent comprising mesenchymal stem cells. The regulatory T cell-increasing agent of the present invention exerts a sufficient therapeutic effect even if further containing a cryopreservation liquid at a concentration of less than 5% (v/v).

Abstract: The present invention provides a method of producing a skeletal muscle cell from a pluripotent stem cell, which includes a step of expressing one or more exogenous factors selected from MyoD, Myf5 and nucleic acids encoding them on a pluripotent stem cell.

Abstract: The present invention provides a method of producing a skeletal muscle cell from a pluripotent stem cell, which includes a step of expressing one or more exogenous factors selected from MyoD, Myf5 and nucleic acids encoding them on a pluripotent stem cell.

Abstract: A correcting apparatus of a layout pattern data includes a storage unit configured to store a layout pattern data having a hierarchical structure of cells; and a processing unit configured to correct the layout pattern data. The processing unit corrects the layout pattern data in units of cells, determines whether each of the cells of the layout pattern data after the correction has a same shape as another cell, sets the cells determined to have the same shape to be an identical cell, and re-establishes a hierarchical structure of the cells after the correction.

Abstract: The present invention provides a seal portion mounted on an inner wall of a cap. When the cap is removed from the main body of the container, the seal is positioned below a position where a first screw thread is screwed to a second screw thread. The first screw thread is formed on inside or outside of an outer cylindrical wall of the main body of the container. Whereas, the second screw portion is formed on the outer circumference or the inner circumference of the outer wall portion of the cap.

Abstract: A cooling apparatus for use in a vehicle is provided in which the cooling water of the water-cooled internal combustion engine is guided into a first portion of the radiator and the cooling water of another water-cooled apparatus such as a water-cooled innercooler of a super charger is guided into a second portion of the radiator. The first radiator portion and the second radiator portion can be selectively fluidly connected so that cooling water from one radiator portion can assist cooling in the other radiator portion.

Abstract: The condenser is mounted in front of radiator by means of a mounting shroud, which includes a tubular portion for covering over an outer periphery of the condenser, a pair of vertical mounting walls provided on an inner periphery of the tubular portion, and a pair of mounting leg portions formed on an outer periphery of the tubular portion. The vertical mounting walls are securely fastened to upper and lower brackets of the condenser in a condition wherein the former contact with the latter, and the lower mounting leg portions are fitted in engaging recesses of a lower tank of the radiator while the upper mounting leg portions are securely fastened to an upper tank of the radiator. The tubular portion of the mounting shroud serves also as a wind introducing duct which prevents heated air having passed the radiator from coming around to the front of the condenser again.

Abstract: A cooling device for an internal combustion engine has an additonal water pump and a bypass conduit which bypasses the additional water pump. When the amount of heat radiation of the radiator is insufficient, the additional water pump is driven by an electric motor. When the additional water pump is not necessary, the bypass conduit is opened, so that the cooling fluid bypasses the additional pump.