Abstract: A method to recover an extracellular vesicle at a high efficiency, including (a) and (b): wherein (a) is mixing (i) an extracellular vesicle-containing sample, (ii) particles on which a substance having an affinity to extracellular vesicle membrane is immobilized, and (iii) a polymer to give a mixture solution containing (i?) target particles bound to the extracellular vesicle via the substance and (ii?) the polymer; and (b) separating the target particles from the mixture solution. The method further includes reducing a viscosity of the mixture solution between (a) and (b). A method for analyzing an extracellular vesicle. A kit having (a) a polymer, (b) a substance having an affinity to the extracellular vesicle membrane, and (c) an enzyme capable of degrading a polymer.

Abstract: A pneumatic tire with good fuel efficiency, drainage performance and uneven wear resistance is provided. A pneumatic tire has a tread surface provided with circumferential main grooves to define a center region and two side regions. The center region is provided with a first circumferential narrow groove and second circumferential narrow grooves located between the first circumferential narrow groove and the circumferential main grooves; and center rib-like land portions including first center rib-like land portions defined by the first circumferential narrow groove and the second circumferential narrow grooves, and second center rib-like land portions defined by the second circumferential narrow grooves and the circumferential main grooves. The center rib-like land portions located next to each other with the center circumferential narrow grooves being therebetween are adapted to supportingly contact with each other.

Abstract: A pneumatic tire with good fuel efficiency, drainage performance and uneven wear resistance is provided. A pneumatic tire has a tread surface provided with circumferential main grooves to define a center region and two side regions. The center region is provided with a first circumferential narrow groove and second circumferential narrow grooves located between the first circumferential narrow groove and the circumferential main grooves; and center rib-like land portions including first center rib-like land portions defined by the first circumferential narrow groove and the second circumferential narrow grooves, and second center rib-like land portions defined by the second circumferential narrow grooves and the circumferential main grooves. The center rib-like land portions located next to each other with the center circumferential narrow grooves being therebetween are adapted to supportingly contact with each other.

Abstract: According to one embodiment, a solid state imaging device includes a pixel cell including an FD node to convert a charge stored in a photodiode into a signal voltage and an amplifier transistor in which a gate is connected to the FD node, a source is connected to an output signal line, and a drain is connected to a pixel-power node, a voltage control portion including a first control transistor in which a gate sets to a first bias voltage, a source is connected to the output signal line, and a drain is connected to a first control portion-power node, a load circuit including a current source connected directly between one end of the output signal line and a source power supply node, and a control circuit which controls an operation to decide a reset voltage of the output signal line. The control circuit boosts the FD node.

Abstract: A ramp generation circuit including, a charge supply unit which generates predetermined charges every predetermined time, an integration circuit which accumulates the charges generated from the charge supply unit and converts the charges into a voltage, and, an attenuation unit which outputs, to an output terminal, a voltage obtained by attenuating a noise value of an output voltage from the integration circuit.

Abstract: A virtual machine control method and a virtual machine system are disclosed. In the case where a guest program can be operated in a plurality of address translation modes and the same guest virtual address is translated into different host real addresses in each address translation mode, the illegal access to a host real address by illegal address translation by double registration in the same page table is avoided, and the address translation mechanism is efficiently operated. A plurality of host page tables are prepared in the main storage, and one of the host page tables is selected with the change in address translation mode of the guest program. The bottom address of the selected host page table is set in the host page table register thereby to switch the host page table.

Abstract: A ramp generation circuit including, a charge supply unit which generates predetermined charges every predetermined time, an integration circuit which accumulates the charges generated from the charge supply unit and converts the charges into a voltage, and, an attenuation unit which outputs, to an output terminal, a voltage obtained by attenuating a noise value of an output voltage from the integration circuit.

Abstract: A virtual machine control method and a virtual machine system are disclosed. In the case where a guest program can be operated in a plurality of address translation modes and the same guest virtual address is translated into different host real addresses in each address translation mode, the illegal access to a host real address by illegal address translation by double registration in the same page table is avoided, and the address translation mechanism is efficiently operated. A plurality of host page tables are prepared in the main storage, and one of the host page tables is selected with the change in address translation mode of the guest program. The bottom address of the selected host page table is set in the host page table register thereby to switch the host page table.

Abstract: A solid-state image sensor comprises a photodiode which is provided in a p-type substrate or a p-type well and composed of a first n-type region for storing photoelectrically converted signal charges, a gate electrode provided above the substrate or well so as to be adjacent to one end of the photodiode, and a n-type drain provided at the surface of the substrate or well opposite to the photodiode, with the gate electrode interviewing therebetween. There is provided a second n-type region which is formed so as to be in contact with the upper part of the first n-type region on the gate electrode side and one end of which is formed to self-align with one end of the gate electrode to be part of the photodiode. This construction prevents the short-channel effect of the signal read transistor section and reduces or eradicates the left-over signal charges stored in the photodiode, thereby reducing noise and improving the sensitivity of the sensor.

Abstract: In an amplifier-type solid-state image sensor device, each unit cell comprises a photoconverter and a signal scanning circuit in an image sensing region on a semiconductor substrate, a metal film has an opening region for defining regions where light is radiated in the photoconverters of the unit cells, and a center position of the opening region of the metal film is displaced to the side of the center of the image sensing region with respect to a center portion of the photoconverter, so that the amount of light entering the center of the semiconductor chip and the peripheral portions of the semiconductor chip can be made equal, thereby obtaining substantially the same sensitivity at the center and peripheral portions of the semiconductor chip.

Abstract: A compression element located inside an enclosed compressor is disclosed for receiving a connection pipe from outside the compressor. The compressor has an opening one in one of its walls. The compression element has a bore running through it. An inlet end of the compression element is joined to the wall of the compressor at the opening. The inlet end of said bore is tapered in the form of a curved shape that spreads smoothly toward the opening. A guide pipe has one of its ends installed into the opening from outside the compressor. A connection pipe having a cooper plated exterior surface is inserted through the guide pipe, press-fitted into the inlet end of the compression element and joined to the compression element. The connection pipe has another end connected to a suction pipe for circulating a refrigerant within the compressor via the compression element.

Abstract: A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of these cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding this protein, expression vector containing the DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing the transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

Abstract: The extrusion moldability of particle-reinforced composites under fresh cition relative to the extruding pressure and extruding velocity can be pre-estimated from the cohesion and the coefficient of internal friction of the composite which can be calculated from the relationship of, when a frame divided into the upper and lower halves are filled with the composite and the upper and lower halves of the frame are displaced relative to each other in the horizontal direction under a pressure on the composite filling the frame, the shear stress of the composite against slip deformation.