Patent number: 6797706
Abstract: A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, —CO-lower alkyl, or —SO2-lower alkyl; R2: H, a (substituted) lower alkyl, —O-lower alkyl, —S-lower alkyl, —O-aryl, nitro, cyano, or the like; R3: —CO2H, —CO2-lower alkyl, -lower alkylene-CO2H, —NH2, -alkylene-NH2 or the like.
Type:
Grant
Filed:
December 10, 2001
Date of Patent:
September 28, 2004
Assignee:
Yamanouchi Pharmaceutical Co., Ltd.
Inventors:
Hiroyuki Hisamichi, Souichirou Kawazoe, Kazuhito Tanabe, Atsushi Ichikawa, Akiko Orita, Takayuki Suzuki, Kenichi Onda, Makoto Takeuchi