Abstract: Provided is a botulinum toxin producing method which is simple achieves a high toxin yield, and obtains a toxin having high specific activity. This botulinum toxin producing method includes: (A) a step in which a botulinum toxin is produced from botulinum toxin-producing bacteria in a medium, and a mixture a is obtained which contains a botulinum toxin, a bacterial component, and a nucleic acid component derived from the botulinum toxin; (B) a step in which the mixture a is subjected to the removal of the bacterial component, and a mixture b is obtained which contains a nucleic acid component and a botulinum toxin; (C) a step in which an endonuclease is added to the mixture b and a mixture c is obtained which contains a nucleic acid degradation product and a botulinum toxin; and (D) a step in which the mixture c is subjected to removal of the nucleic acid degradation product, and an isolated botulinum toxin liquid d is obtained.

Abstract: An absorbent article having a body contacting surface a garment contacting surface; and an absorbent core disposed therebetween is disclosed. The garment contacting surface has a garment contacting layer with a plurality of graphic elements. A circumferential edge of the article truncates a portion of the plurality of graphic elements.

Abstract: An absorbent article having a body contacting surface a garment contacting surface; and an absorbent core disposed therebetween is disclosed. The body contacting surface has first and second layers, with each layer having a pair of first longitudinal side edges and second longitudinal side edges, respectively. The garment contacting surface has a garment contacting layer with a plurality of graphic elements and a pair of garment layer longitudinal side edges. The absorbent core has a pair of core longitudinal side edges. Extending laterally outwardly from the article are a pair of flaps formed from a portion of the garment contacting layer and the second layer. A portion of a circumferential edge of the article is formed by each of the pair of second longitudinal side edges and the pair of garment layer longitudinal side edges.

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Abstract: An absorbent article having a body contacting surface a garment contacting surface; and an absorbent core disposed therebetween is disclosed. The body contacting surface has first and second layers, with each layer having a pair of first longitudinal side edges and second longitudinal side edges, respectively. The garment contacting surface has a garment contacting layer with a plurality of graphic elements and a pair of garment layer longitudinal side edges. The absorbent core has a pair of core longitudinal side edges. Extending laterally outwardly from the article are a pair of flaps formed from a portion of the garment contacting layer and the second layer. A portion of a circumferential edge of the article is formed by each of the pair of second longitudinal side edges and the pair of garment layer longitudinal side edges.

Abstract: An absorbent article for feminine hygiene, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. The garment contacting layer may have a graphic printed on the body facing surface or the body contacting layer may have a graphic printed on the garment facing surface. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer.

Abstract: An absorbent article for feminine hygiene, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. The garment contacting layer may have a graphic printed on the body facing surface or the body contacting layer may have a graphic printed on the garment facing surface. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer.

Abstract: This invention relates to an extract obtained from a plant of the genus Odontoglossum of the family Orchidaceae, or from a plant derived from a hybrid plant of the genus Odontoglossum and the genus Cochlioda, to a method for preparing the extract, and to an external agent for skin comprising the extract.

Abstract: An absorbent article for feminine hygiene, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. The garment contacting layer may have a graphic printed on the body facing surface or the body contacting layer may have a graphic printed on the garment facing surface. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer.

Abstract: An absorbent article for feminine hygiene, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. The garment contacting layer may have a graphic printed on the body facing surface or the body contacting layer may have a graphic printed on the garment facing surface. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer.

Abstract: The invention is directed to an absorbent article, which is preferably a sanitary napkin or a pantiliner, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. In one aspect of the invention, the garment contacting layer has a graphic printed on the body facing surface at least in a portion of the outer region. In another aspect of the invention, the body contacting layer has a graphic printed on the garment facing surface at least in a portion of the outer region. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer in the outer region.

Abstract: This invention relates to an extract obtained from a plant of the genus Odontoglossum of the family Orchidaceae, or from a plant derived from a hybrid plant of the genus Odontoglossum and the genus Cochlioda, to a method for preparing the extract, and to an external agent for skin comprising the extract.

Abstract: The present invention relates to a pectin derived from an acerola fruit or a hydrolysate thereof, comprising a complex formed of Aceronidin, which is a novel polyphenol compound. The pectin of the present invention can be used as an active ingredient of an antioxidant or a skin-whitening agent.

Abstract: The invention is directed to an absorbent article, which is preferably a sanitary napkin or a pantiliner, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. In one aspect of the invention, the garment contacting layer has a graphic printed on the body facing surface at least in a portion of the outer region. In another aspect of the invention, the body contacting layer has a graphic printed on the garment facing surface at least in a portion of the outer region. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer in the outer region.

Abstract: A method includes a component preparation step 10 of exposing local areas (damaged areas of an existing coating) of a base material of a metal component 1 to be coated, and roughening a surface of the base material to a desired surface roughness, a slurry preparation step 12 of preparing a coating slurry that contains a halide activator, a water soluble organic binder, and powder of an aluminum-containing intermetallic compound 3, an application and drying step 14 of applying the coating slurry to the damaged areas of the metal component, and then drying the areas, a packing step 16 of packing the metal component in a heat-resistant container filled with alumina powder, a diffusion treatment step 18 of retaining the heat-resistant container at high temperature in an inert atmosphere or a reducing atmosphere to diffuse aluminum onto the surface of the metal component, and a cleaning step 20 of taking out the metal component from the heat resistant container, and removing a slag from the surface of the metal co

Abstract: The invention is directed to a disposable absorbent product, comprising: a package having a transparent window; and a plurality of individually wrapped disposable absorbent articles which are stacked and contained in the package. An adhesive means is disposed between the garment facing surface of the backsheet and the wrapper sheet of the absorbent article. The adhesive means includes a plurality of adhesive sections which are spaced apart one another by at least one non-adhesive section. Each absorbent article is folded about at least one folding line that intersects the adhesive means at the non-adhesive section. The stacked absorbent articles are arranged such that the folding line of each absorbent article positions towards the transparent window of the package. As result, the adhesive means can be protected from yellowing caused by the ultraviolet light which comes in through the transparent window.

Abstract: The invention is directed to an absorbent article, which is preferably a sanitary napkin or a pantiliner, comprising: a body contacting layer; a garment contacting layer; and an absorbent core disposed between the body contacting layer and the garment contacting layer. The absorbent core has a core edge. The core edge defines a core region within the core edge and an outer region outside the core region. The body contacting layer and the garment contacting layer extend outward into the outer region and joined together in the outer region. In one aspect of the invention, the garment contacting layer has a graphic printed on the body facing surface at least in a portion of the outer region. In another aspect of the invention, the body contacting layer has a graphic printed on the garment facing surface at least in a portion of the outer region. The body contacting layer has a first light transmittance so that the graphic can be seen through the body contacting layer in the outer region.