Patents by Inventor Akiko Sukesada

Akiko Sukesada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
    Patent number: 5972648
    Abstract: Disclosed are hirudin analogs, a method of manufacture thereof, and anticoagulant compositions containing the same. Sequences Asp.sup.33 -Gly.sup.34 or Asp.sup.62 -Ala.sup.63 of naturally-occurring hirudins or their analogs were substituted as disclosed to suppress the formation of succinimide- or beta- forms, thereby yielding hirudin analogs with high stability, high anti-thrombin activity, and therapeutic potential as anticoagulants. Hirudin analogs having Val.sup.1 -Val.sup.2 of naturally-occurring hirudin substituted with Ile.sup.1 -Ile.sup.2 are preferred for their high antithrombiin activity. The invention also provides DNAs encoding the amino acid sequence of hirudin analogs, expression vectors, recombinant microogranisms, and a method of manufacturing hirudin analogs using recombinant microorganisms.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: October 26, 1999
    Assignee: Japan Energy Corporation
    Inventors: Akiko Sukesada, Satoru Misawa, Hitoshi Matsuda
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5880258
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)?In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignees: Japan Energy Corporation, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Ryo Muramatsu, Akiko Sukesada, Satoru Misawa, Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5767235
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I)?In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 16, 1998
    Assignees: Nippon Mining Company Limited, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi, Ryo Muramatsu, Akiko Sukesada, Satoru Misawa