Abstract: The subject of the present invention is to provide means to fully achieve the inhibition of cancer bone metastasis, which was accomplished through the repeated selection of agents with aiming at obtaining more beneficial effects on the inhibition of cancer bone metastasis. The invention is achieved by combining an inhibition substance of the activation of osteoclast caused by the degradation of a signaling molecule, TRAF6, in the activation of osteoclast, a suppressive substance of the differentiation from osteoclast precursor cells to mature osteoclasts, and/or a bone resorption inhibitor and/or a Cox2 synthesis inhibitor. This combination was found to have an extremely high utility for the inhibition of cancer bone metastasis.

Abstract: The present invention is aiming to provide further advantageous effects on treating pancreas cancer, thus providing the means therefor is the subject. The present invention was obtained by finding that there were differences in prognosis in accordance with intrinsic IL-12-producing ability when Novel Immunotherapy for Cancer (NITC) was conducted in targeting pancreatic cancer cases, and further finding that extremely high effects could be obtained on pancreatic cancer therapy by selecting a therapy based on examination results of the level of intrinsic IL-12-producing ability. Therefore, the present invention is to provide an examination method to predict prognostic effects in immunotherapy for pancreas cancer, comprising determination of intrinsic IL-12-producing ability, and a therapeutic agent for pancreas cancer based on that.

Abstract: There is provided a therapeutic agent for cancer mainly comprising a saccharide having an ?1?3 steric structure where an action of NKT cells on NKR-P1 (natural killer receptor P1) which is a natural killer (NK) cell antigen receptor of NKT cells in an activating ability of natural killer T (NKT) is used as an index and being used in a formulation where the activation can be sustained.

Abstract: There is provided means for increasing complete remission rates and shortening a period to complete remission and for achieving a synergistic effect with immunotherapy that is directed at bringing about enhanced effects from molecule-targeting therapeutic drugs. More specifically, an object is to achieve a synergistic effect by combining use of a novel immunotherapy for cancer that focuses on CTL activity, NKT activity, NK activity and ?VEGF and the like, and molecule-targeting therapeutic drugs, particularly tyrosine kinase inhibitors. The present invention was accomplished based on the finding that combined use of a tyrosine kinase inhibitor and an IL-12 inducer achieves a superior synergistic effect in cancer therapy.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: To provide an anticancer composition. More specifically, the anticancer composition according to the present invention was successfully provided by newly finding the fact that a composition comprising a marine yeast-derived ingredient having &bgr;1,3 glucan structure is an unprecedentedly effective IL-12 inducer and further newly discovering that the composition can hold promise of NK and NKT cell activating capabilities as a result of oral administration of a marine yeast-derived ingredient having &bgr;1,3 glucan structure.

Abstract: An object of the present invention is to provide an anticancer composition. More specifically, the anticancer composition according to the present invention was successfully provided by newly finding the fact that a composition comprising NGB or IMMUTOL, a yeast-derived ingredient having &bgr;1,3/1,6 glucan structure each, is an unprecedentedly effective IL-12 inducer and further newly discovering that the composition can hold promise of NK and NKT cell activating capabilities and tumor angiogenesis inhibiting capability as a result of oral administration of IMMUTOL (trade name), a yeast-derived ingredient having &bgr;1,3/1,6 glucan structure.

Abstract: To provide a novel method for assay of CTL activity, NKT activity and NK activity, to analyze the meaning of the test of each of the assayed results using the assay method and to find each of the significances of CTL activity, NKT activity and NK activity in cancer therapy. To be specific, the present invention has succeeded in providing a novel method for assay of CTL activity, NKT activity and NK activity, analyzed the meaning of the test of each of the assayed results using the assay method and found each of the significances of CTL activity, NKT activity and NK activity in cancer therapy whereupon a novel immunotherapy comprising the present invention has been achieved.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: There is provided a therapeutic agent for cancer mainly comprising a saccharide having an &agr;1→3 steric structure where an action of NKT cells on NKR-P1 (natural killer receptor P1) which is a natural killer (NK) cell antigen receptor of NKT cells in an activating ability of natural killer T (NKT) is used as an index and being used in a formulation where the activation can be sustained.

Abstract: There is provided a composition or a composition for oral administration which contains a mycelium fraction of a product obtained by incubation of mycelia of Ganoderma boninense as a main ingredient and induces the production of interleukin 12 (IL-12) or a supplementary food preparation for health by oral administration which is taken with an expectation of anticancer effect. There are also provided a commercial medium carrying the information concerning the above and a commercial method using the said commercial medium.

Abstract: There is provided a novel means of assaying an immune function. That is a means for assaying an immune function where a CD3CD161/V&agr;24V&bgr;11 ratio is used as an index.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.

Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.

Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.

Abstract: Polyprenyl derivatives having the general formula as the active ingredient: ##STR1## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group; and n represents an integer from 0 to 2, show excellent activity in the inhibition of the formation of inflammatory cytokines, and they exhibit an excellent therapeutic effect on inflammatory bowel diseases such as ulcerative colitis, Crohn's disease and Behcet syndrome.