Abstract: A system for self-regulating a suppressor includes an ion chromatography suppressor, a power supply for applying an electric potential to the suppressor, and a control unit configured to provide an offset voltage VOS and an applied voltage VA to the suppressor, measure a current of the suppressor responsive to the offset and applied voltages VOS and VA, determine a suppressor state of the suppressor based upon the measured current, and adjust the offset voltage VOS based upon the suppressor state. A method for self-regulating a suppressor is also disclosed.

Abstract: A system for self-regulating a suppressor includes an ion chromatography suppressor, a power supply for applying an electric potential to the suppressor, and a control unit configured to provide an offset voltage Vos and an applied voltage VA to the suppressor, measure a current of the suppressor responsive to the offset and applied voltages VOS and VA, determine a suppressor state of the suppressor based upon the measured current, and adjust the offset voltage Vos based upon the suppressor state. A method for self-regulating a suppressor is also disclosed.

Abstract: A method of determining an identity of a first analyte in a sample is described that includes passing the first analyte through a chromatographic column and detecting a signal curve of the first analyte by a chromatographic detector, wherein the signal curve includes a peak profile of the first analyte. The peak profile is defined by a plurality of measured data points configured to plot onto a signal coordinate system. The method further includes normalizing the peak profile of the first analyte to form a normalized peak profile, wherein the normalized peak profile includes scaling the plurality of measured data points, and wherein the normalized peak profile is defined by a plurality of normalized data points configured to plot onto a normalized coordinate system, and comparing the normalized peak profile of the first analyte with a normalized peak profile of a second analyte.

Abstract: A method of converting longer path cell signal data to shorter path cell signal data comprising: obtaining a longer path absorbance signal tracing and a shorter path absorbance signal tracing for at least one analyte band under the same conditions; obtaining an approximate superimposable match between the longer path absorbance signal tracing and the shorter path absorbance signal tracing using an amplitude scaling factor and one or more parameters derived from a dispersion model that accounts for dispersion differences between a short cell and a long cell; and applying the dispersion model in reverse using the derived parameters to future longer path absorbance signal traces from the longer path cell signal data to generate the shorter path cell signal data.

Abstract: Systems, methods and devices are taught for providing analytical methods for peak-shaped responses separated in time or space, including quantitation of chromatographic peaks based on a width measurement of a peak trace at a selected height as a quantitation element. Methods of treating a peak trace as a composition of exponential functions representing a leading and a trailing end are included. Methods that facilitate the detection of impurities in peak trace outputs are also included.

Abstract: Systems, methods and devices are taught for providing analytical methods for peak-shaped responses separated in time or space, including quantitation of chromatographic peaks based on a width measurement of a peak trace at a selected height as a quantitation element. Methods of treating a peak trace as a composition of exponential functions representing a leading and a trailing end are included. Methods that facilitate the detection of impurities in peak trace outputs are also included.