Patents by Inventor Akinobu Suzuki
Akinobu Suzuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8937091Abstract: The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R1 is a substituted or unsubstituted aryl or heterocyclyl group, R2, R3, and R4 are hydrogen atoms, n is 2, X is halogen, R5 and R6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R5 and R6 are not hydrogen atoms at the same time, or R5 and R6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.Type: GrantFiled: May 19, 2010Date of Patent: January 20, 2015Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Kozo Hamada, Akiko Terauchi, Shouichirou Ozaki, Jun-ichi Goto, Etsuko Ebisui, Akinobu Suzuki
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Patent number: 8853424Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.Type: GrantFiled: August 11, 2009Date of Patent: October 7, 2014Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
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Publication number: 20140256015Abstract: An objective of the present invention is to provide a caged compound that can be photoactivated selectively for specific target cell types and can be used in an individual organism. The objective can be achieved by a compound represented by general formula K-Q-X, which is prepared by binding bioactive substance X, photocleavable protecting group Q, and compound K, which can be an enzyme substrate and is dissociated from Q-X by an enzyme reaction, wherein: Q is a protecting group that is photocleaved by light with a specific wavelength and then dissociated from X, when K is not bound thereto; X is a substance that does not express bioactivity when Q is bound thereto, but expresses bioactivity when Q is dissociated therefrom; and K is dissociated from Q by the above enzyme, so as to form a compound represented by Q-X.Type: ApplicationFiled: February 25, 2014Publication date: September 11, 2014Applicant: Toho UniversityInventors: Toshiaki FURUTA, Masaki SONE, Akinobu SUZUKI, Eri OKA
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Publication number: 20140099695Abstract: An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive.Type: ApplicationFiled: April 11, 2012Publication date: April 10, 2014Applicants: HITACHI HIGH-TECHNOLOGIES CORPORATION, TOHO UNIVERSITYInventors: Toshiaki Furuta, Akinobu Suzuki, Hisashi Sugiyama, Satoshi Ozawa, Hiroko Tada
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Publication number: 20120277423Abstract: The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R1 is a substituted or unsubstituted aryl or heterocyclyl group, R2, R3, and R4 are hydrogen atoms, n is 2, X is halogen, R5 and R6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R5 and R6 are not hydrogen atoms at the same time, or R5 and R6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.Type: ApplicationFiled: May 19, 2010Publication date: November 1, 2012Inventors: Katsuhiko Mikoshiba, Kozo Hamada, Akiko Terauchi, Shouichirou Ozaki, Jun-ichi Goto, Etsuko Ebisui, Akinobu Suzuki
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Patent number: 8017809Abstract: A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for contrType: GrantFiled: November 24, 2006Date of Patent: September 13, 2011Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Shoichiro Ozaki, Akinobu Suzuki, Takeshi Nakamura, Kyoko Nakamura, legal representative, Aiko Nakamura, legal representative
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Publication number: 20110212919Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.Type: ApplicationFiled: August 11, 2009Publication date: September 1, 2011Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
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Publication number: 20100087645Abstract: A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for contrType: ApplicationFiled: November 24, 2006Publication date: April 8, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Katsuhiko Mikoshiba, Shoichiro Ozaki, Akinobu Suzuki, Takeshi Nakamura
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Patent number: 6373710Abstract: Electronic devices are provided with a high-frequency circuit board and a coaxial connector connected to external high-frequency signals to the circuit board. The lead terminal of the coaxial connector is directly soldered to a land on the circuit board to enable high-frequency signal transmission. The fixing portion, which is on one side of the circuit board and apart from the coaxial connector, has a structure such that the horizontal tension of the circuit board is relaxed. In this mounting method, repetitive tension due to differences in linear expansion coefficient does not act on the soldered portion.Type: GrantFiled: February 3, 2000Date of Patent: April 16, 2002Assignee: Mitsubishi Denki Kabushiki KaishaInventor: Akinobu Suzuki
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Patent number: 5986337Abstract: A semiconductor element module includes a package, a semiconductor element arranged on the package, and a plurality of leads provided on sides of the package so that an opening end of each the lead is oriented to the side of a package attaching plane, and serving to connect the semiconductor element to an external circuit; wherein a level differences is provided on the side of the package attaching plane of each of package sides so that a space is formed from each the plurality of leads.Type: GrantFiled: August 24, 1998Date of Patent: November 16, 1999Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Shinichi Takagi, Akinobu Suzuki
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Patent number: 5663821Abstract: An optical semiconductor device module comprising a light emitting element, an optical fiber, a light receiving element and an optical filter. The optical semiconductor module further includes a light absorbing-reflecting section for absorbing some of the stray beams which cannot pass through the optical filter, and reflecting some of such stray beams in a direction opposite to an optical axis of the beams. The light absorbing-reflecting section is present in a module casing such that it faces, on the optical axis, the light receiving element via the optical filter.Type: GrantFiled: November 22, 1995Date of Patent: September 2, 1997Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Hiroshi Suda, Takeshi Nakamura, Hirofumi Nemoto, Akinobu Suzuki
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Patent number: 5127074Abstract: An optical package includes a housing composed of two sections, a first section and a second section connectable to the first section. A laser holder is connected to the first section of the housing and adapted to hold a laser assembly. A fiber holder is connected to the second section of the housing and includes a ferrule by which an optical fiber is held. A rod lens is mounted within the housing to focus optical emission from the laser assembly on the optical fiber. The laser assembly includes a semiconductor element. Radial alignment of the semiconductor element and the laser holder is performed before the laser holder is secured to the first section of the housing. Axial alignment of the rod lens and the semiconductor element takes place while the laser holder is being fit in the first section of the housing. The second section of the housing is then moved in a radial direction relative to the optical axis of the semiconductor element and is, then, laser welded to the first section of the housing.Type: GrantFiled: February 7, 1991Date of Patent: June 30, 1992Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Hideki Watanabe, Yuji Sakazaki, Akinobu Suzuki
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Patent number: 5073047Abstract: An optical semiconductor module which is connected to an optical fiber to introduce light from an optical semiconductor element into the optical fiber. The module comprises a holder which holds the semiconductor element, a housing which has a rod lens positioned therein and to which the holder is connected by fitting engagement made between one end of the housing and one end of the holder such that the optical axis of the semiconductor element and the optical axis of the rod lens coincide with each other, and a receptacle to which the optical fiber is connected, the receptacle being connected to the other end of the housing adjustably within a plane which perpendicularly intersects the optical axis of the optical fiber such that light from the semiconductor element that passes through the rod lens enters the optical fiber.Type: GrantFiled: June 29, 1990Date of Patent: December 17, 1991Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Akinobu Suzuki, Yuji Sakazaki, Takeshi Nakamura
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Patent number: 4875752Abstract: An optical semiconductor module comprises an optical semiconductor assembly having a light transmitting aperture, a housing having a joint surface at its one end to be joined to the optical semiconductor assembly, an outer male screw portion and a first hole for receiving an optical fiber supporter at its other end, a lens held in a second hole formed in the housing so as to be in communicatively alignment with the light transmitting aperture and the first hole, wherein a slitted sleeve is placed in a hole communicated with the first hole and a dummy ferrule with an axially extendly central bore for passing light is placed between the first hole and the lens so that one end portion of the dummy ferrule is inserted in the slitted sleeve so as to be in contact with the optical fiber supporter when it is fitted.Type: GrantFiled: February 12, 1988Date of Patent: October 24, 1989Assignee: Mitsubishi Denki Kabushiki KaishaInventor: Akinobu Suzuki