Patents by Inventor Akinori Haga

Akinori Haga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediate compounds of 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
    Patent number: 5077410
    Abstract: The present invention relates to intermediate compounds to produce novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites.The present invention is based on two characters. One is the selection of acyl substituents of 2,3-dihydro-4(1H)-quinolinone at 1-position, namely propionyl, t-butylcarbonyl, benzoyl, 2-bromobenzoyl, 4-chlorobenzoyl, 2-methylbenzoyl, 2-ethylbenzoyl, 2,3-dimethoxybenzoyl, 2,4-dichlorobenzoyl, 4-chloro-2-methyl benzoyl or 2-chloro-4-nitrobenzoyl. The other is the selection of substituents and positional specificity at 6- or 7-position, namely halogen atom, methoxy, trifluoromethyl or dimethylamino group.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: December 31, 1991
    Assignees: Mochida Pharmaceutical Co., Ltd., Hodogaya Chemical Co., Ltd.
    Inventors: Ei Mochida, Akio Uemura, Kazuo Kato, Hiroki Tokunaga, Akinori Haga
  • 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof
    Patent number: 4968680
    Abstract: The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compound, processes for producing said compounds, intermediate compounds to produce said compounds and compositions containing said compounds with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites.The present invention is based on the selection of 1-acyl-7-halo-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compounds, namely heterocyclic-or fused heterocyclic- carbonyl derivatives at 1 position.The compounds of the present invention containing these substituents have potent hypotensive, antioedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: November 6, 1990
    Assignees: Mochida Pharmaceutical Co., Ltd., Hodogaya Chemical Co., Ltd.
    Inventors: Ei Mochida, Akio Uemura, Kazuo Kato, Hiroki Tokunaga, Akinori Haga
  • 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
    Patent number: 4839368
    Abstract: The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, processes for producing said derivatives, intermediate compounds to produce said derivatives, processes to produce said intermediate compounds, and compositions containing said derivatives with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites.The present invention is based on the selection of 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, namely O-sulfate, O-mesylate, O-methylphosphate and O-carboxymethyl ether, especially O-sulfate of 4-oxime.The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: June 13, 1989
    Assignees: Mochida Pharmaceutical Co., Ltd., Hodogaya Chemical Co., Ltd.
    Inventors: Ei Mochida, Akio Uemura, Kazuo Kato, Hiroki Tokunaga, Akinori Haga