Abstract: Provided is a method of quantifying a target substance present in a solvent comprises acquiring a first fluorescence decay curve and a second fluorescence decay curve to acquire some factors from the curves.

Abstract: The present invention relates to a method for detecting an amyloid ? oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1<t2?t3<t4), and determination is made to confirm the presence or absence of an amyloid ? oligomer in the test sample on the basis of the two normalized spectra, and shifting of the normalized spectrum of time period t3 to t4 towards the low wavelength side in comparison to the normalized spectrum of time period t1 to t2 indicates the presence of an amyloid ? oligomer in the test sample.

Abstract: The present invention relates to a method for detecting an amyloid ? oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1<t2?t3<t4), and determination is made to confirm the presence or absence of an amyloid ? oligomer in the test sample on the basis of the two normalized spectra, and shifting of the normalized spectrum of time period t3 to t4 towards the low wavelength side in comparison to the normalized spectrum of time period t1 to t2 indicates the presence of an amyloid ? oligomer in the test sample.

Abstract: In a pneumatic tire 10 according to the present invention, as an average sipe interval hc defined by an average interval of sipes adjacent to each other in a tire circumferential direction in a center portion block, which is a block arranged at a position including a tire equatorial line, and an average sipe interval hs is defined in a shoulder portion block, which is a block located at an ground contact end in a tire width direction, a relation of 1.05?(hs/hc)?4.00 is fulfilled.

Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.

Abstract: In a pneumatic tire 10 according to the present invention, as an average sipe interval hc defined by an average interval of sipes adjacent to each other in a tire circumferential direction in a center portion block, which is a block arranged at a position including a tire equatorial line, and an average sipe interval hs is defined in a shoulder portion block, which is a block located at an ground contact end in a tire width direction, a relation of 1.05?(hs/hc)?4.00 is fulfilled.

Abstract: A tire in which a reinforcement layer and a tread section are laminated in this order from the inside toward the outside in a radial direction of the tire. The tread section includes an inner base layer, an outer base layer, and a cap layer that are laminated in this order from the inside toward the outside in the radial direction of the tire. The cap layer is made of a material of which a modulus of elasticity and a loss tangent are lower than those of a material of the outer base layer. The inner base layer is made of a material of which a modulus of elasticity is lower than that of a material of the cap layer.

Abstract: The present invention relates to a method for detecting an amyloid ? oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1<t2?t3 <t4), and determination is made to confirm the presence or absence of an amyloid ? oligomer in the test sample on the basis of the two normalized spectra, and shifting of the normalized spectrum of time period t3 to t4 towards the low wavelength side in comparison to the normalized spectrum of time period t1 to t2 indicates the presence of an amyloid ? oligomer in the test sample.

Abstract: In a pneumatic tire 10 according to the present invention, as an average block edge component Dball is defined by an average of edge components of all blocks against a tire circumferential direction, an average sipe edge component Dsall is defined by an average of edge components of all sipes against the tire circumferential direction and an average block rigidity G is defined by an average of the rigidity of all blocks, a relation of 2.20 (mm)3/N?(Dball/Dsall)/G?4.00 (mm)3/N is fulfilled.

Abstract: In a pneumatic tire 10 according to the present invention, as an average sipe interval h is defined by an average interval of sipes adjacent to each other in a tire circumferential direction and an average pitch length L is defined by an average length of a repeating unit of blocks in the tire circumferential direction, a relation of 0.130?(h/L)?0.400 is fulfilled.

Abstract: In a pneumatic tire 10 according to the present invention, as an average block edge component Dball is defined by an average of edge components of all blocks against a tire circumferential direction and an average sipe edge component Dsall is defined by an average of edge components of all sipes against the tire circumferential direction, a relation of 0.15?(Dball/Dsall)?0.48 is fulfilled.

Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.

Abstract: A pressing unit including a pressing pin is attached to a mold, a semiconductor chip, first and second heat sinks, and solders are disposed in a cavity of the mold, a mold closing state is made, and a reflow is carried out in a state where the first and second heat sinks are pressed against first and second wall surfaces by the pressing pin to form a laminated body. After the laminated body is formed, the pressing pin is pulled out from the cavity, and a resin molded body is formed by injecting a resin.

Abstract: A tire in which a reinforcement layer and a tread section are laminated in this order from the inside toward the outside in a radial direction of the tire. The tread section includes an inner base layer, an outer base layer, and a cap layer that are laminated in this order from the inside toward the outside in the radial direction of the tire. The cap layer is made of a material of which a modulus of elasticity and a loss tangent are lower than those of a material of the outer base layer. The inner base layer is made of a material of which a modulus of elasticity is lower than that of a material of the cap layer.

Abstract: The present invention relates to a pneumatic tire that achieves both dry performance and on-snow performance. A pneumatic tire is provided with a central land portion including the tire equator plane, intermediate land portions, and outer land portions. The central land portion is defined as a rib by a pair of central circumferential grooves and is provided with central sipes extending linearly in the tire width direction. Each intermediate land portion is divided into blocks by intermediate inclined grooves that extend obliquely with respect to the tire circumferential direction and provide communication between one of the central circumferential grooves and an outer circumferential groove, and each intermediate land portion is provided with intermediate sipes inclined at an angle of 0° to 30° with respect to the tire width direction.

Abstract: A portable information terminal includes a first unit, a second unit, an engaging mechanism configured to engage the second unit to be slidable with respect to the first unit, a locking mechanism configured to lock the second unit slid by the engaging mechanism at a intermediate position of a slidable range, a detect unit configured to detect a lock position where the second unit is locked, and a first control unit configured to launch a predetermined function unit in accordance with the lock position.

Abstract: A portable information terminal includes a first unit, a second unit, an engaging mechanism configured to engage the second unit to be slidable with respect to the first unit, a locking mechanism configured to lock the second unit slid by the engaging mechanism at a intermediate position of a slidable range, a detect unit configured to detect a lock position where the second unit is locked, and a first control unit configured to launch a predetermined function unit in accordance with the lock position.