Abstract: The present invention provides a conjugate comprising an antibody or antibody fragment targeting an exosome surface antigen, and an inhibitor of a gene or an expression product thereof, wherein the antibody or antibody fragment and the inhibitor of a gene or an expression product thereof are covalently bonded either directly or via a linker, or are non-covalently bonded.

Abstract: The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR.

Abstract: A target analysis method and target analyzing chip are provided to directly detect a target, such as microRNA, without performing PCR. The target analysis method of the present embodiment includes: a process in which a target in a sample, a labeled probe that binds to the target, and a carrier-binding probe that binds to the target and to a carrier, contact each other, and the target, the labeled probe, and the carrier-binding probe react to bind to each other to form a first bound body; a process in which the first bound body and the carrier contact each other, and the first bound body and the carrier react to bind to each other to form a second bound body; a process to concentrate the carrier; and a process in which the target in the sample is analyzed by detecting a label of the labeled probe bound to the concentrated carrier.

Abstract: The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR.

Abstract: A movable roof opening-closing structure rotatively opening and closing a movable roof toward backward at an outside of a vehicle body through a linkage equipped with a first link bar and a second link bar, wherein the linkage is configured with an inequilateral four-bar linkage having a fixed bar at a vehicle body side, and wherein an instant center of the movable roof against the vehicle body when the movable roof is at an entirely closing position is located at one of positions where is ahead of a front end of the movable roof and behind of a rear end of the movable roof.

Abstract: An inhibitor contains naphthyridine dimer, a naphthyridine-azaquinolone hybrid, a trinaphthyridine-azaquinolone hybrid, or a trinaphthyridine-azaquinolone hybrid derivative. In order to inhibit binding of 100 nM of RRE to 100 nM of Rev protein, for example, an inhibitor containing naphthyridine dimer is used at a molarity of 1.2 ?M to 12 ?M, an inhibitor containing the naphthyridine-azaquinolone hybrid is used at a molarity of 2 ?M to 20 ?M, or an inhibitor containing the trinaphthyridine-azaquinolone hybrid derivative is used at a molarity of 200 nM to 2 ?M. This makes it possible to effectively inhibit binding of RRE to Rev protein.

Abstract: A movable roof opening-closing structure rotatively opening and closing a movable roof toward backward at an outside of a vehicle body through a linkage equipped with a first link bar and a second link bar, wherein the linkage is configured with an inequilateral four-bar linkage having a fixed bar at a vehicle body side, and wherein an instant center of the movable roof against the vehicle body when the movable roof is at an entirely closing position is located at one of positions where is ahead of a front end of the movable roof and behind of a rear end of the movable roof.