Patents by Inventor Akio Toh-e

Akio Toh-e has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Shuttle vector
    Patent number: 5707862
    Abstract: A shuttle vector containing an yeast gene and an E. coli gene and carrying the expression control region of acid phosphatase gene of yeast, which can be recombined with various genes under control of the phosphatase promoter, to give various recombinant plasmids. The shuttle vector is useful in genetic engineering industries.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: January 13, 1998
    Assignees: Juridical Foundation The Chemi-Sero-Therapeutic Research Institute, Science and Technology Agency, Minister's Secretariat Director of Finance Division
    Inventors: Atsushi Miyanohara, Akio Toh-e, Kenichi Matsubara
  • Recombinant plasmid inserted with hepatitis B virus gene, yeast transformed with said recombinant plasmid, and production of hepatitis B virus surface antigen
    Patent number: 4778761
    Abstract: A recombinant plasmid inserted with Hepatitis B virus gene, which comprises a plasmid vector containing a yeast gene and an E. coli gene and carrying the expression control region of the repressible acid phosphatase gene of yeast and a Hepatitis B virus gene recombined thereto under control of the phosphatase promoter, a transformed yeast which is prepared by transforming a yeast with the recombinant plasmid, and a method of the production of Hepatitis B virus surface antigen in a large scale by culturing the transformed yeast in a medium. The Hepatitis B virus surface antigen prepared by the present invention has the same immunological properties as those of the natural antigen from human blood plasma and is useful for the preparation of Hepatitis B virus vaccine and diagnostic reagents.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: October 18, 1988
    Assignee: Juridical Foundation the Chemosero-Therapeutic Research Institute
    Inventors: Atsushi Miyanohara, Chikateru Nozaki, Fukusaburo Hamada, Akio Toh-e, Nobuya Ohtomo, Kenichi Matsubara