Patents by Inventor Akio Watanabe
Akio Watanabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101532Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.Type: ApplicationFiled: November 28, 2023Publication date: March 28, 2024Inventors: Hideyuki Watanabe, Takashi Kamikubo, Akio Kamikawa, Takuya Washio, Yohei Seki, Keiichiro Okuyama, Osamu Ikeda, Hiroshi Tomiyama, Yoshinori Iwai, Akihiko Nakamura, Kozo Miyasaka
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Publication number: 20230126555Abstract: A balloon catheter includes: a balloon; an outside shaft connected to a proximal end of the balloon; an inside shaft extending inside the outside shaft and into the balloon to be connected to a distal end of the balloon; and a heating member disposed in the balloon for heating a liquid in the balloon. A distance between a distal end of the outside shaft and a proximal end of the heating member is 0 mm to 5 mm.Type: ApplicationFiled: March 31, 2021Publication date: April 27, 2023Inventors: Akio Watanabe, Kota Tsukamoto
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Patent number: 11595244Abstract: A recovery support apparatus includes an index value calculation means which calculates a predetermined index value with respect to a recovery work sequence on the basis of the recovery work sequence indicating a work procedure for recovery from an abnormality that has occurred in an apparatus group constituting a communication network, and an output means which outputs the index value calculated by the index value calculation means to a predetermined output destination.Type: GrantFiled: November 1, 2019Date of Patent: February 28, 2023Assignee: Nippon Telegraph and Telephone CorporationInventors: Yoichi Matsuo, Hiroki Ikeuchi, Akio Watanabe, Takehiro Kawata, Ken Nishimatsu
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Publication number: 20220388955Abstract: A drug containing, as an active ingredient, a compound having an antagonistic activity against an EP2 receptor in the prevention and/or treatment of a disease associated with the activation of an EP2 receptor, of formula (I-A): wherein all symbols have the same meanings as those described in the specification, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 26, 2020Publication date: December 8, 2022Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Akio WATANABE, Atsushi YOSHIDA, Yasuo HIROOKA, Michael G. YANG, Ning LI
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Patent number: 11454858Abstract: An optical deflector includes: a light transmitting portion through which a light passes; and a pair of electrodes arranged to oppose to each other with the light transmitting portion interposed therebetween. The light transmitting portion is a transparent ion conductor made of a single crystal or polycrystal. The pair of electrodes apply a predetermined voltage to the light transmitting portion to move ions inside the transparent ion conductor so as to change a traveling direction of the light passing through the light transmitting portion.Type: GrantFiled: March 5, 2020Date of Patent: September 27, 2022Assignees: DENSO CORPORATION, NATIONAL INSTITUTE FOR MATERIALS SCIENCEInventors: Yosuke Suzuki, Tadaaki Nagao, Akio Watanabe
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Publication number: 20210392036Abstract: A recovery support apparatus includes an index value calculation means which calculates a predetermined index value with respect to a recovery work sequence on the basis of the recovery work sequence indicating a work procedure for recovery from an abnormality that has occurred in an apparatus group constituting a communication network, and an output means which outputs the index value calculated by the index value calculation means to a predetermined output destination.Type: ApplicationFiled: November 1, 2019Publication date: December 16, 2021Inventors: Yoichi Matsuo, Hiroki IKEUCHI, Akio WATANABE, Takehiro KAWATA, Ken Nishimatsu
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Publication number: 20210303774Abstract: A summary sentence calculation apparatus, including: input means which inputs a set of sentences; and summary sentence calculating means which calculates a summary sentence set from the set of sentences, wherein the summary sentence calculating means repetitively executes processing, until the processing ends, of selecting a predetermined sentence from the set of sentences, calculating, when the predetermined sentence is added to a new summary sentence set, an amount of increase of coverage by the summary sentence set after the addition relative to coverage by the summary sentence set prior to the addition, outputting the summary sentence set prior to the addition and ending the processing when the amount of increase is smaller than a first threshold, and adopting the summary sentence set after the addition as a new summary sentence set when the amount of increase is equal to or larger than the first threshold.Type: ApplicationFiled: August 5, 2019Publication date: September 30, 2021Inventors: Akio WATANABE, Hiroki IKEUCHI
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Publication number: 20210255945Abstract: A system state estimation apparatus to estimate a system state in a system that outputs log data upon executing a user action, includes a model generation unit configured to use log data accumulated in advance, to generate a stochastic model in which a system state and a user action are associated with log data when the user action is executed in the system state; and an action determination unit configured to determine a user action that contributes to identification of the system state in the system, based on a probability distribution of the system state and the stochastic model.Type: ApplicationFiled: June 13, 2019Publication date: August 19, 2021Inventors: Hiroki IKEUCHI, Akio WATANABE, Takehiro KAWATA
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Publication number: 20210200614Abstract: An operation sequence generating apparatus of the present invention includes: a learning unit configured to learn a relationship between information indicating states of a computer system and word strings indicating the content of operations performed on the computer system in the states; and a generation unit configured to, upon receiving information indicating a new state of the computer system, generate a word string for the new state by inputting the received information to the relationship. This therefore mitigates the operation burden required for operation of the computer system.Type: ApplicationFiled: July 18, 2019Publication date: July 1, 2021Inventors: Akio WATANABE, Hiroki IKEUCHI
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Publication number: 20200292910Abstract: An optical deflector includes; a light transmitting portion through which a light passes; and a pair of electrodes arranged to oppose to each other with the light transmitting portion interposed therebetween. The light transmitting portion is a transparent ion conductor made of a single crystal or polycrystal. The pair of electrodes apply a predetermined voltage to the light transmitting portion to move ions inside the transparent ion conductor so as to change a traveling direction of the light passing through the light transmitting portion.Type: ApplicationFiled: March 5, 2020Publication date: September 17, 2020Inventors: Yosuke SUZUKI, Tadaaki NAGAO, Akio WATANABE
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Patent number: 10572318Abstract: Techniques for extracting a set of highly correlated logs without user's prior knowledge of generation rules of logs generated by a machine. A log analysis apparatus includes: a template storage unit configured to store templates for log messages; a template determination unit configured to determine templates corresponding to log messages provided from a to-be-monitored host from the stored templates; an event candidate extraction unit configured to detect templates determined for log messages provided from the same host from the determined templates and extract a sequence of the detected templates as an event candidate; and an event extraction unit configured to extract a sequence of frequently occurring templates as an event from the extracted event candidate.Type: GrantFiled: August 20, 2015Date of Patent: February 25, 2020Assignee: NIPPON TELEGRAPH AND TELEPHONE CORPORATIONInventors: Tatsuaki Kimura, Akio Watanabe, Tsuyoshi Toyono, Ken Nishimatsu
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Patent number: 10069699Abstract: A monitoring device information analyzing device calculates a log variation amount from a log variation amount of a monitoring target device h and a log variation amount of the monitoring target device on another day, by referring to a template information storage unit storing a time at which a log message arises, the log message arising in the past, a template that is associated with an ID of the monitoring target device, and a template ID of the template to calculate the log variation amount of the monitoring target device and to obtain the log variation amount of the monitoring target device on the other day at the same time zone; obtains the log variation amount that is to be a sample; executes verification according to a statistical method, and determines the sample as an advance log, if a test statistic is greater than a predetermined threshold value.Type: GrantFiled: February 12, 2016Date of Patent: September 4, 2018Assignee: NIPPON TELEGRAPH AND TELEPHONE CORPORATIONInventors: Tatsuaki Kimura, Akio Watanabe, Tsuyoshi Toyono, Ken Nishimatsu
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Publication number: 20170228265Abstract: Techniques for extracting a set of highly correlated logs without user's prior knowledge of generation rules of logs generated by a machine. A log analysis apparatus includes: a template storage unit configured to store templates for log messages; a template determination unit configured to determine templates corresponding to log messages provided from a to-be-monitored host from the stored templates; an event candidate extraction unit configured to detect templates determined for log messages provided from the same host from the determined templates and extract a sequence of the detected templates as an event candidate; and an event extraction unit configured to extract a sequence of frequently occurring templates as an event from the extracted event candidate.Type: ApplicationFiled: August 20, 2015Publication date: August 10, 2017Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATIONInventors: Tatsuaki KIMURA, Akio WATANABE, Tsuyoshi TOYONO, Ken NISHIMATSU
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Publication number: 20160254981Abstract: A monitoring device information analyzing device calculates a log variation amount from a log variation amount of a monitoring target device h and a log variation amount of the monitoring target device on another day, by referring to a template information storage unit storing a time at which a log message arises, the log message arising in the past, a template that is associated with an ID of the monitoring target device, and a template ID of the template to calculate the log variation amount of the monitoring target device and to obtain the log variation amount of the monitoring target device on the other day at the same time zone; obtains the log variation amount that is to be a sample; executes verification according to a statistical method, and determines the sample as an advance log, if a test statistic is greater than a predetermined threshold value.Type: ApplicationFiled: February 12, 2016Publication date: September 1, 2016Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATIONInventors: Tatsuaki KIMURA, Akio WATANABE, Tsuyoshi TOYONO, Ken NISHIMATSU
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Patent number: 9332342Abstract: The invention provides a microphone amplifier circuit which enhances the SNR (signal noise ratio) and expands the dynamic range by reducing the noise level. A microphone amplifier circuit includes a preamplifier which amplifies an audio signal from a capacitor microphone, a level detection circuit which outputs a level detection signal when the level of the audio signal is in the vicinity of the noise level of the microphone amplifier circuit, and an attenuator which attenuates the level of the audio signal outputted from the preamplifier in response to the level detection signal. The preamplifier includes an operational amplifier, a feedback capacitor and a feedback resistor.Type: GrantFiled: July 3, 2013Date of Patent: May 3, 2016Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLCInventors: Masahito Kanaya, Akio Watanabe
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Publication number: 20140010384Abstract: The invention provides a microphone amplifier circuit which enhances the SNR (signal noise ratio) and expands the dynamic range by reducing the noise level. A microphone amplifier circuit includes a preamplifier which amplifies an audio signal from a capacitor microphone, a level detection circuit which outputs a level detection signal when the level of the audio signal is in the vicinity of the noise level of the microphone amplifier circuit, and an attenuator which attenuates the level of the audio signal outputted from the preamplifier in response to the level detection signal. The preamplifier includes an operational amplifier, a feedback capacitor and a feedback resistor.Type: ApplicationFiled: July 3, 2013Publication date: January 9, 2014Applicant: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLCInventors: Masahito KANAYA, Akio WATANABE
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Publication number: 20130251428Abstract: A ceramic heater according to one embodiment includes a substrate (1) composed of a ceramic, a conductive pattern (patterns (21 to 26)) formed on the substrate (1), a heating element (heating elements (41 to 45)) formed on the substrate (1) so as to be electrically connected to the patterns (21 to 26), and an overcoat layer (5) formed so as to cover at least the heating elements (41 to 45). The heating elements (41 to 45) contain graphite and an alloy composed of silver and palladium, and the percentage of the amount of graphite with respect to the total amount of the alloy and the graphite is from 16 to 47%.Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: TOSHIBA LIGHTING & TECHNOLOGY CORPORATIONInventors: Takanobu Ueno, Akio Watanabe
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Patent number: 8528304Abstract: The present invention provides a method and device for producing a content filling bottle including a bottom part that is inverted between a concave shape and a convex shape to prevent a body part from being subjected to reduced pressure deformation, the method and device being capable of efficiently producing a sanitary and high-quality content filling bottle. Contents are filled into an empty bottle 1 with an inversion part 11 projecting outwardly from the body part. A cap 6 is fitted onto an opening of the bottle 1 to seal the bottle 1. An auxiliary tool 27 is then installed on the bottom part 5 of the bottle 1. Then, the bottom part of the bottle 1 with the auxiliary tool 27 installed thereon is supported via the auxiliary tool 27. The downwardly projecting inversion part 11 is pressed up so as to be inverted and recessed inwardly into the bottle 1. Subsequently, with the opening of the bottle 1 gripped, the auxiliary tool 27 is separated from the bottle 1.Type: GrantFiled: June 26, 2007Date of Patent: September 10, 2013Assignee: Graham Packaging Company, L.P.Inventors: Shunzo Miyazaki, Yasuhiro Sato, Akio Watanabe, Masaru Kimura
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Patent number: 8336195Abstract: The invention is directed to an unfailing pickup operation of an electronic component from a component storage portion at a seam of storage tapes connected even using a connection tape and prevention of reduction in a pickup rate of an electronic component. A CPU sends a feeding command to a component feeding unit to perform a component feeding operation or the like. Then, when the CPU judges that a connection tape reaches a pickup position, the CPU drives an X axis drive motor and a Y axis drive motor to move a board recognition camera to the pickup position of the feeding unit, the camera takes an image of a storage portion of a storage tape, and a recognition processing device performs recognition processing. A correction value based on a result of this recognition processing is stored in a RAM, and a suction nozzle is moved taking this correction value into account and lowers to pick up an electronic component.Type: GrantFiled: March 19, 2010Date of Patent: December 25, 2012Assignee: Hitachi High-Tech Instruments Co., Ltd.Inventors: Akio Watanabe, Akihiro Kawai, Tetsuji Ono, Makio Kameda, Kazuyoshi Oyama, Kazuyoshi Ieizumi
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Patent number: 8181337Abstract: A method of mounting electronic components on a printed board includes providing a storage tape including a first portion and a second portion that are connected by a connection tape and containing electronic components stored therein, advancing the storage tape so that an electronic component is advanced to a component pickup position where electronic components are picked up by a suction nozzle, picking up the advanced electronic component at the component pickup position by the suction nozzle, and mounting the picked up electronic component on a printed board. The advancing of the storage tape, the picking up of the electronic component and the mounting of the electronic component are repeated, and the component pickup position is adjusted when the second portion of the storage tape is advanced to the component pickup position.Type: GrantFiled: January 6, 2009Date of Patent: May 22, 2012Assignee: Hitachi High-Tech Instruments Co., Ltd.Inventors: Akio Watanabe, Akihiro Kawai, Tetsuji Ono, Makio Kameda, Kazuyoshi Oyama