Patents by Inventor Akio Yamada

Akio Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210356877
    Abstract: A toner includes toner base particles each including: a binder resin, a colorant, and wax; and resin particles on surfaces of the toner base particles. A standard deviation of a distance between the resin particles next to each other on the surfaces of the toner base particles is less than 500 nm.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 18, 2021
    Inventors: Yasuo KAMADA, Hiroshi YAMADA, Akinori SAITOH, Akio TAKEI, Toma TAKEBAYASHI, Masahiro YUKIKAWA
  • Patent number: 11136400
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 5, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Eiji Inoue, Akio Yamada, Tomomi Kawakatsu, Toshio Imai, Maki Deguchi, Aki Nakatani
  • Patent number: 11034769
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: June 15, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Eiji Inoue, Akio Yamada, Tomomi Kawakatsu, Toshio Imai, Maki Deguchi, Aki Nakatani
  • Publication number: 20210171644
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Application
    Filed: January 8, 2021
    Publication date: June 10, 2021
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Eiji INOUE, Akio YAMADA, Tomomi KAWAKATSU, Toshio IMAI, Maki DEGUCHI, Aki NAKATANI
  • Publication number: 20210100853
    Abstract: An object of the present invention is to provide an agent for decomposing an opioid peptide or composition for decomposing an opioid peptide that does not restrict dietary habits, does not provide side reactions, even if it is daily used, and thus can be continuously used without any worries. The object is achieved by an agent for decomposing an opioid peptide or composition for decomposing an opioid peptide, pharmaceutical composition for decomposing an opioid peptide, or food or drink composition for decomposing an opioid peptide containing a Bifidobacterium bacterium, a culture of the bacterium, and/or a processed cell product of the bacterium as an active ingredient.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 8, 2021
    Applicant: MORINAGA MILK INDUSTRY CO., LTD.
    Inventors: Takuma Sakurai, Nanami Hashikura, Kanetada Shimizu, Akio Yamada
  • Publication number: 20210077548
    Abstract: Provided is a novel sleep-promoting composition. Provided is a sleep-promoting composition comprising bacteria belonging to Bifidobacterium breve as an active ingredient. The sleep-promoting composition related to the present technology may prolong a sleep time by prolonging non-REM sleep and REM sleep, reducing a spontaneous behavior amount during sleep, or reducing an awakening time during sleep. The sleep-promoting composition related to the present technology may also reduce difficulty in daytime awakening. The sleep-promoting composition related to the present technology may be used for a medical composition or a food and beverage composition.
    Type: Application
    Filed: March 22, 2019
    Publication date: March 18, 2021
    Applicant: MORINAGA MILK INDUSTRY CO., LTD.
    Inventors: Mai Murata, Junichi Minami, Akio Yamada, Tetsuya Kuhara
  • Patent number: 10947313
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: March 16, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Eiji Inoue, Akio Yamada, Tomomi Kawakatsu, Toshio Imai, Maki Deguchi, Aki Nakatani
  • Patent number: 10919105
    Abstract: Provided is a three-dimensional laminating and shaping apparatus 100 including a column unit 200 that is configured to output an electron beam EB and deflect the electron beam EB toward the front surface of a powder layer 32, an electron detector 72 that is configured to detect electrons that may be emitted in a predetermined direction from the front surface of the powder layer 32 when the powder layer 32 is irradiated with the electron beam EB, a melting judging unit 410 that is configured to generate a melting signal based on the strength of the detection signal from the electron detector 72, and a deflection controller 420 that is configured to receive the melting signal to determine the condition of the irradiation the electron beam.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: February 16, 2021
    Assignee: ADVANTEST CORPORATION
    Inventors: Shinji Sugatani, Shigeki Nishina, Jun Matsumoto, Masahiro Takizawa, Minoru Soma, Akio Yamada
  • Publication number: 20210002378
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Application
    Filed: June 29, 2020
    Publication date: January 7, 2021
    Inventors: Eiji INOUE, Akio YAMADA, Tomomi KAWAKATSU, Toshio IMAI, Maki DEGUCHI, Aki NAKATANI
  • Patent number: 10661642
    Abstract: In a back window part seal structure for a vehicle with a retractable roof wherein a weather strip is used, an outer panel provided on a deck cover includes an upper overlap portion that covers a weather strip at an upper edge of a back window from diagonally above and behind the vehicle to improve the sealing property and achieve a configuration in which the assembly failure is less likely to occur.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: May 26, 2020
    Assignee: WEBASTO JAPAN CO., LTD.
    Inventors: Koji Sawahata, Akio Yamada, Yasufumi Kawakami, Masaki Oda, Takashi Senoo, Miwa Shinohara, Keiichiro Nishiura
  • Patent number: 10589612
    Abstract: A weather strip 5 is attached to a peripheral edge of an opening 4a of a vehicle body 1?, and a deck cover 18 includes a resin outer panel 21 and an inner panel 23 joined onto a rear side of the outer panel 21. A spacer 35 is interposed between the outer panel 21 and the inner panel 23 such that a portion of the deck cover 18 provided with the spacer 35 makes contact with the weather strip 5 when the deck cover 18 is closed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 17, 2020
    Assignee: WEBASTO JAPAN CO., LTD.
    Inventors: Koji Sawahata, Akio Yamada, Syuji Yoshida, Masato Shinkawa, Takuya Nishibayashi
  • Publication number: 20200061908
    Abstract: A 3D additive manufacturing device 100 is provided, including a determination unit 116 that receives modeling data relating to a shape of a section of a 3D structure 66 and determines data of irradiation positions, beam shapes, and irradiation times of a first beam and a second beam along a continuous curve, a storage unit 118 that stores the data determined by the determination unit 116, a deflection control unit 150 that outputs the irradiation position data to a deflector 50 at a timing generated based on the irradiation time data, and a deformation element control unit 130 that outputs the beam shape data to a deformation element 30. Thus, the 3D additive manufacturing device 100 forms a 3D structure by laminating sectional layers constituted by curves in a manner of melting/solidifying a powder layer while performing irradiation with the first beam and the second beam along the continuous curve.
    Type: Application
    Filed: April 11, 2017
    Publication date: February 27, 2020
    Inventors: Akio YAMADA, Shinji SUGATANI, Minoru SOMA
  • Patent number: 10573491
    Abstract: To realize a multi-beam formation device that can stably machine a fine pattern using complementary lithography, provided is a device that deforms and deflects a beam, including an aperture layer having a first aperture that deforms and passes a beam incident thereto from a first surface side of the device and a deflection layer that passes and deflects the beam that has been passed by the aperture layer. The deflection layer includes a first electrode section having a first electrode facing a beam passing space in the deflection layer corresponding to the first aperture and a second electrode section having an extending portion that extends toward the beam passing space and is independent from an adjacent layer in the deflection layer and a second electrode facing the first electrode in a manner to sandwich the beam passing space between the first electrode and an end portion of the second electrode.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: February 25, 2020
    Assignee: ADVANTEST CORPORATION
    Inventors: Akio Yamada, Shinji Sugatani, Masaki Kurokawa, Masahiro Takizawa, Ryuma Iwashita
  • Patent number: 10428140
    Abstract: It is intended to provide an anti-EphA4 antibody or an EphA4-binding fragment thereof which is capable of binding to EphA4 and inhibiting the binding between EphA4 and its ligand, and a pharmaceutical composition comprising the anti-EphA4 antibody or the EphA4-binding fragment thereof as an active ingredient. A mouse anti-EphA4 antibody having binding affinity for EphA4 was obtained, and the sequences of complementarity-determining regions (CDRs) of the mouse anti-EphA4 antibody were identified. This allowed for preparation of a humanized antibody comprising the CDR sequences of the mouse anti-EphA4 antibody in heavy chain variable region and light chain variable region.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: October 1, 2019
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Ryota Taguchi, Toshio Imai, Eiji Inoue, Akio Yamada, Aki Nakatani, Toshifumi Hirayama, Yuichi Ono, Shunsuke Ito
  • Publication number: 20190152306
    Abstract: In a back window part seal structure for a vehicle with a retractable roof wherein a weather strip is used, an outer panel 35 provided on a deck cover 18 includes an upper overlap portion 36 that covers a weather strip 40 at an upper edge of a back window 15 from diagonally above and behind the vehicle to improve the sealing property and achieve a configuration in which the assembly failure is less likely to occur.
    Type: Application
    Filed: February 27, 2017
    Publication date: May 23, 2019
    Applicant: WEBASTO JAPAN CO., LTD.
    Inventors: Koji SAWAHATA, Akio YAMADA, Yasufumi KAWAKAMI, Masaki ODA, Takashi SENOO, Miwa SHINOHARA, Keiichiro NISHIURA
  • Publication number: 20190118287
    Abstract: Provided is a three-dimensional laminating and shaping apparatus 100 including a column unit 200 that is configured to output an electron beam EB and deflect the electron beam EB toward the front surface of a powder layer 32, an insulating portion that electrically insulates a three-dimensional structure 36 from a ground potential member, an ammeter 73 that is configured to measure the current value indicative of the current flowing into the ground after passing through the three-dimensional structure 36, a melting judging unit 410 that is configured to detect that the powder layer 32 is melted based on the current value measured by the ammeter 73 and generate a melting signal, and a deflection controller 420 that is configured to receive the melting signal to determine the condition for the irradiation with the electron beam.
    Type: Application
    Filed: September 11, 2018
    Publication date: April 25, 2019
    Inventors: Shinji SUGATANI, Shigeki NISHINA, Jun MATSUMOTO, Masahiro TAKIZAWA, Minoru SOMA, Akio YAMADA
  • Publication number: 20190118286
    Abstract: Provided is a three-dimensional laminating and shaping apparatus 100 including a column unit 200 that is configured to output an electron beam EB and deflect the electron beam EB toward the front surface of a powder layer 32, an electron detector 72 that is configured to detect electrons that may be emitted in a predetermined direction from the front surface of the powder layer 32 when the powder layer 32 is irradiated with the electron beam EB, a melting judging unit 410 that is configured to generate a melting signal based on the strength of the detection signal from the electron detector 72, and a deflection controller 420 that is configured to receive the melting signal to determine the condition of the irradiation the electron beam.
    Type: Application
    Filed: September 4, 2018
    Publication date: April 25, 2019
    Inventors: Shinji SUGATANI, Shigeki NISHINA, Jun MATSUMOTO, Masahiro TAKIZAWA, Minoru SOMA, Akio YAMADA
  • Patent number: 10256074
    Abstract: To form a complex and fine pattern by combining optical exposure technology and charged particle beam exposure technology, provided is an exposure apparatus that radiates a charged particle beam at a position corresponding to a line pattern on a sample, including a beam generating section that generates a plurality of the charged particle beams at different irradiation positions in a width direction of the line pattern; a scanning control section that performs scanning with the irradiation positions of the charged particle beams along a longitudinal direction of the line pattern; a selecting section that selects at least one charged particle beam to irradiate the sample from among the plurality of charged particle beams, at a designated irradiation position in the longitudinal direction of the line pattern; and an irradiation control section that controls the at least one selected charged particle beam to irradiate the sample.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: April 9, 2019
    Assignee: INTEL CORPORATION
    Inventors: Akio Yamada, Shinji Sugatani, Masaki Kurokawa, Masahiro Seyama
  • Publication number: 20190077240
    Abstract: A weather strip 5 is attached to a peripheral edge of an opening 4a of a vehicle body 1?, and a deck cover 18 includes a resin outer panel 21 and an inner panel 23 joined onto a rear side of the outer panel 21. A spacer 35 is interposed between the outer panel 21 and the inner panel 23 such that a portion of the deck cover 18 provided with the spacer 35 makes contact with the weather strip 5 when the deck cover 18 is closed.
    Type: Application
    Filed: February 27, 2017
    Publication date: March 14, 2019
    Applicant: WEBASTO JAPAN CO., LTD.
    Inventors: Koji SAWAHATA, Akio YAMADA, Syuji YOSHIDA, Masato SHINKAWA, Takuya NISHIBAYASHI
  • Publication number: 20190077860
    Abstract: It is intended to provide an anti-EphA4 antibody or an EphA4-binding fragment thereof which is capable of binding to EphA4 and inhibiting the binding between EphA4 and its ligand, and a pharmaceutical composition comprising the anti-EphA4 antibody or the EphA4-binding fragment thereof as an active ingredient. A mouse anti-EphA4 antibody having binding affinity for EphA4 was obtained, and the sequences of complementarity-determining regions (CDRs) of the mouse anti-EphA4 antibody were identified. This allowed for preparation of a humanized antibody comprising the CDR sequences of the mouse anti-EphA4 antibody in heavy chain variable region and light chain variable region.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 14, 2019
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Ryota Taguchi, Toshio Imai, Eiji Inoue, Akio Yamada, Aki Nakatani, Toshifumi Hirayama, Yuichi Ono, Shunsuke Ito