Patents by Inventor Akira Hachiya

Akira Hachiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210128896
    Abstract: The present invention relates to a method for treating skin, comprising the following step A) and then step B): A) physically or chemically treating an epidermis of the skin; and B) forming a film containing a fiber deposit on the skin which has been subjected to the step A). When the above step B) is applied to the skin after the conventional step A), skin conditions such as inflammation, redness, and swelling caused by the step A) are alleviated, these conditions disappear more quickly, and the quality of life (QOL) of persons who have undergone the cosmetic or dermatological treatment is significantly improved.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 6, 2021
    Applicant: KAO CORPORATION
    Inventors: Akira HACHIYA, Sharon STRUEWING
  • Patent number: 10966911
    Abstract: To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 6, 2021
    Assignee: Kao Corporation
    Inventors: Daiki Murase, Akira Hachiya, Naoki Oya, Kei Takano, Akiko Kawasaki, Keigo Kawabata
  • Patent number: 10793854
    Abstract: Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: October 6, 2020
    Assignee: Kao Corporation
    Inventors: Daiki Murase, Akira Hachiya
  • Publication number: 20190053994
    Abstract: To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.
    Type: Application
    Filed: February 10, 2017
    Publication date: February 21, 2019
    Applicant: KAO CORPORATION
    Inventors: Daiki MURASE, Akira HACHIYA, Naoki OYA, Kei TAKANO, Akiko KAWASAKI, Keigo KAWABATA
  • Publication number: 20190015467
    Abstract: Provided is a material useful for preventing or ameliorating uneven skin tone, prevention or amelioration of uneven skin tone by enhancing autophagic activity, and a method for evaluating or selecting an agent for preventing or ameliorating uneven skin tone using an autophagic activity-enhancing action as an indicator.
    Type: Application
    Filed: July 9, 2018
    Publication date: January 17, 2019
    Applicant: KAO CORPORATION
    Inventors: Daiki MURASE, Ayumi Kusaka, Akira Hachiya, Asuka Imai
  • Publication number: 20180371524
    Abstract: Provided is a method by which a nucleic acid sample can be collected from a subject minimally invasively. A method for preparing a nucleic acid derived from a skin cell of a subject, comprising isolating the nucleic acid from skin surface lipids collected from the subject.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 27, 2018
    Applicant: KAO CORPORATION
    Inventors: Takayoshi INOUE, Akira Hachiya
  • Publication number: 20180325938
    Abstract: The present invention provides a method of identifying an agent which can rapidly and accurately regulate activity of androgen receptors in a sebaceous gland- and hair follicle-selective manner. A method of evaluating or selecting an androgen receptor activity regulator selective to sebaceous glands or hair follicles, the method comprising: (A) applying a test agent to cells from sebaceous glands or hair follicles under a hypoxic condition; (B) measuring HIF1? activity in the cells; (C) comparing the HIF1? activity measured in the (B) with HIF1? activity in a control group; and (D) determining a regulatory effect of the test agent on the HIF1? activity based on the result in the (C).
    Type: Application
    Filed: March 25, 2016
    Publication date: November 15, 2018
    Applicant: KAO CORPORATION
    Inventors: Takayoshi INOUE, Akira HACHIYA, Arisa KATO
  • Publication number: 20180051251
    Abstract: Cultured sebaceous gland cells capable of accumulating lipid droplets therein are provided. A method for producing mature human sebaceous gland cells, comprising culturing immature human sebaceous gland cells under hypoxic conditions.
    Type: Application
    Filed: February 8, 2016
    Publication date: February 22, 2018
    Applicant: KAO CORPORATION
    Inventors: Takayoshi INOUE, Akira HACHIYA
  • Publication number: 20170067054
    Abstract: Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Applicant: Kao Corporation
    Inventors: Daiki MURASE, Akira Hachiya
  • Patent number: 9561167
    Abstract: Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: February 7, 2017
    Assignee: Kao Corporation
    Inventors: Daiki Murase, Akira Hachiya
  • Patent number: 8927517
    Abstract: Use of autophagic activity in regulation of the amount of melanin in a keratinocyte, the control of skin or hair color, or selection of an agent for regulating the amount of melanin in a keratinocyte or an agent for controlling skin or hair color.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: January 6, 2015
    Assignee: Kao Corporation
    Inventors: Daiki Murase, Akira Hachiya
  • Patent number: 8871194
    Abstract: To provide a transformed hair follicle and a method for transferring a gene to a mammal by means of the transformed hair follicle. The invention provides a method for producing a transformed hair follicle including transferring a gene into a hair follicle by use of a virus vector, characterized by including providing a lentivirus pseudo-typed with VSV-G as a virus vector and transfecting a hair follicle with the lentivirus ex vivo.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: October 28, 2014
    Assignee: Kao Corporation
    Inventors: Akira Hachiya, Penkanok Sriwiriyanont
  • Patent number: 8771647
    Abstract: The present invention provides a human photoaged skin model and an animal model, and a method of making the same, for evaluating cosmetics and similar products in terms of their anti-aging or rejuvenating effect.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: July 8, 2014
    Assignee: Kao Corporation
    Inventors: Akira Hachiya, Tsutomu Fujimura
  • Publication number: 20130324587
    Abstract: Use of autophagic activity in regulation of the amount of melanin in a keratinocyte, the control of skin or hair color, or selection of an agent for regulating the amount of melanin in a keratinocyte or an agent for controlling skin or hair color.
    Type: Application
    Filed: April 8, 2013
    Publication date: December 5, 2013
    Inventors: Daiki MURASE, Akira HACHIYA
  • Publication number: 20130243713
    Abstract: Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
    Type: Application
    Filed: October 31, 2011
    Publication date: September 19, 2013
    Applicant: KAO CORPORATION
    Inventors: Daiki Murase, Akira Hachiya
  • Patent number: 8187841
    Abstract: A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that are capable of expressing TIMP-1 gene or TIMP-1 protein, with a test substance; (B) measuring the expression level of the TIMP-1 gene or the TIMP-1 protein in the cells; (C) comparing the expression level obtained in (B), with the expression level of TIMP-1 gene or TIMP-1 protein in a control group in which the cells capable of expressing TIMP-1 gene or TIMP-1 protein have not been contacted with the test substance; and (D) evaluating or selecting the test substance which increases the expression level of TIMP-1 gene or TIMP-1 protein, as an agent for preventing or curing photodamage of skin, based on the results of (C).
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: May 29, 2012
    Assignee: Kao Corporation
    Inventors: Urara Yokose, Akira Hachiya, Tsutomu Fujimura
  • Patent number: 8088570
    Abstract: There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16 genes or keratin 6 and/or keratin 16 proteins in a skin tissue or cell.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: January 3, 2012
    Assignee: Kao Corporation
    Inventors: Tsutomu Fujimura, Takuji Kume, Akira Hachiya
  • Patent number: 7973211
    Abstract: An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black person's skin is grafted onto a non-human animal, is provided.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: July 5, 2011
    Assignee: Kao Corporation
    Inventors: Akira Hachiya, Penkanok Sriwiriyanont, Shinya Kasamatsu
  • Patent number: 7897833
    Abstract: An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: March 1, 2011
    Assignee: Kao Corporation
    Inventors: Akira Hachiya, Penkanok Sriwiriyanont
  • Publication number: 20100323347
    Abstract: A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that are capable of expressing TIMP-1 gene or TIMP-1 protein, with a test substance; (B) measuring the expression level of the TIMP-1 gene or the TIMP-1 protein in the cells; (C) comparing the expression level obtained in (B), with the expression level of TIMP-1 gene or TIMP-1 protein in a control group in which the cells capable of expressing TIMP-1 gene or TIMP-1 protein have not been contacted with the test substance; and (D) evaluating or selecting the test substance which increases the expression level of TIMP-1 gene or TIMP-1 protein, as an agent for preventing or curing photodamage of skin, based on the results of (C).
    Type: Application
    Filed: June 18, 2009
    Publication date: December 23, 2010
    Applicant: Kao Corporation
    Inventors: Urara YOKOSE, Akira Hachiya, Tsutomu Fujimura