Abstract: In one non-limiting embodiment, the present disclosure is an antibody-containing formulation comprising an anti-IL-6 receptor antibody as an active ingredient, and contains histidine-aspartate buffer or histidine-glutamate buffer, Poloxamer 188, and arginine, and has a pH of 5.5 to 6.6. In one non-limiting embodiment, the present disclosure is a method of stabilizing an antibody-containing solution, a method of suppressing antibody association (e.g., dimerization), and a method of suppressing the generation of insoluble particles, wherein L-aspartic acid or L-glutamic acid, and optionally, Poloxamer 188 are added.

Abstract: A transmission device includes a casing accommodating a transmission gear and having an oil sump for retaining oil. The oil in the oil sump flows from a lubrication pump through a lubrication passage and is injected to the transmission gear. A connection portion is provided in a part of the lubrication passage, which part is disposed outside the casing. A direction control valve is provided downstream of the lubrication pump and upstream of the connection portion in the lubrication passage with respect to a flow direction of the oil. The direction control valve is configured to open the lubrication passage when a hydraulic pressure in the lubrication passage exceeds a predetermined value and to close the lubrication passage when the hydraulic pressure is equal to or lower than the predetermined value.

Abstract: A transmission device includes a casing accommodating a transmission gear and having an oil sump for retaining oil. The oil in the oil sump flows from a lubrication pump through a lubrication passage and is injected to the transmission gear. A connection portion is provided in a part of the lubrication passage, which part is disposed outside the casing. A direction control valve is provided downstream of the lubrication pump and upstream of the connection portion in the lubrication passage with respect to a flow direction of the oil. The direction control valve is configured to open the lubrication passage when a hydraulic pressure in the lubrication passage exceeds a predetermined value and to close the lubrication passage when the hydraulic pressure is equal to or lower than the predetermined value.

Abstract: A transmission structure of a helicopter according to one aspect is a transmission structure that transmits power from a prime mover to a rotary wing in the helicopter. The transmission structure includes: a housing; an input shaft that transmits the power of the prime mover to a gear arranged in the housing; a bearing supporting the input shaft in the housing such that the input shaft is rotatable, the bearing including an annular inner ring that holds the input shaft, an annular outer ring that is arranged outside the inner ring in a radial direction and fixed to the housing, and rolling elements sandwiched between the inner ring and the outer ring; and a sleeve that is sandwiched between an inner peripheral surface of the inner ring and the input shaft and is lower in heat conductivity than the inner ring and the input shaft.

Abstract: A transmission cooling assembly of a helicopter includes: a transmission including a speed change structure that changes the speed of rotation produced by rotational power input from a prime mover and outputs the resulting rotational power and a housing accommodating the speed change structure; a cowl covering at least a part of an outer surface of the housing, with a gap defined between the cowl and the outer surface; and a flow structure that allows external air to flow through the gap.

Abstract: A transmission lubricating assembly of a helicopter includes: a transmission including a speed change structure that changes the speed of rotation produced by rotational power input from a prime mover and outputs the resulting rotational power and a housing accommodating the speed change structure; and a lubricator that lubricates the speed change structure. The lubricator includes a collector that collects a mist of a lubricating oil in an internal space of the housing and a dropper that is disposed below the collector and that applies droplets of the lubricating oil to the speed change structure, the droplets resulting from the collected mist being gathered under its own weight.

Abstract: An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same. Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided. The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.

Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.

Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.

Abstract: A transmission device includes a casing accommodating a transmission gear and having an oil sump for retaining oil. The oil in the oil sump flows from a lubrication pump through a lubrication passage and is injected to the transmission gear. A connection portion is provided in a part of the lubrication passage, which part is disposed outside the casing. A direction control valve is provided downstream of the lubrication pump and upstream of the connection portion in the lubrication passage with respect to a flow direction of the oil. The direction control valve is configured to open the lubrication passage when a hydraulic pressure in the lubrication passage exceeds a predetermined value and to close the lubrication passage when the hydraulic pressure is equal to or lower than the predetermined value.

Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.

Abstract: The present invention provides stabilized preparations containing an antibody in a glycine buffer and/or a histidine buffer and also provides processes for preparing a protein-containing stabilized preparation, comprising adjusting the pH with a basic amino acid or a basic amino acid derivative or a salt thereof.

Abstract: The present inventors examined use of citric acid buffers for suppressing cryoprecipitation of IgM at a pH range and salt concentration suitable for storing IgM. As a result, the present inventors discovered that citric acid buffers significantly suppress cryoprecipitation.

Abstract: The present inventors examined use of citric acid buffers for suppressing cryoprecipitation of IgM at a pH range and salt concentration suitable for storing IgM. As a result, the present inventors discovered that citric acid buffers significantly suppress cryoprecipitation.

Abstract: The present invention provides stabilized preparations containing an antibody in a glycine buffer and/or a histidine buffer and also provides processes for preparing a protein-containing stabilized preparation, comprising adjusting the pH with a basic amino acid or a basic amino acid derivative or a salt thereof.

Abstract: A stabilized pharmaceutical preparation of an antibody to parathyroid hormone related peptide, wherein the antibody is dissolved in a buffer solution containing at least one buffer selected from the group consisting of acetic acid, citric acid, phosphoric acid, and salts thereof and is in the form of a solution of pH 5 to 8.