Patents by Inventor Akira Karasawa

Akira Karasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5270316
    Abstract: There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: December 14, 1993
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Takeshi Kuroda, Kazuhiro Kubo, Akira Karasawa, Tetsuji Ohno, Kenji Ohmori
  • Patent number: 5253007
    Abstract: A camera having a special photography function comprises a focus detecting circuit for detecting a state of focus of a subject, a focus-position altering circuit for altering a focus position of a photographic optical system in response to a detection result provided by the focus detecting circuit, and a special-photography executing circuit for executing special photography utilizing multiple exposure. The special-photography executing circuit is arranged to control the focus-position altering circuit in response to a release operation to shoot one exposure on a photosensitive portion with the photographic optical system placed in an in-focus position and continuously shoot at least one exposure on the same photosensitive portion with the photographic optical system placed in a defocused position on a closest-distance side, thereby effecting the multiple exposure.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: October 12, 1993
    Assignee: Canon Kabushiki Kaisha
    Inventors: Go Tokura, Akira Karasawa, Shoji Kaihara, Etsuro Furutsu, Nobuyuki Inoue
  • Patent number: 5242931
    Abstract: Novel Tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting act and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: September 7, 1993
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 5173492
    Abstract: There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula: ##STR1## wherein Y-Z represents ##STR2## R.sub.4 represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X.sup.2 represents oxygen, sulfur or NH; each of R.sup.1 and R.sup.2 independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R.sup.3 represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X.sup.1 represents oxygen or sulfur; and represents a single bond or a double bond or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: December 22, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Kenji Ohmori, Haruhiko Manabe, Kazuihiro Kubo, Akira Karasawa, Tetsuji Ohno, Shizuo Shiozaki, Akio Ishii, Katsuichi Shuto
  • Patent number: 5143922
    Abstract: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: November 20, 1990
    Date of Patent: September 1, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii, Hidee Ishii, Kenji Ohmori
  • Patent number: 5118701
    Abstract: Novel tricyclic compound represented by formula (I): ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: November 14, 1990
    Date of Patent: June 2, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 5068236
    Abstract: Novel xanthine compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have a diuretic action, a renal-protecting action and a vasodilative action.The compounds are useful as a diuretic, a renal-protecting agent and an antihypertensive agent.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: November 26, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Kazuhiro Kubo, Tetsuji Ohno, Akira Karasawa, Akio Ishii, Hiromi Nonaka
  • Patent number: 5010087
    Abstract: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: April 23, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 5010104
    Abstract: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: April 23, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 4999363
    Abstract: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: March 12, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 4994463
    Abstract: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: February 19, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii, Hidee Ishii, Kenji Ohmori
  • Patent number: 4971964
    Abstract: A pyridine derivative represented by formula (I): ##STR1## wherein the symbols are as defined in the specification, which exhibits selective, potential, and long-lasting inhibitory activity on biosynthesis of thromboxane A.sub.2 and is useful in the treatment and prevention of a broad range of diseases.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: November 20, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Koji Suzuki, Obase Hiroyuki, Akira Karasawa, Shiro Shirakura, Kubo Shizuoka, Ichiro Miki, Akio Ishii
  • Patent number: 4882351
    Abstract: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: November 21, 1989
    Assignee: Roussel Uclaf
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 4683220
    Abstract: Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: July 28, 1987
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Yamato, Hiroshi Kase, Isao Kawamoto, Masaji Kasai, Kunikatsu Shirahata, Takashi Deguchi, Katsuichi Shuto, Akira Karasawa, Ryo Okachi, Kiyoshi Nakayama
  • Patent number: 4677125
    Abstract: Phosphorus-containing oligopeptide derivatives are prepared by synthetic methods. The compounds exhibit angiotensin converting enzyme-inhibiting action and are, therefore, useful as anti-hypertensive agents.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 30, 1987
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Mitsuru Takahashi, Hisayo Nomoto, Hiroshi Kase, Katsuichi Shuto, Kazuhiro Kubo, Akira Karasawa
  • Patent number: 4501748
    Abstract: An optical isomer having an optical rotation degree of (+) from among (.+-.)-.alpha.-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dica rboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the hydrochloride of which has melting points ranging from 196.degree. to 202.degree. C.; or a salt thereof is described as being suitable for use in a pharmaceutical composition having hypotensive activity.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: February 26, 1985
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenji Muto, Akira Karasawa, Tokuyuki Kuroda, Nobuhiro Nakamizo