Patents by Inventor Akira Makino

Akira Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11970084
    Abstract: A vehicle drive device and a control method therefor are provided. The vehicle drive device includes: a power source including a first rotating electrical machine; a second rotating electrical machine; a differential unit including three rotating elements to which a first output shaft, a second output shaft, and the second rotating electrical machine are connected; and an electronic control device. The electronic control device regeneratively controls the first rotating electrical machine and the second rotating electrical machine in such a manner that negative torque is applied to the first output shaft and the second output shaft, when performing regenerative control by the second rotating electrical machine in a drive mode in which torque from the power source is distributed to the first output shaft and the second output shaft by controlling torque of the second rotating electrical machine during deceleration of a vehicle.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: April 30, 2024
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Atsushi Tabata, Koichi Okuda, Koji Takaira, Yuki Makino, Akinori Homan, Yosuke Akiyama, Akira Ijichi, Kunihiko Usui
  • Patent number: 11027026
    Abstract: To provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R0 represents any of a residue or a functional group derived from a cationic polymerization initiator; L represents a linker and L may not be present; n represents an integer of 1 or more; D represents a dye backbone of a dye having absorption in the near-infrared region.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: June 8, 2021
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hideo Saji, Kohei Sano, Akira Makino, Kengo Kanazaki, Fumio Yamauchi, Satoshi Ogawa
  • Patent number: 10828380
    Abstract: An object is to provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R represents any of a residue derived from a polymerization initiator, or a functional group; A may not be present, and when present, A represents any of a low-molecular compound, a dye, a reporter molecule, a target-binding molecule, a polymer or D; L represents a linker and L may not be present; n1 represents an integer of 1 or more; and D represents a dye backbone of a dye having absorption in the near-infrared region.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 10, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hideo Saji, Kohei Sano, Akira Makino, Kengo Kanazaki, Fumio Yamauchi, Satoshi Ogawa, Tatsuki Fukui
  • Publication number: 20190105412
    Abstract: The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect.
    Type: Application
    Filed: October 5, 2018
    Publication date: April 11, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Isao HARA, Ryo YAMAHARA, Eiichi OZEKI, Eri TAKEUCHI, Shunsaku KIMURA, Shinae KONDOH, Akira MAKINO, Fumihiko YAMAMOTO
  • Publication number: 20180280547
    Abstract: An object is to provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R represents any of a residue derived from a polymerization initiator, or a functional group; A may not be present, and when present, A represents any of a low-molecular compound, a dye, a reporter molecule, a target-binding molecule, a polymer or D; L represents a linker and L may not be present; n1 represents an integer of 1 or more; and D represents a dye backbone of a dye having absorption in the near-infrared region.
    Type: Application
    Filed: September 23, 2016
    Publication date: October 4, 2018
    Inventors: Hideo Saji, Kohei Sano, Akira Makino, Kengo Kanazaki, Fumio Yamauchi, Satoshi Ogawa, Tatsuki Fukui
  • Publication number: 20180228922
    Abstract: To provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R0 represents any of a residue or a functional group derived from a cationic polymerization initiator; L represents a linker and L may not be present; n represents an integer of 1 or more; D represents a dye backbone of a dye having absorption in the near-infrared region.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 16, 2018
    Inventors: Hideo Saji, Kohei Sano, Akira Makino, Kengo Kanazaki, Fumio Yamauchi, Satoshi Ogawa
  • Patent number: 9821078
    Abstract: Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.
    Type: Grant
    Filed: February 27, 2016
    Date of Patent: November 21, 2017
    Assignees: SHIMADZU CORPORATION, KYOTO UNIVERSITY
    Inventors: Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Patent number: 9623122
    Abstract: The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: April 18, 2017
    Assignees: SHIMADZU CORPORATION, KYOTO UNIVERSITY
    Inventors: Isao Hara, Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Publication number: 20160175464
    Abstract: Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.
    Type: Application
    Filed: February 27, 2016
    Publication date: June 23, 2016
    Inventors: Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Patent number: 9295734
    Abstract: Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: March 29, 2016
    Assignees: SHIMADZU CORPORATION, KYOTO UNIVERSITY
    Inventors: Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Publication number: 20150202327
    Abstract: The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span.
    Type: Application
    Filed: September 3, 2013
    Publication date: July 23, 2015
    Applicant: KYOTO UNIVERSITY
    Inventors: Isao Hara, Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Publication number: 20140127132
    Abstract: Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.
    Type: Application
    Filed: June 22, 2012
    Publication date: May 8, 2014
    Inventors: Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Publication number: 20110104056
    Abstract: The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect.
    Type: Application
    Filed: June 4, 2009
    Publication date: May 5, 2011
    Inventors: Isao Hara, Ryo Yamahara, Eiichi Ozeki, Eri Takeuchi, Shunsaku Kimura, Shinae Kondoh, Akira Makino, Fumihiko Yamamoto
  • Patent number: 4297106
    Abstract: In the measurement of iodine value by the Wijs method, the measurement can be effected rapidly by using magnesium acetate or sodium acetate as a catalyst.When the catalyst is used, the reaction time of a sample with a Wijs solution is as short as about 3 minutes. The time required for the measurement is thus reduced remarkably.
    Type: Grant
    Filed: August 1, 1980
    Date of Patent: October 27, 1981
    Assignee: The Nisshin Oil Mills, Ltd.
    Inventor: Akira Makino