Patents by Inventor Akira Nohara
Akira Nohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5204906Abstract: A noise-contained voice signal is cepstrum-analyzed to determine a peak and a mean-value thereof. When a peak is present, the signal is determined to be a vowel portion, and when a mean-value is large, the signal is determined to be a consonant portion, thereby allowing a voice portion to be accurately determined. Further, utilizing the detected result, noise is accurately canceled.Type: GrantFiled: January 3, 1991Date of Patent: April 20, 1993Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Akira Nohara, Joji Kane
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Patent number: 5195138Abstract: A cepstrum calculating device obtains a cepstrum of a voice signal and a mean-value calculation device cepstrum means output. A threshold setting device sets a voice detection threshold level on the basis of the cepstrum mean-value output. A cepstrum addition section adds a cepstrum value exceeding the cepstrum mean-value. A comparator compares the cepstrum output from the cepstrum addition section with the threshold output signal from the threshold setting device, thereby to output a voice-detection signal.Type: GrantFiled: January 3, 1991Date of Patent: March 16, 1993Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Joji Kane, Akira Nohara
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Patent number: 5148484Abstract: A signal processing unit separates voice signals and non-voice audio signals contained in a mixed audio signal. The mixed audio signal is channel divided, and the voice signal portions of the channel divided mixed audio signal are detected and extracted at one output. Non-voice audio signals contained in the voice signal portions are predicted based on the non-voice audio signal portions of the mixed audio signal. The thus predicted non-voice audio signals are combined with extracted non-voice audio signals to obtain continuous non-voice audio signals which are output at a second output. Alternately, instead of extracting the voice signals from the mixed audio signal, the predicted non-voice signals are removed from the mixed audio signal to obtain the voice signals which are output on the first output.Type: GrantFiled: May 15, 1991Date of Patent: September 15, 1992Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Joji Kane, Akira Nohara
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Patent number: 4769456Abstract: The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, methoxy or trifluormethyl, R.sup.2 and R.sup.3 are the same or different and are each hydrogen or methyl, R.sup.4 is a fluorinated lower alkyl having 2 to 5 carbon atoms and 1 to 11 fluorine atoms and X.sup.- is a pharmaceutically acceptable anion, respectively, possesses both strong antisecretory activity and gastric mucosal protective activity, which is produced by reacting a pyridine derivative of the formula ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the same meaning as defined above, with an acid.Type: GrantFiled: February 13, 1987Date of Patent: September 6, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4738975Abstract: The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, fluorine, methoxy or trifluoromethyl, R.sup.2 is a C.sub.1-8 alkyl, R.sup.3 is a C.sub.1-8 alkyl which may be fluorinated, and n is 0 or 1, or a pharmacologically acceptable salt thereof is useful for prevention and treatment of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.Type: GrantFiled: June 18, 1986Date of Patent: April 19, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4727150Abstract: The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, fluorine, methoxy or trifluoromethyl, R.sup.2 is hydrogen or methyl, R.sup.3 is a C.sub.3-8 straight-chain or branched alkyl, and n denotes 0 or 1, or their pharmacologically acceptable salts is novel and useful for prophylaxis and therapy of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.Type: GrantFiled: February 20, 1987Date of Patent: February 23, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4716167Abstract: The present invention relates to novel 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives useful for prophylaxis and therapy of allergic diseases such as allergic asthma, allergic dermatitis and hay fever, which have the following formula: ##STR1## wherein A is ##STR2## (R, R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl and m is 0 or 1, with the proviso that when m is 1, R.sup.1 is hydrogen) or R--Co-- (R has the same meaning as defined above), or a physiologically acceptable salt thereof, and to a method for preparing the same.Type: GrantFiled: January 28, 1986Date of Patent: December 29, 1987Assignee: Takeda Chemical Industries, Ltd.Inventor: Akira Nohara
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Patent number: 4714774Abstract: A benzoic acid derivative of the formula: ##STR1## wherein R.sup.1 stands for a lower alkyl group, R.sup.2 stands for an optionally protected carboxyl group and X stands for a halogen or a salt thereof, has excellent antiasthmatic and antiinflammatory activities and therefore is useful as an antiasthmatic or antiinflammatory agent for a mammalian animal.Type: GrantFiled: October 25, 1985Date of Patent: December 22, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4689333Abstract: The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, methoxy or trifluoromethyl, R.sup.2 and R.sup.3 are independently hydrogen or methyl, R.sup.4 is a C.sub.2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof is novel, and useful for prophylaxis and therapy of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.Type: GrantFiled: December 2, 1986Date of Patent: August 25, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4672073Abstract: A diphenoxypropane derivative of the formula: ##STR1## wherein X is a halogen atom, Y is a hydrogen atom or a hydroxy group and Z is a tetrazolyl or carboxy group, has excellent antiasthmatic and antiinflammatory activities, and therefore the diphenoxypropane derivatives are useful as antiasthmatic or antiiflammatory agents.Type: GrantFiled: November 5, 1985Date of Patent: June 9, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4628098Abstract: The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, methoxy or trifluoromethyl, R.sup.2 and R.sup.3 are independently hydrogen or methyl, R.sup.4 is a C.sub.2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof is novel, and useful for prophylaxis and therapy of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.Type: GrantFiled: July 29, 1985Date of Patent: December 9, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4567201Abstract: A diphenoxypropane derivative of the formula: ##STR1## wherein X is a halogen atom, Y is a hydrogen atom or a hydroxy group and Z is a tetrazolyl or carboxy group, has excellent antiasthmatic and antiinflammatory activities, and therefore the diphenoxypropane derivatives are useful as antiasthmatic or antiinflammatory agents.Type: GrantFiled: November 9, 1982Date of Patent: January 28, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Yoshitaka Maki
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Patent number: 4539326Abstract: The present invention relates to novel 5-oxo-5H-[1]benzopyrano[2,3-b]pyridine derivatives useful for effective medicines for the treatment of various connective tissue diseases such as chronic rheumatoid arthritis and varieties of inflammatory diseases caused by immunoreaction, which have the following formula: ##STR1## wherein R is the same or different and represents hydrogen, alkyl, alkoxy, nitro, hydroxyl, acyl, hydroxyalkyl, halogen with the proviso that m is 1,2 or 3, or a tetramethylene (--(CH.sub.2).sub.4 --) or butadienylene (--CH.dbd.CH--CH.dbd.CH--) group which, in conjunction with two adjacent carbon atoms on the ring, forms a six-membered ring with the proviso that m is 1; n is 1 or 2, or a physiologically acceptable salt or ester thereof.Type: GrantFiled: July 5, 1983Date of Patent: September 3, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Seiji Kuzuna
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Patent number: 4302463Abstract: Novel 1-azaxanthone-3-carboxylic acid derivatives, which are shown by the following formula (I) ##STR1## wherein R is hydrogen, alkyl, alkoxy or halogen; R.sub.1 and R.sub.2 are the same or different and each is hydrogen, alkyl or alkenyl; and m is 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases. The compound of the formula (I) can be produced by reacting a compound of the formula: ##STR2## wherein R and m have the same meaning as defined above; R.sub.3 is carboxyl or group which is convertible into carboxyl through hydrolysis; X is alkyl phosphate radical or halogen, with a compound of the formula: ##STR3## wherein R.sub.1 and R.sub.2 have the same meaning as defined above, or its salt, and conducting hydrolysis, if necessary.Type: GrantFiled: September 10, 1980Date of Patent: November 24, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Kiyoshi Ukawa, Akira Nohara
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Patent number: 4299963Abstract: The present invention relates to novel 1-azaxanthone-3-carboxylic acid and its derivatives usable for effective medicines for the treatment of allergic diseases, which are shown by the following formula (I) ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy or amino group which may be unsubstituted or substituted by one alkyl, m is 0, 1 or 2 and R.sub.2 is alkyl, alkoxy, halogen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl, and their physiologically acceptable salts.Type: GrantFiled: August 13, 1980Date of Patent: November 10, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Hirosada Sugihara, Kiyoshi Ukawa
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Patent number: 4267332Abstract: Novel 3-(tetrazol-5-yl)-1-azaxanthone and its derivatives, which are shown by the following formula ##STR1## wherein R.sub.1 is hydrogen, amino or hydroxyl; R.sub.2 is alkyl, alkoxy, halogen, nitro, carboxyl, hydroxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl; and m is 0, 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases.Type: GrantFiled: September 18, 1978Date of Patent: May 12, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Toshihiro Ishiguro, Kiyoshi Ukawa
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Patent number: 4255576Abstract: The present invention relates to novel 1-azaxanthone derivatives, which are shown by the following formula: ##STR1## wherein m is 1 or 2R'.sub.1 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxycarbonyl, hydroxy, C.sub.1-4 alkoxy, amino or C.sub.1-3 alkylamino;each of R.sub.2 is independently C.sub.1-6 alkyl, C.sub.1-4 alkoxy, halogen, nitro, hydroxy, carboxy, amino, C.sub.1-3 alkylamino or di(C.sub.1-3 alkyl) amino; orwhen m is 2, the two R.sub.2 groups may be independently as defined above or may form together with adjacent rings carbon atoms the butadienylene group;R.sub.3 is cyano, C.sub.1-6 alkoxycarbonyl, carboxamide, N-C.sub.1-3 alkylcarboxamide or N,N-di(C.sub.1-3 alkyl) carboxamide.The novel derivatives are useful as intermediates for 1-azaxanthone-3-carboxylic acid derivatives having effective antiallergic and bronchodilating activities.Type: GrantFiled: December 18, 1978Date of Patent: March 10, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Hirosada Sugihara, Kiyoshi Ukawa
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Patent number: 4232071Abstract: A method of roducing .gamma.-Fe.sub.2 O.sub.3 magnetic disk medium of continuous thin film is provided, in which a deposition source is deposited on an opposed Al-alloy substrate by means of a reactive vacuum deposition technique and the deposited film is thermally treated so as to be the magnetic disk medium. As the deposition source, a ferroalloy containing about 1 to 10 at.% Ti and about 0.5 to 5 at.% Co is employed.Type: GrantFiled: June 29, 1977Date of Patent: November 4, 1980Assignees: Nippon Telegraph and Telephone Public Corporation, Fujitsu LimitedInventors: Akira Terada, Seizi Hattori, Yoshikazu Ishii, Akira Nohara, Nobuo Inagaki, Wakatake Matsuda, Susumu Kawakami
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Patent number: 4151180Abstract: The present invention relates to novel chromone derivatives, which are shown by the following general formula ##STR1## wherein n is 0 or 1, m is 0, 1 or 2 when each of R's represents halogen, nitro, straight or branched alkyl having 1 to 6 carbon atoms, cyclic alkyl having 3 to 6 carbon atoms or butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any two adjacent carbon atoms at positions 5, 6, 7 and 8, --COOR', wherein R' is hydrogen, lower alkyl, aralkyl, carboxamide which may be unsubstituted or substituted by at least one lower alkyl or aralkyl, or amino group which may be unsubstituted or substituted by R'CO--, wherein R' is a straight or branched chain alkyl or aryl, or lower alkyl, aralkyl or aryl, m is 0 or 1 when each of R's represents hydroxy, lower alkoxy or R'COO--, wherein R' is a straight or branched chain alkyl or aryl. The novel derivatives are useful as intermediates for chromones having effective anti-allergic action.Type: GrantFiled: November 18, 1974Date of Patent: April 24, 1979Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Tomonobu Umetani, Yasushi Sanno
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Patent number: 4143042Abstract: The present invention relates to novel 1-azaxanthone-3-carboxylic acid and its derivatives usable for effective medicines for the treatment of allergic diseases, which are shown by the following formula (I) ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy or amino group which may be unsubstituted or substituted by one alkyl, m is 0, 1 or 2 and R.sub.2 is alkyl, alkoxy, halogen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl, and their physiologically acceptable salts.Type: GrantFiled: February 27, 1978Date of Patent: March 6, 1979Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Hirosada Sugihara, Kiyoshi Ukawa