Patents by Inventor Akira Noto

Akira Noto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determination of nagase and reagent therefor
    Patent number: 5155026
    Abstract: Highly sensitive reagent for colorimetrically determining N-acetyl-.beta.-D-glucosaminidase (NAGase) activity by the continuous method, comprising sodio-3,3'-dichlorophenolsulfonphthaleinyl N-acetyl-.beta.-D-glucosaminide and a buffer, with which renal dysfunction can be diagnosed precisely, quickly, and easily.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: October 13, 1992
    Assignee: Shionogi & Co., Ltd.
    Inventors: Akira Noto, Kunihiro Nakajima, Kazuyuki Sasakura, Tsutomu Sugasawa
  • Methods, hybridomas, monoclonal antibodies and sensitized cells for measuring HBS antigen
    Patent number: 5079173
    Abstract: This invention provides anti-HBs monoclonal antibodies HBs 8Cl, HBs 18E9 and HBs 22B7, an anti-human IgM monoclonal antibody HIgM 10C9 and an anti-mumps virus monoclonal antibody MPV 10G3 capable of inhibiting nonspecific reaction in the reverse passive agglutination, hybridomas producing them, a method for sensitizing fixed hemocytes with anti-HBs monoclonal antibodies, a fixed hemocyte sensitized with them by the said method, a method for inhibiting the said nonspecific reaction by utilizing the said monoclonal antibodies and an assay for HBs antigen by appropriately combining the above.
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: January 7, 1992
    Assignee: Shionogi & Co., Ltd.
    Inventors: Akira Noto, Akihiko Sato, Kunihiro Nakajima
  • Method for stabilizing rubella HA antigen
    Patent number: 4690819
    Abstract: A method for stabilizing rubella HA antigen which comprises adjusting a rubella HA antigen suspension at pH 9.6 or higher, and more preferably, concurrently adding sodium azide thereto, or adding sodium azide alone at a concentration of 1 to 10% (w/v) thereto without the above adjustment of pH.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: September 1, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Akihiko Sato, Akira Noto, Fumiaki Morita, Kunihiro Nakajima
  • N-Acetyl-.beta.-D-glucosaminides for determining N-acetyl-.beta.-D-glucosaminidase activity
    Patent number: 4552841
    Abstract: N-Acetyl-.beta.-D-glucosaminides produced from 1-chloro-1-deoxy-2,3,4,6-tetraacetyl-.alpha.-D-glucosamine and indicators for titration as the aglycons useful as substrates in kits for diagnostic aid, with which N-acetyl-.beta.-D-glucosaminidase activity can be determined colorimetrically in high sensitivity, precisely, and quickly.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: November 12, 1985
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasunao Ogawa, Akira Noto, Sachio Mori, Mitsuru Yoshioka
  • N-Acetyl-.beta.-D-glucosamnides for determining N-acetyl-.beta.-D-glucosaminidase activity
    Patent number: 4433139
    Abstract: N-Acetyl-.beta.-D-glucosaminides produced from 1-chloro-1-deoxy-2,3,4,6-tetraacetyl-.alpha.-D-glucosamine and indicators for titration as the aglycons useful as substrates in kits for diagnostic aid, with which N-acetyl-.beta.-D-glucosaminidase activity can be determined colorimetrically in high sensitivity, precisely, and quickly.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: February 21, 1984
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasunao Ogawa, Akira Noto, Sachio Mori, Mitsuru Yoshioka