Patents by Inventor Akira NUKAZUKA

Akira NUKAZUKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240353407
    Abstract: An analysis method for a target substance includes: mixing a conjugate and a sample including the target substance to produce a mixture, the conjugate including a labeled substance and a first binding substance having activity to bind to the target substance; bringing the mixture into contact with a second binding substance fixed to a base; and detecting a phenomenon caused by the labeled substance bound to the target substance that is bound to the second binding substance. The first binding substance is a substance including a nucleic acid, or a substance including an amino acid. The base is provided in each of regions. The target substance to which the second binding substance binds is different among the regions.
    Type: Application
    Filed: May 29, 2024
    Publication date: October 24, 2024
    Inventors: Kei HAYAKAWA, Mana ASANO, Akira NUKAZUKA, Kazuhisa NAKAGAWA, Mai NIIMOTO, Kazuhiko KANO
  • Publication number: 20240309439
    Abstract: An analysis method detects a target substance using a binding substance. The binding substance includes: a single-stranded nucleic acid preparation having activity to bind to the target substance; and a complementary nucleic acid that forms a base pair with a 3? terminal region of the single-stranded nucleic acid preparation when the single-stranded nucleic acid preparation is not bound to the target substance, and that dissociates from the 3? terminal region when the single-stranded nucleic acid preparation is bound to the target substance.
    Type: Application
    Filed: May 29, 2024
    Publication date: September 19, 2024
    Inventors: Mai NIIMOTO, Akira Nukazuka, Mana Asano, Kazuhisa Nakagawa, Kei Hayakawa
  • Publication number: 20240301476
    Abstract: An analysis method according to the present disclosure includes: mixing a binding substance and a sample including a target substance. The binding substance includes a nucleic acid region composed of a nucleic acid and having activity to bind to the target substance; removing the binding substance not bound to the target substance; amplifying the nucleic acid region; and detecting a phenomenon caused by the amplification of the nucleic acid region. For example, the analysis method includes: forming a complex of a template nucleic acid including a sequence complementary to a 3? side sequence of the nucleic acid region; and amplifying the nucleic acid region by an action of a nucleic acid amplifying enzyme using the complex as a starting point.
    Type: Application
    Filed: May 29, 2024
    Publication date: September 12, 2024
    Inventors: Akira NUKAZUKA, Teppei SAKAI, Mana ASANO, Kei HAYAKAWA, Kazuhisa NAKAGAWA, Mai NIIMOTO
  • Publication number: 20240241078
    Abstract: An ion sensor includes an ion detection element, a reference electrode that provides a reference point of a potential, and a solution in which an ion concentration can be changed in a sensing area of the ion detection element. The sensing area of the ion detection element is disposed in the solution. A method for detecting a target substance employs an ion sensor. The target substance bound to a label having a function of changing the amount of ions detectable by the ion sensor is introduced into the solution, and a change in the amount of ions is detected using the ion sensor.
    Type: Application
    Filed: March 13, 2024
    Publication date: July 18, 2024
    Inventors: Kazuhisa NAKAGAWA, Yuhei Shimizu, Daisuke Kobayashi, Masashi Suzuki, Akira Nukazuka, Teppei Sakai, Kei Hayakawa, Kazuhiko Kano, Mana Asano
  • Publication number: 20230258549
    Abstract: An object identification method capable of quickly and accurately identifying a virus or the like is provided. An object identification method according to an aspect of the present disclosure includes feeding an object dispersed in a solvent to a micro-channel, and applying an AC (Alternating Current) voltage to a measurement electrode provided at the micro-channel and measuring an AC characteristic of the object when the object passes through the micro-channel. Then, a combined impedance and a phase are determined by using the measured AC characteristic, and the object is identified by using the determined combined impedance and the phase.
    Type: Application
    Filed: January 4, 2023
    Publication date: August 17, 2023
    Inventors: Takatoki YAMAMOTO, Akira NUKAZUKA, Kei HAYAKAWA, Kazuhiko KANO
  • Patent number: 11485877
    Abstract: A structure body includes a base material and a siloxane based molecular membrane formed on the base material by use of an organic compound represented by Formula (1) or Formula (2): wherein any one of R1 to R5 is an amino group, others of R1 to R5 are each independently hydrogen or an alkyl group, R7 to R9 are each independently any one of hydroxy group, alkoxy group, alkyl group, and phenyl group on condition that one or more of R7 to R9 are each independently a hydroxy group or an alkoxy group, and R6 is an alkyl group.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: November 1, 2022
    Assignee: DENSO CORPORATION
    Inventors: Kei Hayakawa, Hajime Shingai, Akira Nukazuka, Hitoshi Kuno
  • Publication number: 20220334107
    Abstract: A method for detecting a plurality of target substances using a plurality of conjugates each including a binding substance and a label is provided. The binding substance has an activity to bind to one of the target substances and the label causes a detectable phenomenon. The method includes binding at least some of the plurality of conjugates with the plurality of target substances, removing a remainder of the plurality of conjugates that is not bound to the plurality of target substances, and detecting the label. A molecular weight of the binding substance is less than a molecular weight of an immunoglobulin.
    Type: Application
    Filed: April 15, 2022
    Publication date: October 20, 2022
    Inventors: Akira NUKAZUKA, Mana ASANO, Kei HAYAKAWA, Kazuhiko KANO, Kazuhisa NAKAGAWA, Mai NIIMOTO
  • Publication number: 20220334106
    Abstract: A conjugate includes a binding substance having an activity to bind to a target substance and a label causing a detectable phenomenon. A molecular weight of the binding substance is less than a molecular weight of an immunoglobulin.
    Type: Application
    Filed: April 15, 2022
    Publication date: October 20, 2022
    Inventors: Akira NUKAZUKA, Mana ASANO, Kei HAYAKAWA, Yuuya YOSHIMITSU, Kazuhiko KANO, Kazuhisa NAKAGAWA, Mai NIIMOTO
  • Publication number: 20210396744
    Abstract: A complex includes photoresponsive liposomes, a first buffer solution, and a second buffer solution. Each of the photoresponsive liposomes includes a membrane that contains azobenzene compound and phospholipid and a membrane binding site that is immobilized to the membrane and bindable to a target substance. The first buffer solution is filled inside the photoresponsive liposomes. The second buffer solution exists outside of the photoresponsive liposomes. The first buffer solution has a composition that is different from that of the second buffer solution.
    Type: Application
    Filed: August 30, 2021
    Publication date: December 23, 2021
    Inventors: Akira NUKAZUKA, Hitoshi KUNO, Tsutomu HAMADA, Katsunori KOUDA, Taira KOBAYASHI
  • Publication number: 20210017420
    Abstract: A structure body includes a base material and a siloxane based molecular membrane formed on the base material by use of an organic compound represented by Formula (1) or Formula (2): wherein any one of R1 to R5 is an amino group, others of R1 to R5 are each independently hydrogen or an alkyl group, R7 to R9 are each independently any one of hydroxy group, alkoxy group, alkyl group, and phenyl group on condition that one or more of R7 to R9 are each independently a hydroxy group or an alkoxy group, and R6 is an alkyl group.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 21, 2021
    Inventors: Kei HAYAKAWA, Hajime SHINGAI, Akira NUKAZUKA, Hitoshi KUNO