Patents by Inventor Akira Ohtori
Akira Ohtori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8697751Abstract: An object of the present invention is to provide a stable aqueous pharmaceutical composition which suppresses degradation of prostaglandin F2? in a preparation containing prostaglandin F2?. The object was attained by formulating a prostaglandin F2? derivative into an oil-in-water emulsion together with an oil, for example, medium chain fatty acid triglyceride, a water-soluble polymer and water.Type: GrantFiled: August 10, 2011Date of Patent: April 15, 2014Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Yusuke Sakai, Akira Ohtori
-
Patent number: 8101654Abstract: The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises olopatadine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising olopatadine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby casing transfer of a therapeutically effective amount of olopatadine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.Type: GrantFiled: July 7, 2006Date of Patent: January 24, 2012Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Akiharu Isowaki, Tomoko Nakajima, Akira Ohtori
-
Publication number: 20110294880Abstract: An object of the present invention is to provide a stable aqueous pharmaceutical composition which suppresses degradation of prostaglandin F2? in a preparation containing prostaglandin F2?. The object was attained by formulating a prostaglandin F2? derivative into an oil-in-water emulsion together with an oil, for example, medium chain fatty acid triglyceride, a water-soluble polymer and water.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Applicant: SENJU PHARMACEUTICAL CO., LTD.Inventors: Yusuke SAKAI, Akira Ohtori
-
Publication number: 20100150992Abstract: A transdermal drug delivery system for treatment of ophthalmic diseases comprising a structure that a plaster layer containing a remedy for ophthalmic diseases is provided on a support, wherein the system is applied to a skin surface including a front surface of an eyelid to administer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow. Use of the transdermal drug delivery system for treatment of ophthalmic diseases, comprising applying the transdermal drug delivery system to a skin surface including a front surface of an eyelid to transfer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow, and a method for transferring the remedy for ophthalmic diseases to the ophthalmic topical tissue.Type: ApplicationFiled: February 25, 2010Publication date: June 17, 2010Inventors: Kohji Kawahara, Yasuhiko Aramomi, Akira Ohtori, Akiharu Isowaki
-
Publication number: 20090318422Abstract: The present invention provides an ophthalmic percutaneous absorption type preparation containing an ophthalmic drug and a vasoconstrictor, which can increase the amount of the ophthalmic drug transferred through the eyelid to a topical area in the eye, particularly the anterior segment of the eye such as conjunctiva, lacrimal fluid, aqueous humor, cornea and the like by administration to the skin surface of an eyelid.Type: ApplicationFiled: August 28, 2007Publication date: December 24, 2009Inventors: Akiharu Isowaki, Tomoko Nakajima, Akira Ohtori
-
Publication number: 20090220580Abstract: The present invention provides a percutaneous absorption formulation including a patch having an adhesive layer disposed on a substrate and the adhesive layer contains ketotifen fumarate and tris(hydroxymethyl)aminomethane, and the patch is packaged in a hygroscopic packaging material. In the percutaneous absorption formulation, tris(hydroxymethyl)aminomethane particularly selected from various basic substances is incorporated, and by packaging the patch in a hygroscopic packaging material, the percutaneous absorptivity and content stability of a drug can be simultaneously improved and the yellowing of the drug can be suppressed. These effects can be further improved by the incorporation of propyl gallate, the use of an adhesive layer including an SIS-based adhesive base and a rosin ester-based adhesion imparting resin, and/or the removal of oxygen from the atmosphere in the inside of the packaging material.Type: ApplicationFiled: April 20, 2005Publication date: September 3, 2009Applicant: SENJU PHARMACEUTICAL CO., LTD.Inventors: Kouji Kawahara, Yasuhiko Aramomi, Noriko Shimada, Akira Ohtori, Akiharu Isowaki
-
Publication number: 20090209632Abstract: The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises olopatadine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising olopatadine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby casing transfer of a therapeutically effective amount of olopatadine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.Type: ApplicationFiled: July 7, 2006Publication date: August 20, 2009Inventors: Akiharu Isowaki, Tomoko Nakajima, Akira Ohtori
-
Publication number: 20090143359Abstract: The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises epinastine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising epinastine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby causing transfer of a therapeutically effective amount of epinastine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.Type: ApplicationFiled: July 7, 2006Publication date: June 4, 2009Inventors: Akiharu Isowaki, Tomoko Nakajima, Akira Ohtori
-
Publication number: 20090082381Abstract: The present invention provides a percutaneously absorbable ophthalmic preparation that permits the retention of a therapeutically effective concentration of a heterocyclic spiro compound and a salt thereof for promoting lacrimation, and that produces less adverse reactions such as miosis. Specifically, the present invention provides a percutaneously absorbable ophthalmic preparation comprising as an active ingredient a heterocyclic spiro compound represented by the general formula (I): [wherein the symbols have the same definitions as those given in the description] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 26, 2006Publication date: March 26, 2009Inventors: Akiharu Isowaki, Akira Ohtori
-
Publication number: 20080139652Abstract: An object of the present invention is to provide a stable aqueous pharmaceutical composition which suppresses degradation of prostaglandin F2? in a preparation containing prostaglandin F2?. The object was attained by formulating a prostaglandin F2? derivative into an oil-in-water emulsion together with an oil, for example, medium chain fatty acid triglyceride, a water-soluble polymer and water.Type: ApplicationFiled: October 26, 2004Publication date: June 12, 2008Inventors: Yusuke Sakai, Akira Ohtori
-
Publication number: 20070053964Abstract: A percutaneous absorption type ophthalmic preparation comprising muscarinic receptor agonist is prepared, which can promote lacrimal fluid secretion by administration to the skin surface of the eyelid, and which causes fewer side effects such as miosis, thereby to provide a percutaneous absorption type ophthalmic preparation capable of maintaining a therapeutically effective concentration of a muscarinic receptor agonist for promoting lacrimal fluid secretion, which is associated with fewer side effects such as miosis, and a method of promoting lacrimal fluid secretion by administering a percutaneous absorption type ophthalmic preparation containing a muscarinic receptor agonist to the skin surface of the eyelid.Type: ApplicationFiled: May 20, 2005Publication date: March 8, 2007Inventors: Akiharu Isowaki, Akira Ohtori
-
Publication number: 20060036220Abstract: A transdermal drug delivery system for treatment of ophthalmic diseases comprising a structure that a plaster layer containing a remedy for ophthalmic diseases is provided on a support, wherein the system is applied to a skin surface including a front surface of an eyelid to administer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow. Use of the transdermal drug delivery system for treatment of ophthalmic diseases, comprising applying the transdermal drug delivery system to a skin surface including a front surface of an eyelid to transfer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow, and a method for transferring the remedy for ophthalmic diseases to the ophthalmic topical tissue.Type: ApplicationFiled: January 22, 2004Publication date: February 16, 2006Inventors: Kohji Kawahara, Yasuhiko Aramomi, Akira Ohtori, Akiharu Isowaki
-
Patent number: 6645963Abstract: Eye drops containing a &bgr;-blocker such as cartelol hydrochloride are improved in the penetration of the &bgr;-blocker into the eye and the retention thereof in the eye tissues by the incorporation of a C3-7 fatty acid such as sorbic acid to the eye preparations.Type: GrantFiled: March 12, 2001Date of Patent: November 11, 2003Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Masayo Higashiyama, Akira Ohtori
-
Patent number: 6335335Abstract: Eye drops containing a &bgr;-blocker such as cartelol hydrochloride are improved in the penetration of the &bgr;-blocker into the eye and the retention thereof in the eye tissues by the incorporation of a C3-7 fatty acid such as sorbic acid to the eye preparations.Type: GrantFiled: March 12, 2001Date of Patent: January 1, 2002Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Masayo Higashiyama, Akira Ohtori
-
Publication number: 20010041721Abstract: Eye drops containing a &bgr;-blocker such as cartelol hydrochloride are improved in the penetration of the &bgr;-blocker into the eye and the retention thereof in the eye tissues by the incorporation of a C3-7 fatty acid such as sorbic acid to the eye preparations.Type: ApplicationFiled: March 12, 2001Publication date: November 15, 2001Inventors: Masayo Higashiyama, Akira Ohtori
-
Publication number: 20010012859Abstract: Eye drops containing a &bgr;-blocker such as cartelol hydrochloride are improved in the penetration of the &bgr;-blocker into the eye and the retention thereof in the eye tissues by the incorporation of a C3-7 fatty acid such as sorbic acid to the eye preparations.Type: ApplicationFiled: March 12, 2001Publication date: August 9, 2001Inventors: Masayo Higashiyama, Akira Ohtori
-
Patent number: 5501856Abstract: Presented are a controlled-release pharmaceutical preparation for intra-ocular implant to be applied to the interior of the eye after a surgical operation for disorders in retina/vitreous body or for glaucoma, which is produced by homogeneously dispersing an anti-inflammatory agent or a cell proliferation antagonist in certain polylactic acid and forming it into a particular shape; and a method for the prevention of the recurrence of said disorders or glaucoma after a surgical operation therefor.Type: GrantFiled: November 27, 1991Date of Patent: March 26, 1996Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Akira Ohtori, Masako Andoh, Yasushi Morita
-
Patent number: 5183662Abstract: The present invention is concerned with a controlled drug release composition comprising a poorly soluble drug, a water-soluble macromolecular compound and biodegradable macromolecular compound, which composition can be freely tailored to the required solubility and release pattern of the poorly soluble drug through adjustment of the ratio of said ingredients.Type: GrantFiled: August 27, 1991Date of Patent: February 2, 1993Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Yasushi Morita, Akira Ohtori, Masako Andoh
-
Patent number: 5152758Abstract: An electroresponsive hydrogel produced by alkali hydrolysis of a copolymer comprising N-isopropylacrylamide, an ionic monomer and a crosslinking agent; and a physiologically active substance release control system comprising a biosensor, an amplifier and an electroresponsive hydrogel containing physiologically active substance are disclosed. The hydrogel of the present invention is capable of releasing a physiologically active substance alone in an amount corresponding to the applied voltage with excellent reproducibility by contracting and reswelling in good response to the loading and unloading of an external stimulation voltage, it can be advantageously used in a physiologically active substance release control system capable of releasing an essential physiologically active substance in a necessary amount according to changes in physiological conditions.Type: GrantFiled: July 23, 1990Date of Patent: October 6, 1992Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Isao Kaetsu, Yasushi Morita, Akira Ohtori
-
Patent number: 4910225Abstract: This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient.An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type.The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.Type: GrantFiled: January 24, 1989Date of Patent: March 20, 1990Assignees: Senju Pharmaceutical Co., Ltd., A. H. Robins Company, IncorporatedInventors: Takahiro Ogawa, Yoshikazu Kuribayashi, Kazumichi Ushio, Akira Ohtori