Patents by Inventor Akira Okamachi

Akira Okamachi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronic acid-methotrexate conjugate
    Patent number: 8088916
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: January 3, 2012
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
  • Hyaluronic acid-methotrexate conjugate
    Patent number: 7807675
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 5, 2010
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
  • Hyaluronic Acid-Methotrexate Conjugate
    Publication number: 20090093414
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
    Type: Application
    Filed: April 1, 2005
    Publication date: April 9, 2009
    Applicant: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
  • Hyaluronic Acid-Methotrexate Conjugate
    Publication number: 20070197465
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
    Type: Application
    Filed: March 4, 2005
    Publication date: August 23, 2007
    Applicants: Denki Kagaku Kabushiki Kaisha, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
  • Fluoroquinoline derivative
    Patent number: 5776948
    Abstract: Antibacterial fluoroquinoline derivatives and salts thereof of the following formula are stable and have low toxicity and high photostability and low cytotoxicity under light irradiation: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl;R.sub.2 is hydrogen, optionally protected amino, optionally protected aminocarbonyl or optionally protected carboxyl;R.sub.5 is halogen, lower alkyl or optionally protected hydroxyl or is the same as R.sub.2 ;R.sub.6 is lower alkyl;A is CH.sub.2, optionally protected nitrogen or oxygen;andn and m are each an integer of from 0 to 4, provided that n +m is an integer of from 1 to 4.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: July 7, 1998
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takeshi Yokota, Masayuki Haramura, Akira Okamachi, Toshihiko Makino