Abstract: An instrument management device includes a memory and a processor to execute a program stored in the memory to perform display processing, acquisition processing, and counting processing. In the display processing, in reissuing a sterilization label that is issued when sterilization processing is performed on an instrument set including medical instruments, a reissuance reason registration screen including a reason specifying area via which an operator specifies a type of reissuance reason is displayed on a display device. In the acquisition processing, the type of reissuance reason specified in the reason specifying area is acquired and stored in the memory. In the counting processing, for each type of reissuance reason stored in the memory, a number of times the sterilization label has been reissued for a reason of the type of reissuance reason is counted.

Abstract: A storage management device stores sterilization information in which a sterilization ID of an instrument set and a rack ID of a rack number of a rack are associated with one another. A target rack ID assigned to the rack number of the rack in which the instrument set is stored is acquired. A target sterilization ID of the instrument set that is stored is acquired. The rack ID associated with the sterilization ID that matches the target sterilization ID is extracted from the sterilization information and the rack ID is determined as an extracted rack ID. Whether the extracted rack ID matches the target rack ID is determined. When the extracted rack ID does not match the target rack ID, a wrong rack is notified.

Abstract: A memory of a storage management device stores storage history information in which at least a storage ID of an instrument set including one or more medical instruments is stored and a sterilization ID indicating that sterilization processing has been performed on the instrument set are associated with one another. A processor executes sterilization ID acquisition processing to acquire a target sterilization ID of an instrument set that is a target to be stocked, determination processing to determine whether the sterilization ID that matches the target sterilization ID is included in the storage history information, and notification processing to notify, when it is determined in the determination processing that the sterilization ID that matches the target sterilization ID is included in the storage history information, that the instrument set having the target sterilization ID has been re-stocked.

Abstract: An alert notification device of a dental processing machine includes a receiver, a first extractor, and a notifier. The receiver receives error information from the dental processing machine. The first extractor extracts from the error information received by the receiver, as first extracted error information, error information that occurred in a predetermined first time. The notifier notifies a management device to be used by a maintenance company to perform maintenance of the dental processing machine, of an alert concerning the first extracted error information.

Abstract: The present invention provides peptides containing the BIG3 polypeptide-binding site in a PHB2 polypeptide, which inhibit the binding between a PHB2 polypeptide and a BIG3 polypeptide, and pharmaceutical compositions containing the peptide. The peptides of the present invention have the ability to bind not to PHB2, whose expression is found in organs throughout the human body, but to BIG3, which is a protein highly expressed specifically in particularly estrogen receptor-positive cancer, and have excellent growth suppressive effects on BIG3-positive cancer cells. Accordingly, the peptides of the present invention are useful as therapeutic agents for breast cancer which can avoid expression of side effects.

Abstract: An object of the present invention is to provide a method for producing a peptide thioester compound, a peptide hydrazide compound, and a peptide amide compound. The present invention provides a method for producing a peptide hydrazide compound or a peptide amide compound by using a compound represented by Formula (2): wherein R1, R2, R3, and X are as defined in the specification, and using a hydrazine compound or an ammonia compound as a reaction reagent. The present invention also provides a method for producing a peptide thioester compound from the peptide hydrazide compound.

Abstract: An object of the present invention is to provide a method for producing a peptide thioester compound, a peptide hydrazide compound, and a peptide amide compound. The present invention provides a method for producing a peptide hydrazide compound or a peptide amide compound by using a compound represented by Formula (2): wherein R1, R2, R3, and X are as defined in the specification, and using a hydrazine compound or an ammonia compound as a reaction reagent. The present invention also provides a method for producing a peptide thioester compound from the peptide hydrazide compound.

Abstract: The objective of the present invention is to provide a new compound which is effective in treating blood cancer, particularly multiple myeloma, and which is also effective in suppressing an SP cell, i.e. Side Population Cell, which is a cause of recurrence of cancer. The compound according to the present invention is a novel compound which has the specific benzylamine structure.

Abstract: Peptidic compounds which significantly reduce serum phosphate levels and which, in addition, reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with elevated serum phosphate levels by administering the peptidic compounds by oral or injectable means.

Abstract: Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.

Abstract: Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.