Abstract: It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. The present invention provides a conjugate of a compound represented by the following formula (1) or a salt thereof and a phthalocyanine dye: wherein the meaning of each of symbols is as defined in the specification.

Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, angsd usage of them.

Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, angsd usage of them.

Abstract: An object of the present invention is to provide a halogenated biotin-modified dimer, which is capable of imaging diagnosis or treatment by labeling with a halogen, a biotin-modified dimer having a high affinity for a mutant streptavidin with a low affinity for natural biotin. The present invention provides a compound represented by the following formula (1) or a salt thereof: wherein the meaning of each symbol is the same as that described in the specification.

Abstract: Disclosed herein is a sheet-binding apparatus. The apparatus has two sheet binding units, each configured to bind the sheets manually inserted from outside. The sheet binding units operate independently, each at the timing appropriate for a specific need.

Abstract: According to the present invention, it is provided a shaping method including a formation step of forming a powder layer using a first powder, an arrangement step of arranging a second powder having an average particle diameter smaller than that of the first powder in a partial region of the powder layer, and a first heating step of heating the powder layer on which the second powder has been arranged at a temperature at which particles contained in the second powder are sintered or melted. When a compressive strength of the powder layer in the partial region after the first heating step is denoted by P1 and a compressive strength of the first powder outside the partial region is denoted by P2, a relationship of P1?0.5 MPa>P2 is established.

Abstract: A shaping plate to be set on a shaping stage of a shaping system for performing shaping by an additive manufacturing method includes a water-insoluble base substrate and an underlying layer containing a water-soluble material on at least one surface of the base substrate, wherein the base substrate has a plurality of through holes that extend in the direction intersecting the surface provided with the underlying layer.

Abstract: A bis-iminobiotin compound which has a structure that enables the easy bonding of a bis-iminobiotin moiety to a drug or a fluorescent compound and is useful for the delivery of a drug to a streptavidin-labeled substance. The bis-iminobiotin compound is represented by general formula 9. In the formula, A, D and E independently represent a spacer capable of bonding two bicyclo rings to each other, wherein E represents a structure that may be branched, each of A, D and E may have a substituent, and A, D and E may together form a cyclic structure; J represents a functional group for achieving a click reaction; G represents a spacer capable of bonding E to J; and R represents a hydrogen atom, an acetyl group, a benzyl group, a trifluoroacetyl group or a Boc group.

Abstract: A powder contains particles containing a water-soluble material and a water-insoluble material. When dependence on temperature of a storage elastic modulus and a loss elastic modulus of a cylindrical compact of the powder in a shear direction, the cylindrical compact having a diameter of 10 mm and a thickness of 1 mm, is measured with a rotational rheometer at an angular frequency of 1 Hz and a rate of temperature increase of 2° C./min, letting a temperature at which the storage elastic modulus is 1 MPa be T° C., the storage elastic modulus is always higher than the loss elastic modulus in a temperature range of T° C. to (T+10)° C.

Abstract: A method of producing a three-dimensional shaped article includes a step of forming particle layers by arranging particles containing a material for forming a shaped article and particles containing a material having higher solubility in fluid than the material for forming the shaped article, a step of forming a stack by melting and stacking the particle layers, and a step of removing the material having higher solubility in the fluid than the material for forming the shaped article from the stack by dissolving the material having higher solubility in the fluid than the material for forming the shaped article in the fluid.

Abstract: A three-dimensional object is obtained by repeating multiple times forming a ceramic powder layer formed of a ceramic powder and applying to a desired region of the ceramic powder layer a liquid precursor composition at least containing at least any one of a metal alkoxide, a metal chloride, a hydrolysate of the metal alkoxide and a polycondensate of the hydrolysate, and water, thereby obtaining a laminated body; subsequently heating the laminated body at a temperature lower than the sintering temperature of the ceramic powder; and removing the ceramic particle in a region to which the precursor composition has not been applied.

Abstract: An object shaping method includes a step of forming a powder layer using first powder, a step of placing second powder having an average particle diameter smaller than an average particle diameter of the first powder at a part of a region of the powder layer, and a first heating step of heating the powder layer in which the second powder is placed. The average particle diameter is equal to or larger than 1 nm and equal to or smaller than 500 nm, and the first heating step performs heating the powder layer at a temperature at which particles contained in the second powder are sintered or melted.

Abstract: An image forming apparatus includes a photoconductor unit that supports a photoconductor drum, a transfer roller brought into pressure contact with the photoconductor drum, a transfer unit that supports the transfer roller, a sheet guide provided between the photoconductor unit and the fixing unit, and a support holder that supports the transfer unit and the sheet guide. The support holder moves to bring the transfer unit and the sheet guide into and out of contact with the photoconductor unit and the fixing unit. The transfer unit is provided with a transfer positioning section that positions the transfer unit by coming into abutment therewith. The sheet guide is provided with a guide positioning section that positions the sheet guide by coming into abutment therewith. The transfer unit and the sheet guide are joined to each other by an engagement unit that engages the two with each other.

Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, angsd usage of them.

Abstract: Provided is a method of producing a three-dimensional object, including: a first step of placing and laminating a water-insoluble structural material and a support material each containing a water-soluble material and a fiber material to form a material layer; and a second step of bringing a portion of the shaped object including the support material into contact with a liquid containing water and a bipolar surfactant to remove the portion.

Abstract: To allow easy access to a jammed sheet when a sheet jam occurs in a sheet processing device installed inside the body of an image forming apparatus. An image forming apparatus is provided with a sheet binding unit that applies binding to sheets. The sheet binding unit has a carry-in port for receiving a sheet to be conveyed to a sheet carry-in path formed thereinside and an openable cover for opening the carry-in port. The end portion of the openable cover on the carry-in port side and an end portion of an operation part for inputting an operational item for the operation carried out in the image forming apparatus are arranged spaced apart from each other at a predetermined distance.

Abstract: A method of producing a three-dimensional shaped article includes a step of forming particle layers by arranging particles containing a material for forming a shaped article and particles containing a material having higher solubility in fluid than the material for forming the shaped article, a step of forming a stack by melting and stacking the particle layers, and a step of removing the material having higher solubility in the fluid than the material for forming the shaped article from the stack by dissolving the material having higher solubility in the fluid than the material for forming the shaped article in the fluid.

Abstract: Disclosed herein is a sheet-binding apparatus. The apparatus has two sheet binding units, each configured to bind the sheets manually inserted from outside. The sheet binding units operate independently, each at the timing appropriate for a specific need.

Abstract: To allow easy access to a jammed sheet when a sheet jam occurs in a sheet processing device installed inside the body of an image forming apparatus. An image forming apparatus is provided with a sheet binding unit that applies binding to sheets. The sheet binding unit has a carry-in port for receiving a sheet to be conveyed to a sheet carry-in path formed thereinside and an openable cover for opening the carry-in port. The end portion of the openable cover on the carry-in port side and an end portion of an operation part for inputting an operational item for the operation carried out in the image forming apparatus are arranged spaced apart from each other at a predetermined distance.

Abstract: Provided are constituent particles containing a water-soluble material with high flowability in the form of powder, the constituent particles being capable of forming a support member that can be removed with a water-containing solvent in a process for producing a three-dimensional object. The constituent particles used for the production of a three-dimensional object each include a core and a shell that covers at least part of a surface of the core, the core containing a water-soluble material most abundantly, and a material contained in the shell most abundantly having a lower water solubility than the water-soluble material contained in the core.