Abstract: A medicine administering device for nasal cavities, comprising a capsule holding section formed with a capsule containing powder-state medicine. An air supply section is connected to the lower end of the capsule holding section and formed with an air supply passage which is in communication with the capsule accommodating chamber. A branched passage section is connected to the upper end of the capsule holding section and has an air flow passage in communication with the capsule accommodating chamber. The air flow passage is bifurcated to form first and second outlet passage portions which are arranged to form a generally Y-shape. First and second medicine passages are formed such that air from the branched passage section flows therethrough to carry the medicine in the capsule into right-side and left-side nasal cavities of a patient. The first and second passages are respectively in communication with the first and second outlet passages of the branched passage section.

Abstract: A capsule holder 2 of a medicine administering device 1 for nasal cavities comprises a movable member 8 which is axially movable, and a fixed member 3, in which the movable member 8 is formed at its outer periphery with an external thread 8D which is to be threadedly engaged with an internal thread 19C of a medicine spraying section 19. An air inflow hole H is formed by a perforating end 27A of a pin 27 when a capsule K is thrust into a one-side capsule hole 11, while the movable member 8 is raised so that the perforating end 27A is extracted from the air inflow hole H1 when the capsule holder 2 and the medicine spraying section 19 are incorporated with each other. An air outflow hole H2 is formed by a pin 28. A perforating tool is housed in the medicine administering device 1, in which a hole formation action for the air inflow hole H1 is also made during installation of the capsule K.

Abstract: A nasally administrable composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The composition contains an effective amount of physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a mucosa protecting and/or tissue repairing agent, e.g., gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, cetraxate or troxipide.

Abstract: A capsule holder is provided with a capsule accommodating hole and a supplying valve. A pump section having a sucking valve is provided at the air inflow-side of the capsule holder, while a medicine spraying section having two medicine passages diverging from the capsule accommodating hole and spraying holes is provided at the air outflow-side of the capsule holder. A perforator is housed in the medicine spraying section. A capsule is accommodated in the capsule accommodating hole, and through-holes are formed in the capsule with the perforator, upon which the medicine within the capsule can be administered to the left and right nasal cavities of a patient under the action of air from the pump section. Additionally, a spreading chamber is provided to be formed at the downstream side of the capsule accommodating hole.

Abstract: A distance-adjustable nozzle mechanism 25 is disposed to a passage member 17 to be located at the ejection sides of left and right medicine passages 20, 20. The distance-adjustable nozzle distance 25 includes fitting projection sections 26, 26 formed in the passage member 17, adjustable nozzles 27, 27 which are rotatably and detachably attached to the fitting projection sections 26, and tapered spray holes 28, each of which is in communication with the medicine passage 20 and formed throughout the fitting projection section 26, and the adjustable nozzle 27, in which the axis of the adjustable nozzle 27 is eccentric to a rotational center. Accordingly, when each adjustable nozzle 27 is rotated, the nozzles can approach or separate from each other by an amount corresponding to the eccentricity relative to the rotational center, so that the nozzle pitch between the respective adjustable nozzles 27 can be easily adjusted in conformity with the distance between the nasal cavities of the patient.

Abstract: A medicator for a capsule filled with a powdered drug, comprising: a first member adapted to receive a capsule therein; a second member, having an air supply valve structure, arranged to communicate with the first member and arranged to operatively discharge air sucked from outside the medicator towards the first member in which a capsule is received; an air stream passage formed within the first member and the second member to direct air discharged from the air supply valve structure in a direction towards a capsule received by the first member; a third member removably attached to the first member to spray powdered drug in a capsule out of the medicator with air discharged from the air supply valve structure via the air stream passage; a drug trapping structure formed in the air stream passage to trap part of powdered drug contained in a capsule which falls down into the drug trapping structure; and a drug collecting structure formed in the air stream passage between the drug trapping structure and the air

Abstract: An inhalation type medication delivery device includes a dispenser body having a powder containment chamber at one axial side thereof and an inhalation port for drawing in a powder type medication on the another. An attached lid is provided on the dispenser body for opening and/or closing the powder containment chamber. In addition, an air passage is defined in the body allowing a powder type medication to be introduced into an airflow toward the inhalation port according to inhalation by a user. One end of the air passage opens through the lid towards the outside atmosphere and the other end communicates with the inhalation port while passing through the powder containment chamber. Also, a check valve is installed in the lid to prevent air drawn into said inhalation port from flowing in an outward direction opposite a medication delivery direction toward the inhalation port.

Abstract: An inhaling piece 1 is formed with an inhaling mouth 3 and a holder accommodating section 2. A capsule holder 6 is formed with a capsule accommodating hole 7 and air flow passages 8, 8 which extend axially, and is further formed with pin insertion holes 10, 11 which extend diametrically and are in communication with these air flow passages 8. When a capsule 17 is accommodated in the capsule accommodating hole 7 and the pins 16 are inserted into the pin insertion holes 10, 11, through-holes H, H, . . . are formed in the capsule 17. When the patient intends to inhale medicine, inhaling is made by first returning the pins 16 to the inhaling piece 1 so that the medicine can be securely and effectively carried to the lungs of the patient under the action of air flow.

Abstract: An inhaler type medicine administering device comprises a generally cylindrical inhaling piece including a holder accommodating section located at one side of the inhaling piece, and an inhaling mouth located at the other side of the inhaling piece. A generally cylindrical capsule holder is disposed in the holder accommodating section and formed with a capsule accommodating hole which opens at one end of the capsule holder. A capsule is to be disposed in the capsule accommodating hole. First and second pin insertion holes are formed in the capsule holder and the inhaling piece and respectively located to be connected with axially opposite sections of the capsule accommodating hole. Each pin insertion hole extends generally in a diametrical direction of the inhaling piece and the capsule holder. An air flow passage is axially formed at at least one of an inner peripheral surface of the inhaling piece and an outer peripheral surface of the capsule holder.

Abstract: An inhaler type medicine administering device for administering fine granular medicine to the lungs of a patent. The medicine admimistering device comprises a generally cylindrical inhaling piece including a cylindrical holder accommodating section. First and second outside pin insertion holes are formed through the cylindrical wall of the holder accommodating section. A capsule holder is provided to be accommodable within the holder accommodating section of the inhaling piece. The capsule holder is formed with a capsule accommodating hole opened to its end section in which hole a capsule containing medicine is accommodable. First and second inside pin insertion holes are formed extending in the diametrical direction of the capsule holder so as to pass through the capsule accommodating hole. The first inside pin insertion hole is capable of being brought into alignment with the first outside pin insertion hole to form a first pin insertion hole.

Abstract: A nasally administrable composition having a physiologically active substance dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The nasally administrable composition contains a physiologically effective amount of the physiologically active substance having a molecular weight of not more than 40,000, dispersed homogeneously in and adsorbed homogeneously onto physiologically acceptable powdery or crystalline polyvalence metal compound carrier.The metal compound carrier is selected from aluminum compound, calcium compound, magnesium compound, silicon compound, iron compound and zinc compound.The composition is nasally administrable in powdery form.

Abstract: A physiologically active peptide composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The physiologically active peptide composition contains a physiologically effective amount of the physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto hydroxyapatite. The composition is nasally administrable in powdery form.

Abstract: Disclosed is a novel agent for curing rheumatism, which consists of a pharmaceutical composition containing 5-fluorouracil or an N-derivative thereof to be converted into 5-fluorouracil within the body, which is less in side effects, which has a high degree of safety, and which is high in curing effects.

Abstract: A topical preparation containing cyclosporin as an active ingredient, is disclosed that contains (a) cyclosporin; (b) an organic solvent for dissolving the cyclosporin; (c) an ester of a fatty acid with a monovalent alcohol having a total number of carbon atoms of 8 or more and/or an alkanol amine, each being in liquid state at 25.degree.C; (d) an oily substance in solid state at 25.degree.C; and (e) a surfactant. The cyclosporin is present in a concentration ranging from appoximately 0.1% to 10% by weight and the ester and/or alkanol amine are/is present in a concentration ranging from approximately 1% to 15% by weight. The topical preparations are active against atopic dermatitis, psoriasis and allergic contact dermatitis.

Abstract: Disclosed is a topical preparation for healing wounds of the skin, which can demonstrate remarkable effects of the treatment of wounds of the skin, such as an ulcer of the skin, traumatogenic wounds caused by the abrasion of the skin, traumatogenic wounds caused by the defect of the skin, an ulcer of the crus, zoster, and so on. The topical preparation contains at least one pharmaceutically effective compound selected from gefarnate, and sofalcone.