Abstract: Disclosed are a benzothiazolesulfonamide derivative represented by the formula (I) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein A represents a lower alkylene group which is unsubstituted or substituted; R.sup.1 represents a hydrogen atom or a lower alkyl group; each of R.sup.2 and R.sup.3 independently represents a hydrogen atom or a lower alkyl group, or R.sup.2 and R.sup.3 are bonded together to form a lower alkylene group which is unsubstituted or substituted; and R.sup.4 represents a hydrogen atom, a lower alkyl group, an amidino group, or a phenyl-substituted lower alkyl group, wherein the lower alkyl group is substituted or unsubstituted, and the phenyl group is unsubstituted or substituted with a lower alkyl group, a lower alkoxy group, a halogen atom or a methylenedioxy group;a method for preparing the same; and a pharmaceutical composition comprising the same.

Abstract: Disclosed is a sulfonamide derivative represented by following formula (I) and a medicine for the treatment of asthma comprising the sulfonamide derivative as an active ingredient which exhibits bronchodilation effect. ##STR1## wherein X represents a quinoline residue represented by formula (II) or an isoquinoline residue represented by formula (III) ##STR2## where R.sup.1 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, or ##STR3## where R.sup.2 is a hydrogen atom or a hydroxyl group, and wherein: when X is quinoline residue (II), n is zero or 1, in which,when n is zero, R.sup.4 is an unsubstituted or substituted diazacycloalkyl group, andwhen n is 1, R.sup.3 is a hydrogen atom or a lower alkyl group and R.sup.4 is an unsubstituted or substituted aralkylamino group or an unsubstituted or substituted diazacycloalkyl group; andwhen X is isoquinoline residue (III), n is 1, in which, R.sup.3 is a hydrogen atom or a lower alkyl group and R.sup.

Abstract: Disclosed is a substituted sulfonamide derivative represented by formula (I) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein A represents a hydrogen atom or an alkyl group, G represents a methylene group or an alkylene group, Q.sup.1 represents an ethylene group, Q.sup.2 represents an ethylene group or a trimethylene group, E represents an alkyl group or a group represented by a formula selected from formula (II-a) and (II-b)- G - J - Z (II-a),- G - Z (II-b)wherein G is as defined above, J represents an oxygen atom, a sulfur atom or a nitrogen atom, and Z represents an aryl group unsubstituted or substituted with an alkyl group or an alkoxy group, or a heterocyclic group, andX represents a quinolyl group, an isoquinolyl group, a benzothiazolyl group or a quinazolin-4-on group.